A user's guide to designing efficient and safe mucosal vaccines: Challenges & potentials [0.03%]
设计高效和安全的黏膜疫苗以应对机遇与挑战——用户指南
Divya Sinha,Prajwal Kargal Gopalakrishna,Stephane Paul et al.
Divya Sinha et al.
Mucosal immunization represents a promising approach to protect against pathogens that enter through mucosal surfaces. This review provides a practical overview of the mucosal immune system's main features and explores the benefits of mucos...
Joan Escrivà-Font,Tianze Cao,Camila Rosat Consiglio
Joan Escrivà-Font
Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more severe infections and increased cancer rates, while women exhibit higher vaccine responses and pr...
PET in the characterization of immune diseases and development of therapeutics [0.03%]
正电子发射断层扫描在免疫性疾病表征及治疗药物开发中的应用
Natasha Patel,Mats Bergstrom,Philip S Murphy et al.
Natasha Patel et al.
The immune system is a complex network of cells, tissues and organs that protects the body against harmful pathogens. Characterization of the immune system is essential for understanding the complex interactions underlying pathophysiology a...
AI in optimized cancer treatment: laying the groundwork for interdisciplinary progress [0.03%]
人工智能在优化癌症治疗中的应用：奠定跨学科进步的基础
Gabriel Kalweit,Evelyn Ullrich,Joschka Boedecker et al.
Gabriel Kalweit et al.
The molecular complexity of cancer presents significant challenges to traditional therapeutic approaches, necessitating the development of innovative treatment strategies capable of addressing the disease's dynamic nature and resistance mec...
Malcolm J W Sim,Beining Li,Eric O Long
Malcolm J W Sim
Class I and II human leukocyte antigens (HLA-I and HLA-II) present peptide antigens for immunosurveillance by T cells. HLA molecules also form ligands for a plethora of innate, germline-encoded receptors. Many of these receptors engage HLA ...
Mucosal-associated invariant T (MAIT) cell responses in Salmonella enterica serovar Typhi strain Ty21a oral vaccine recipients [0.03%]
口服伤寒疫苗Ty21a株受种者的黏膜相关不变T细胞(MAIT细胞)应答反应
Shubhanshi Trivedi,Olivia J Cheng,Ben J Brintz et al.
Shubhanshi Trivedi et al.
Mucosal-associated invariant T (MAIT) cells are unconventional innate-like T cells abundant in human mucosal tissues and are associated with protective responses to microbial infections. MAIT cells have the capacity for rapid effector funct...
Linoy Menda Dabran,Alona Zilberberg,Sol Efroni
Linoy Menda Dabran
The purpose of this study is to evaluate the feasibility of using RNA sequencing data as substrate for the computational extraction of T cell receptor sequences. Data from hundreds of thousands of samples is available as RNA sequencing. How...
Impact of cryopreservation on immune cell metabolism as measured by SCENITH [0.03%]
基于SCENITH评估的免疫细胞冻存对免疫细胞代谢的影响研究
Curtis Luscombe,Eben Jones,Michaela Gregorova et al.
Curtis Luscombe et al.
The dynamic functioning of immune cells is regulated by cellular metabolic processes, and there is growing interest in the study of immunometabolic correlates of dysfunctional immune responses. SCENITH is a novel flow cytometry-based techni...
In-depth characterization of T cell responses with a combined Activation-Induced Marker (AIM) and Intracellular Cytokine Staining (ICS) assay [0.03%]
结合活化诱导标记物（AIM）和细胞内细胞因子染色（ICS）测定的T细胞反应深入表征
Yeji Lee,Alison Tarke,Alba Grifoni
Yeji Lee
Since T cells are key mediators in the adaptive immune system, evaluating antigen-specific T cell immune responses is pivotal to understanding immune function. Commonly used methods for measuring T cell responses include Activation-Induced ...
CRISPR CLIP: comprehensive reviews on interventional studies using precision recombinant technologies: clinical landmarks, implications, and prospects [0.03%]
基于精准重组技术的干预性研究综合述评：临床里程碑、启示及前景
Swarali Yatin Chodnekar,Zurab Tsetskhladze
Swarali Yatin Chodnekar
To consolidate clinical trials that utilized the CRISPR technology to synthesise cures for various genetic diseases as a means to provide a window into the progress made so far while paving the way forward for future research and practices....