Kristina Driller,Fabián A Cornejo,Kürşad Turgay
Kristina Driller
The alarmones and second messengers (p)ppGpp are important for the cellular response to amino acid starvation. Although the stringent response is present in many bacteria, the targets and functions of (p)ppGpp can differ between species, an...
The role of peptidoglycan hydrolases in the formation and toxicity of Pseudomonas aeruginosa membrane vesicles [0.03%]
肽聚糖水解酶在铜绿假单胞菌膜囊泡形成及毒性中的作用研究
Yi-Chi Chen,Ratchara Kalawong,Masanori Toyofuku et al.
Yi-Chi Chen et al.
Bacterial membrane vesicles (MVs) have been reported to kill other bacteria. In the case of Pseudomonas aeruginosa the bactericidal activity has been attributed to an unidentified 26 kDa peptidoglycan (PG) hydrolase that is associated with ...
Sarah Wettstadt
Sarah Wettstadt
About the scientific life of Philippe Sansonetti. © The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.
Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor [0.03%]
计算辅助设计环二磷酸腺苷合成酶CdaA的抑制剂
Piotr Neumann,Patrick Kloskowski,Ralf Ficner
Piotr Neumann
Cyclic di-AMP (c-di-AMP) is an essential secondary messenger regulating cell wall homeostasis and myriads of physiological processes in several Gram-positive and mycobacteria, including human pathogens. Hence, c-di-AMP synthesizing enzymes ...
Sarah Wettstadt
Sarah Wettstadt
Editorial
microLife. 2023 Jan 4:4:uqac024. DOI:10.1093/femsml/uqac024 2023
Revealing the small proteome of Haloferax volcanii by combining ribosome profiling and small-protein optimized mass spectrometry [0.03%]
结合核糖体谱型和小蛋白优化质谱技术揭示Haloferax volcanii的小蛋白质组
Lydia Hadjeras,Jürgen Bartel,Lisa-Katharina Maier et al.
Lydia Hadjeras et al.
In contrast to extensively studied prokaryotic 'small' transcriptomes (encompassing all small noncoding RNAs), small proteomes (here defined as including proteins ≤70 aa) are only now entering the limelight. The absence of a complete small...
Cyclic di-AMP, a multifaceted regulator of central metabolism and osmolyte homeostasis in Listeria monocytogenes [0.03%]
环二腺苷酸在单核细胞增生性李斯特菌的碳源代谢和渗透压稳态中发挥多功能调控作用
Inge Schwedt,Mengyi Wang,Johannes Gibhardt et al.
Inge Schwedt et al.
Cyclic di-AMP is an emerging second messenger that is synthesized by many archaea and bacteria, including the Gram-positive pathogenic bacterium Listeria monocytogenes. Listeria monocytogenes played a crucial role in elucidating the essenti...
Pathogen vacuole membrane contact sites - close encounters of the fifth kind [0.03%]
病原体胞内泡膜接触位点——第五种膜接触位点
Simone Vormittag,Rachel J Ende,Isabelle Derré et al.
Simone Vormittag et al.
Vesicular trafficking and membrane fusion are well-characterized, versatile, and sophisticated means of 'long range' intracellular protein and lipid delivery. Membrane contact sites (MCS) have been studied in far less detail, but are crucia...
Analysis of a logical regulatory network reveals how Fe-S cluster biogenesis is controlled in the face of stress [0.03%]
一种逻辑调控网络的分析揭示了应激条件下如何控制铁硫簇生物合成
Firas Hammami,Laurent Tichit,Béatrice Py et al.
Firas Hammami et al.
Iron-sulfur (Fe-S) clusters are important cofactors conserved in all domains of life, yet their synthesis and stability are compromised in stressful conditions such as iron deprivation or oxidative stress. Two conserved machineries, Isc and...
Microbiology education: a significant path to sustainably improve the human and biosphere condition [0.03%]
微生物教育：提高人类和生物圈状况的重要途径
Kenneth Timmis
Kenneth Timmis
In this short piece, I connect the dots between the pervasive influence of microbial activities on our health and that of the planet, including their positive and negative roles in current polycrises, our ability to influence microbes to pr...