The opposite effects of stringent response on phage infection of Pseudomonas putida [0.03%]
严格应答对假单胞菌感染的相反效应
Alicja Cecylia Lewańczyk,Mariliis Hinnu,Elise Mägi et al.
Alicja Cecylia Lewańczyk et al.
Guanosine tetra- and pentaphosphate ((p)ppGpp) are one of the key players in the stress response of bacteria. Accumulation of these alarmones activates the stringent response, usually triggered by different nutritional stresses. For Pseudom...
The complexity of multiple CRISPR arrays in strains with (co-occurring) CRISPR systems [0.03%]
含有(共存)CRISPR系统的菌株中多个CRISPR阵列的复杂性
Axel Fehrenbach,Alexander Mitrofanov,Rolf Backofen et al.
Axel Fehrenbach et al.
CRISPR and their associated Cas proteins provide adaptive immunity in prokaryotes, protecting against invading genetic elements. These systems are categorized into types and are highly diverse. Genomes often harbor multiple CRISPR arrays va...
CoMPaseD: advanced planning of proteomic experiments aiming to identify small proteins [0.03%]
基于小蛋白质鉴定的蛋白质组实验先进规划方法(CoMPaseD)
Jürgen Bartel,Philipp T Kaulich,Borja Ferrero-Bordera et al.
Jürgen Bartel et al.
In proteome studies, the application of alternative proteases, exclusively or in addition to trypsin, often increases protein sequence or proteome coverage. It has recently been shown that, in particular, the analysis of small proteins bene...
A subset of type 4 secretion system effectors of Brucella spp. associates to outer membrane vesicles [0.03%]
布鲁氏菌属四型分泌系统效应物的子集与外膜囊泡相关联
Maren Ketterer,Naadir Ganief,Petra Chiquet et al.
Maren Ketterer et al.
The establishment of a replicative niche in the hostile environment of the host presents an enormous challenge for pathogens. Intracellular pathogens such as Brucella spp., the Gram-negative causative agents of Brucellosis, must subvert div...
Obligate heterotrophy of hyperthermophilic archaea Pyrobaculum arsenaticum and P. aerophilum [0.03%]
超嗜热性古菌Pyrobaculum arsenaticum和P.aerophilum的专性异养性
Eugenio Pettinato,Thomas M Steiner,Christian Seitz et al.
Eugenio Pettinato et al.
Pyrobaculum arsenaticum and P. aerophilum are two hyperthermophiles that belong to the phylum Thermoproteota (also known as Crenarchaeota), order Thermoproteales. Pyrobaculum arsenaticum is an obligate anaerobe, whereas P. aerophilum is a f...
Fernando Baquero,Roberto Kolter,Kenneth Timmis
Fernando Baquero
Editorial
microLife. 2025 Dec 26:7:uqaf044. DOI:10.1093/femsml/uqaf044 2025
Exploring Bacteroidota strains from human stool and animal feces: phenotyping and functional diversity [0.03%]
人粪便和动物粪便中拟杆菌门菌株的分离鉴定及功能多样性分析
Lisa Ladewig,Birhanu M Kinfu,Hanna Fokt et al.
Lisa Ladewig et al.
Bacteroidota, a diverse phylum of bacteria, includes classes whose members are increasingly recognized for their significant contributions to host health, particularly through their antimicrobial properties. This study investigates the func...
Glucose metabolism controls oxidative burst and lipid mediator production in neutrophils upon microbial challenge [0.03%]
糖代谢调控中性粒细胞的氧化爆发和微生物刺激下的脂质介质生成
Alexandra Freitag,Kerstin Günther,Miriam Campillo Prados et al.
Alexandra Freitag et al.
Neutrophils are frontline responders against bacterial and fungal pathogens, requiring rapid energy and biosynthetic precursors to mount effective antimicrobial responses. To meet these demands, they primarily rely on aerobic glycolysis, ma...
Guided tour through the small protein landscape of Methanosarcina mazei using proteomics and biochemical approaches [0.03%]
基于蛋白质组及生化方法对Methanosarcina mazei小型蛋白进行分析研究
Eva Herdering,Liam Cassidy,Philipp T Kaulich et al.
Eva Herdering et al.
Small open reading frame (small ORF) encoded proteins fulfil important roles in many cellular processes. In the methanoarchaeon Methanosarcina mazei, numerous small proteins have previously been identified under different nitrogen-availabil...
Impact of changed c-di-AMP levels and hypoosmotic stress on the transcriptome of Haloferax volcanii and on RCK domain-containing proteins [0.03%]
Haloferax火山硫化叶菌中c-di-AMP水平变化和低渗压力对其转录组的影响及对含RCK结构域蛋白的影响
Hongcheng Ren,Frank Braun,Felix Grünberger et al.
Hongcheng Ren et al.
We investigated the role of cyclic di-adenosine monophosphate (c-di-AMP) in the halophilic archaeon Haloferax volcanii by analysing transcriptomic changes in a strain with lowered c-di-AMP levels and by characterizing the function of key RC...