Bazedoxifene and Beyond: Identifying This SERM's Targets and Deciphering Its Molecular Mechanisms [0.03%]
拜泽odoxif烯及其作用靶点和分子机制研究展望
Juliette Bherer,Alisson Clemenceau,Caroline Diorio et al.
Juliette Bherer et al.
Bazedoxifene (BZA), a third-generation selective estrogen receptor modulator (SERM) approved for osteoporosis treatment, is attracting attention for drug repurposing, especially in cancer research. While designed primarily for estrogen rece...
Ibuprofen and Palmitic Acid-Based Solvent Exchange-Induced In Situ Forming Matrices With Gentian Violet for Oropharyngeal Candidiasis and Periodontitis Treatment [0.03%]
用于口咽念珠菌病和牙周炎治疗的对乙酰氨基酚和棕榈酸基溶剂交换原位形成矩阵中的龙胆紫
Thawatchai Phaechamud,Panadda Phattanawasin,Setthapong Senarat et al.
Thawatchai Phaechamud et al.
Background: Gentian violet (GV) is a broad-spectrum antimicrobial agent with documented efficacy against oropharyngeal candidiasis and periodontal pathogens, but its clinical use is limited by poor local retention. In sit...
Protective Role of Linagliptin in Cisplatin-Mediated Liver Injury: Involvement of STAT3 and AMPK/SIRT1/PGC-1alpha Mitochondrial Energy Sensing Networks [0.03%]
利那利替丁在顺铂介导的肝损伤中的保护作用：STAT3和AMPK/SIRT1/PGC-1α线粒体能量感应网络的参与作用
Marawan A Elbaset,Bassim M S A Mohamed,Passant E Moustafa et al.
Marawan A Elbaset et al.
Cisplatin (Cis), a commonly used chemotherapy drug, is associated with liver toxicity, which restricts its broader clinical use. This study investigated the potential protective effects of linagliptin (Lina), a DPP-4 inhibitor, in preventin...
Fingerroot Extract Oral Spray for Anticariogenic Purpose: Integration of Ultrasound-Assisted Extraction and Solvent System Optimization [0.03%]
超声波辅助提取和溶剂系统优化结合的指根提取物口腔喷雾的防龋用途研究
Chaowalit Monton,Thaniya Wunnakup,Jirapornchai Suksaeree et al.
Chaowalit Monton et al.
Fingerroot (Boesenbergia rotunda (L.) Mansf.), a member of the Zingiberaceae family, exhibits anticariogenic activity against Streptococcus mutans. This study aimed to optimize ultrasound-assisted extraction and solvent system selection for...
Long-Term Risk of Type 2 Diabetes Associated With Topical Corticosteroid Use: A Nationwide Population-Based Cohort Study in Korea [0.03%]
韩国全国人群为基础的队列研究中关于外用皮质类固醇与2型糖尿病长期发病风险关联的研究
Seungwoo Kim,Ji Hui An,In Sun Ryou et al.
Seungwoo Kim et al.
Steroid-induced diabetes mellitus (SIDM) is a well-known side effect of corticosteroid agents. While diabetes induced by systemic corticosteroids has been extensively studied for over 60 years, evidence regarding the association between top...
Nrf2/GPX4-Dependent Ferroptosis Inhibition: The Central Mechanism Underpinning Germacrone-Induced Cardioprotection in Myocardial Infarction [0.03%]
球黏药素诱导的心肌梗死心脏保护作用依赖于Nrf2/GPX4介导的铁死亡抑制机制
Jiaxiang Liao,Zitian Wang,Zhou Huang et al.
Jiaxiang Liao et al.
Myocardial infarction (MI) involves a pathological process in which its association with ferroptosis is notably pronounced, and targeted regulation of ferroptosis presents a promising approach for treating MI. This work delineates the molec...
Effects of Sesamum indicum L. Seed Extract on Male Reproductive Parameters and In Silico Anti-Infertility Insights [0.03%]
补骨脂种子提取物对雄性生殖参数的影响及计算机辅助的抗不孕新见解
John I Ogbu,Efe Omorodion-Osagie,Funmileyi O Awobajo et al.
John I Ogbu et al.
The etiological contribution of male factors to infertility remains a significant concern in reproductive health. Natural dietary products are gaining attention as promising interventions to improve male infertility. This study investigates...
Mechanistic Insights Into House Dust Mites Immunotherapy-Induced Desensitization for Sustained Protection of Allergic Rhinitis in Mice [0.03%]
小鼠尘螨免疫疗法致敏以维持对过敏性鼻炎的耐受的机制见解
Ahmad Dzulfikri Nurhan,Yu-Wen Cheng,George Hsiao et al.
Ahmad Dzulfikri Nurhan et al.
The worldwide prevalence of allergic rhinitis (AR) is substantial and is considered a global health problem. Allergen immunotherapy (AIT) is the only approach that treats the underlying cause of allergy by inducing a desensitization respons...
Exploring the Anti-Nociceptive, Anti-Inflammatory, Anti-Pyretic, and Anti-Arthritic Activity of Methanolic Extract of Desmos chinensis and Its Different Solvent Fractions: In Vivo, In Vitro, and In Silico Intervention [0.03%]
Desmos chinensis甲醇提取物及其不同溶剂部分分的抗痛，抗炎，解热和抗关节活性：体内，体外和分子对接研究
Nigar Sultana Prithy,Ainun Nahar,Md Jahirul Islam Mamun et al.
Nigar Sultana Prithy et al.
Objective: Desmos chinensis (Annonaceae) is an underexplored medicinal plant from Southeast Asia with limited pharmacological validation. This study investigated, for the first time, the analgesic, anti-pyretic, anti-infl...
Study of Ex Vivo and In Vivo Effect of Topical Ionic Solution of Diclofenac Sodium in Male Albino Rats Using Iontophoretic Technique [0.03%]
离子导入技术下外用钠通道阻滞剂在大鼠体内体外镇痛效果的研究
Hasnan Ali,Sadia Ahmed Zuberi,Noreen Tariq
Hasnan Ali
Background: This study is designed to overcome the limitations of transdermal drug delivery by developing a customized iontophoretic device to rapidly increase the delivery of NSAIDs (diclofenac sodium [DS]). ...