Enhanced Antimalarial Efficacy of Annona muricata Leaf Extract Combined With Artesunate, Chloroquine, and Pyrimethamine in Plasmodium berghei-Infected ICR Mice [0.03%]
Annona muricata叶提取物联合青蒿素、氯喹和甲氟喹增强ICR小鼠 Plasmodium berghei感染的抗疟药疗效
Orawan Sarakul,Rachasak Boonhok,Voravuth Somsak
Orawan Sarakul
Malaria continues to be a significant global health challenge, particularly in tropical and subtropical regions, due to its high morbidity and mortality rates. The development of resistance to conventional antimalarial drugs underscores the...
Combining Plant Bioactives With Antibiotics for Enhanced Antibiofilm Activity Against Uropathogenic Staphylococcus spp. and Cytotoxicity Evaluation [0.03%]
植物生物活性物质联合抗生素增强对抗尿路致病性葡萄球菌生物被膜活性及细胞毒性评价
Ulrich Joël Tsopmene,Christian Ramsès Kuate Tokam,Larissa Yetendje Chimi et al.
Ulrich Joël Tsopmene et al.
Urinary tract infections (UTIs) are one of the most important causes of morbidity and healthcare spending. Combination therapy is the treatment of choice for biofilm-associated infections due to the simultaneous action of two drugs on two s...
Real-World Evaluation of the Interaction Between Rifampicin and Warfarin: A Retrospective Observational Study [0.03%]
利福平与华法林相互作用的现实世界评价：回顾性观察研究
Lina Naseralallah,Dima Nasrallah,Somaya Koraysh et al.
Lina Naseralallah et al.
Background: Drug-drug interactions (DDIs) pose a significant challenge in drug therapy, particularly due to concerns about the safety and effectiveness of combined medications. Rifampicin is a strong inducer of the enzyme CYP2C9, which like...
Safety, Tolerability, and Pharmacokinetics of NorUrsodeoxycholic Acid (Shilpa Medicare Limited, India) in Healthy Adults: Results From a Phase I Open-Label Dose-Escalation Study [0.03%]
舒派德（印度希帕有限公司）在健康受试者中的安全性和耐受性及药代动力学I期开放标记递增剂量试验结果
Veerendra Kumar Panuganti,Chandrasekhar Varma Alluri,Mamatha Reddy Dundigalla et al.
Veerendra Kumar Panuganti et al.
NorUrsodeoxycholic acid (norUDCA) is a side-chain-shortened derivative of ursodeoxycholic acid (UDCA) with specific pharmacological properties, including cholehepatic shunting, making it a promising candidate for a range of cholestatic and ...
In Vitro Cytotoxic and Molecular Docking Studies of the Network Pharmacology Approach From Bioactive Compounds of Coleus amboinicus Leaves Against Lung and Breast Cancer Cells [0.03%]
基于网络药理学的青蒿叶活性成分抗肺癌和乳腺癌的体外细胞毒性及分子对接研究
Kasta Gurning,Gian Primahana,Endang Astuti et al.
Kasta Gurning et al.
Lung cancer and breast cancer are two types of cancer that cause and contribute to the highest mortality rate in the world. The development of anticancer agents that have high efficacy and relatively low side effects continues to be develop...
Innovative Multilayered Electrospun Fiber Systems for Dual-Action HIV Prophylaxis and Nonhormonal Contraception [0.03%]
用于预防艾滋病毒和非激素避孕的创新型多层静电纺丝纤维系统
Deborah A Ogundemuren,Peace-Ofonabasi O Bassey,Karamot O Oyediran et al.
Deborah A Ogundemuren et al.
Background: Electrospun fiber drug delivery systems, integrated into multipurpose prevention technologies, offer a promising solution for women facing health risks from HIV/STIs and unmet contraceptive needs by providing on-demand protectio...
Smartphone-Assisted Thin-Layer Chromatography for Rapid Quality Screening of Metformin [0.03%]
基于智能手机辅助薄层色谱的快速筛查甲福明质量的方法研究
Ram Kumar Bhattarai,Sanam Pudasaini,Toni Barstis et al.
Ram Kumar Bhattarai et al.
Type II diabetes remains a significant global public health issue, affecting both individual well-being and healthcare systems worldwide. Metformin hydrochloride is widely prescribed as the first-line treatment for managing diabetes. Howeve...
Evaluation of Methods Employed in Establishing Preclinical Similarity of Adalimumab Biosimilars [0.03%]
评估阿达木单抗仿制药生物相似性的非临床方法学分析
Ramya Nair,Naveen Krishnan,Vasudev Shenoy et al.
Ramya Nair et al.
Adalimumab, marketed as Humira, is a fully humanized monoclonal antibody that blocks the activity of tumor necrosis factor-alpha and is used in treating several autoimmune disorders. As one of the top-grossing pharmaceuticals, its global sa...
Determinants of Benzodiazepine-Dispensing Practice Among Community Pharmacy Dispensers in Dar es Salaam, Tanzania [0.03%]
坦桑尼亚达累斯萨拉姆社区药房调配苯二氮卓类药物的决定因素
Adhra R Mansour,Joseph Matobo Thobias,Emili Yondu et al.
Adhra R Mansour et al.
Purpose: This cross-sectional study assessed determinants of benzodiazepine (BZP)-dispensing practices among community pharmacy dispensers in Dar es Salaam, Tanzania. Methods: A cross-sectional study involving 378 community pharmacy dispens...
Tacca chantrieri André Rhizome Extract Alleviates Scopolamine-Induced Cognitive Impairment and Neuroinflammation in Rats [0.03%]
安德铁兰素薯蓣提取物对印防己碱致大鼠认知障碍和神经炎症的改善作用
Thaneeya Hawiset,Napatr Sriraksa,Shisanupong Anukanon et al.
Thaneeya Hawiset et al.
Tacca chantrieri André is a native plant from Northern Thailand with reported pharmacological effects, including antioxidant, anti-inflammatory, and neuroprotective properties. This study investigated the neuroinflammatory and cognitive-en...