Mucosal-associated invariant T (MAIT) cell responses in Salmonella enterica serovar Typhi strain Ty21a oral vaccine recipients [0.03%]
口服伤寒疫苗Ty21a株受种者的黏膜相关不变T细胞(MAIT细胞)应答反应
Shubhanshi Trivedi,Olivia J Cheng,Ben J Brintz et al.
Shubhanshi Trivedi et al.
Mucosal-associated invariant T (MAIT) cells are unconventional innate-like T cells abundant in human mucosal tissues and are associated with protective responses to microbial infections. MAIT cells have the capacity for rapid effector funct...
Linoy Menda Dabran,Alona Zilberberg,Sol Efroni
Linoy Menda Dabran
The purpose of this study is to evaluate the feasibility of using RNA sequencing data as substrate for the computational extraction of T cell receptor sequences. Data from hundreds of thousands of samples is available as RNA sequencing. How...
Impact of cryopreservation on immune cell metabolism as measured by SCENITH [0.03%]
基于SCENITH评估的免疫细胞冻存对免疫细胞代谢的影响研究
Curtis Luscombe,Eben Jones,Michaela Gregorova et al.
Curtis Luscombe et al.
The dynamic functioning of immune cells is regulated by cellular metabolic processes, and there is growing interest in the study of immunometabolic correlates of dysfunctional immune responses. SCENITH is a novel flow cytometry-based techni...
In-depth characterization of T cell responses with a combined Activation-Induced Marker (AIM) and Intracellular Cytokine Staining (ICS) assay [0.03%]
结合活化诱导标记物（AIM）和细胞内细胞因子染色（ICS）测定的T细胞反应深入表征
Yeji Lee,Alison Tarke,Alba Grifoni
Yeji Lee
Since T cells are key mediators in the adaptive immune system, evaluating antigen-specific T cell immune responses is pivotal to understanding immune function. Commonly used methods for measuring T cell responses include Activation-Induced ...
CRISPR CLIP: comprehensive reviews on interventional studies using precision recombinant technologies: clinical landmarks, implications, and prospects [0.03%]
基于精准重组技术的干预性研究综合述评：临床里程碑、启示及前景
Swarali Yatin Chodnekar,Zurab Tsetskhladze
Swarali Yatin Chodnekar
To consolidate clinical trials that utilized the CRISPR technology to synthesise cures for various genetic diseases as a means to provide a window into the progress made so far while paving the way forward for future research and practices....
The current understanding of the phenotypic and functional properties of human regulatory B cells (Bregs) [0.03%]
人调节性B细胞（Bregs）的表型和功能属性的当前认识
Nawara Faiza Ahsan,Stella Lourenço,Dimitra Psyllou et al.
Nawara Faiza Ahsan et al.
B cells can have a wide range of pro- and anti- inflammatory functions. A subset of B cells called regulatory B cells (Bregs) can potently suppress immune responses. Bregs have been shown to maintain immune homeostasis and modulate inflamma...
Climate change impacts on dengue transmission areas in Espírito Santo state, Brazil [0.03%]
巴西埃斯皮里图桑特州气候改变对登革热传播区域的影响
Yasmim Barcellos Madeira Rosa,Henrique Tamanini Silva Moschen,Ana Carolina Loss et al.
Yasmim Barcellos Madeira Rosa et al.
Espírito Santo state, in Brazil, is a dengue-endemic region predicted to suffer from an increase in temperature and drought due to climate change, which could affect the areas with active dengue virus transmission. The study objective was ...
Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology [0.03%]
阴道念珠菌病中的炎症细胞因子信号：驱动免疫病理的复杂问题
Kar On Cheng,Dolly E Montaño,Teresa Zelante et al.
Kar On Cheng et al.
Protective immunity to opportunistic fungal infections consists of tightly regulated innate and adaptive immune responses that clear the infection. Immune responses to infections of the vaginal mucosa by Candida species are, however, an exc...
The airway mycobiome and interactions with immunity in health and chronic lung disease [0.03%]
呼吸道真菌组及其与健康和慢性肺病状态下免疫的相互作用
Orestis Katsoulis,Oliver R Pitts,Aran Singanayagam
Orestis Katsoulis
The existence of commensal fungi that reside within the respiratory tract, termed the airway mycobiome, has only recently been discovered. Studies are beginning to characterize the spectrum of fungi that inhabit the human upper and lower re...
Early interferon lambda production is induced by double-stranded RNA in iPS-derived hepatocyte-like cells [0.03%]
由诱导性多功能干细胞来源的肝细胞样细胞通过双链RNA诱导早期产生干扰素λ
Vasile Mihai Sularea,Ruchi Sharma,David C Hay et al.
Vasile Mihai Sularea et al.
Hepatotropic viruses are amongst the most ubiquitous pathogens worldwide, causing significant morbidity and mortality. As hepatocytes are among the primary targets of these viruses, their ability to mount early effective innate defence resp...