A Comparative pH-Dissolution Profile Analysis of Selected Commercial Levothyroxine Formulations in Lebanon Using Anion-Exchange HPLC Method: Implication on Interchangeability [0.03%]
高效液相色谱法测定黎巴嫩几种左旋甲状腺素制剂的pH溶出度差异及由此引起的替代风险评估
Malak AlBathish,Azza Gazy,Marwa Al Jamal
Malak AlBathish
Hypothyroidism is a common endocrine disorder that requires medical intervention by the administration of hormone replacement therapy: levothyroxine-a drug recognized as a NTI drug. Generic levothyroxine formulations can be considered as an...
Intranasal Administration of Disulfiram in Rats Produces Rapid and Potent Anxiolytic-Like Effects Without Adverse Alcohol-Related Interactions [0.03%]
氯化二硫醒的鼻内给药可快速有效地产生抗焦虑作用且不增加酒精中毒的风险
Arisa Ohta,Yuya Terashima,Kota Matsuura et al.
Arisa Ohta et al.
Background: The U.S. Food and Drug Administration has approved disulfiram (DSF) as a treatment for alcoholism. DSF shows strong anxiolytic-like effects in mice without the side effects commonly associated with benzodiazepines. However, when...
Regulation of Cerebral BDNF, VEGF, and GluN2B Gene Expression and Cytokine Levels by Riparin A in a Murine Model of Depression [0.03%]
雷公藤红素A通过调控抑郁模型小鼠海马BDNF、VEGF和GluN2B基因表达及细胞因子水平的作用机制研究
Raphaela Gonçalves Barros,Julia Nunes Estrela de Carvalho,Cássio Prinholato da Silva et al.
Raphaela Gonçalves Barros et al.
Riparin A is a synthetic compound with established antidepressant and anxiolytic properties. Given its therapeutic potential and the crucial roles of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and t...
Antioxidant Potential of Mangifera foetida Bark, Mangifera foetida Leaves, and Cinnamomum burmanii Leaves Extract in Mitigating Nanoplastic-Induced Toxicity and Disruption of Glycolipid Metabolism [0.03%]
mango树皮、芒果叶和 Indonesian玉桂叶提取物的抗氧化潜力可缓解纳米塑料引起的毒性及糖脂代谢紊乱
Manikya Pramudya,Raden Joko Kuncoroningrat Susilo,Windy Seftiarini et al.
Manikya Pramudya et al.
Pollution from plastic waste has become an urgent issue, requiring solutions to prevent and mitigate diseases caused by plastic waste, particularly those involving nanoplastics (NP). This study specifically focused on investigating the exog...
Cecropia angustifolia Pentacyclic Triterpene Acids and Sacha Inchi Oil Improve Carbohydrate Metabolism and Inflammation in Prediabetic Mice [0.03%]
三环酸和 Sacha Inchi油改善糖尿病小鼠的糖代谢和炎症反应
Johanna Valentina Lopez-Cortes,Sergio Acin-Martinez,Guillermo Montoya et al.
Johanna Valentina Lopez-Cortes et al.
Type 2 diabetes mellitus is closely linked with obesity and associated metabolic dysfunctions, including insulin resistance, dyslipidemia, and chronic inflammation. Pentacyclic triterpene acids (PTAs) derived from Cecropia angustifolia are ...
Essential Oil From Dittrichia viscosa L.: A Potential Source of Bioactive Substances With Antioxidant, Antimicrobial, and Antidiabetic Properties: In Vitro and In Silico Studies [0.03%]
Dittrichia viscosa L.的精油：一种具有抗氧化、抗菌和抗糖尿病活性物质的潜在来源：体外和分子对接研究
Nesrine Benkhaira,Mohamed El Fadili,Naoufal El Hachlafi et al.
Nesrine Benkhaira et al.
In Morocco, Dittrichia viscosa L. has long been used to treat a variety of illnesses. The objective of this work was to comprehensively evaluate the essential oil (EO) derived from D. viscosa essential oil (DVEO) for its antibacterial, anti...
Enhanced Solubility and Rapid Delivery of Vitamin D3 via Captisol® (β-Cyclodextrin Sulfobutyl Ether) Inclusion Complex in Mouth-Dissolving Films [0.03%]
通过Captisol(2-羟丙基-β-环糊精硫酸钠酯)包合物使维生素D3在口崩膜中溶出度提高及快速传递
Sultana Essa Bin Haider,Sharav Desai,Aliasgar F Shahiwala
Sultana Essa Bin Haider
Purpose: Vitamin D3 deficiency is a global health concern affecting millions. However, its lipophilicity and poor water solubility limit its pharmaceutical applications. This study aims to improve the solubility of vitamin D3 by forming an ...
Alpha-Mangostin Alleviates Mitochondrial Damage and Autophagy Dysregulation in the MPP+ Cellular Model of Parkinson's Disease [0.03%]
Garcinia属植物茋类成分α- Mangostin改善1-甲基-4-苯基吡啶离子诱导的细胞模型帕金森病线粒体损伤和自噬异常的作用研究
Korede Jacob Abraham,Permphan Dharmasaroja
Korede Jacob Abraham
Alpha-mangostin (α-M), a xanthone derivative with known antioxidative properties, has demonstrated a protective effect on neurons under oxidative stress, a key factor in the pathogenesis of Parkinson's disease (PD). However, its impact on ...
Encapsulation of Curcumin and Gemcitabine: Cytotoxic Effect and Mechanisms of Death in Lung Cancer [0.03%]
姜黄素和吉西他滨的包封：肺癌细胞毒效应及其死亡机制
Oscar Alberto Alvarez-Quezada,Norma Cesilia Arellano-Rodríguez,Mara Valeria Rodríguez-Rodríguez et al.
Oscar Alberto Alvarez-Quezada et al.
Lung cancer is the second most common type of cancer and the leading cause of cancer-related deaths worldwide. Some chemotherapeutic agents, such as curcumin and gemcitabine, have low bioavailability due to their hydrophobicity or the need ...
In Vitro Investigation of the Cytotoxic and Antioxidant Activities of Ardisia polycephala, Iresine herbstii, and Oenanthe javanica Extracts With Potential Applications in Breast Cancer Therapy [0.03%]
体外细胞毒性和抗氧化活性的研究：三种具有潜在乳腺癌治疗应用价值的植物提取物
Nuntika Prommee,Ubonwan Saesiw,Thana Juckmeta et al.
Nuntika Prommee et al.
Ardisia polycephala, Iresine herbstii, and Oenanthe javanica are commonly used to nourish women's blood and treat reproductive system diseases, according to Thai Traditional Medicine (TTM) scriptures. This study explores the biological acti...