Therapeutic potential of TAM receptors in autoimmune diseases: insights from original studies [0.03%]
TAM受体在自身免疫病治疗中的潜力：原创研究的新见解
Sheu Ibrahim Adedayo,Taiye Abdullahi Gegele,Kehinde Ahmad Adeshina et al.
Sheu Ibrahim Adedayo et al.
TAM receptors, composed of Tyro3, Axl, and Mertk, belong to the receptor tyrosine kinase family and are activated by binding of their cognate ligands, Gas6 and Pros1. These receptor-ligand interactions mediate critical physiological process...
Capturing the full spectrum of T cell responses with spectral flow cytometry [0.03%]
采用光谱流式细胞术捕获T细胞反应的全谱系
Anna Olofsson,Annika C Karlsson
Anna Olofsson
Over a decade has passed since the first commercial spectral flow cytometry (SFC) instrument was introduced. Unlike conventional flow cytometers, SFC utilizes an array of detectors to capture the full emission spectrum of fluorochromes, fro...
Comparative analysis of malignant pleural effusion and peripheral blood reveals unique T cell signatures associated with survival in mesothelioma patients [0.03%]
恶性胸水和外周血的比较分析揭示了间皮瘤患者中与生存相关的独特的T细胞特征
Nicola Principe,Kofi L P Stevens,Amber-Lee Phung et al.
Nicola Principe et al.
The success of cancer immunotherapies has highlighted the importance of monitoring the anti-tumour T cell response. Patients with mesothelioma frequently present with a malignant pleural effusion (MPE) that is commonly drained regularly to ...
Svetlana Blitshteyn
Svetlana Blitshteyn
The SARS-CoV-2 pandemic caused an estimated 400 million people worldwide to experience Long COVID and post-COVID complications leading to significant chronic illness and disability with its devastating physical, societal and economic conseq...
ALIGaToR: a tool for the automated annotation of immunoglobulin and T cell receptor genomic loci [0.03%]
自动注释免疫球蛋白和T细胞受体基因组座位的工具(ALIGaToR)
Chaim A Schramm,Simone Olubo,Daniel C Douek
Chaim A Schramm
Advances in sequencing technology have made it possible to capture complex immunogenetic loci at a scale that exceeds the capacity for manual annotation. Here we present the Annotator of Loci for ImmunoGlobulins and T cell Receptors (ALIGaT...
A user's guide to designing efficient and safe mucosal vaccines: Challenges & potentials [0.03%]
设计高效和安全的黏膜疫苗以应对机遇与挑战——用户指南
Divya Sinha,Prajwal Kargal Gopalakrishna,Stephane Paul et al.
Divya Sinha et al.
Mucosal immunization represents a promising approach to protect against pathogens that enter through mucosal surfaces. This review provides a practical overview of the mucosal immune system's main features and explores the benefits of mucos...
Joan Escrivà-Font,Tianze Cao,Camila Rosat Consiglio
Joan Escrivà-Font
Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more severe infections and increased cancer rates, while women exhibit higher vaccine responses and pr...
PET in the characterization of immune diseases and development of therapeutics [0.03%]
正电子发射断层扫描在免疫性疾病表征及治疗药物开发中的应用
Natasha Patel,Mats Bergstrom,Philip S Murphy et al.
Natasha Patel et al.
The immune system is a complex network of cells, tissues and organs that protects the body against harmful pathogens. Characterization of the immune system is essential for understanding the complex interactions underlying pathophysiology a...
AI in optimized cancer treatment: laying the groundwork for interdisciplinary progress [0.03%]
人工智能在优化癌症治疗中的应用：奠定跨学科进步的基础
Gabriel Kalweit,Evelyn Ullrich,Joschka Boedecker et al.
Gabriel Kalweit et al.
The molecular complexity of cancer presents significant challenges to traditional therapeutic approaches, necessitating the development of innovative treatment strategies capable of addressing the disease's dynamic nature and resistance mec...
Malcolm J W Sim,Beining Li,Eric O Long
Malcolm J W Sim
Class I and II human leukocyte antigens (HLA-I and HLA-II) present peptide antigens for immunosurveillance by T cells. HLA molecules also form ligands for a plethora of innate, germline-encoded receptors. Many of these receptors engage HLA ...