Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases [0.03%]
复杂炎症性疾病中纤维蛋白样微凝块复合物的隐藏生物学机制探究
Justine Grixti,Etheresia Pretorius,Douglas B Kell
Justine Grixti
Blood can clot into anomalous, fibrinolysis-resistant forms that arise from prothrombotic seeding areas, including damaged cellular debris and membrane-derived surfaces, giving rise to what we have termed fibrinaloid microclot complexes (co...
Recent advances of in situ and in vivo electrochemical analysis of brain chemistry at micro- and nanoscale [0.03%]
微纳米尺度下脑化学的原位和在体电化学分析最新研究进展
Jinger Chen,Lijiao Cao,Yuying Liu et al.
Jinger Chen et al.
Real-time, in situ monitoring of neurochemical dynamics in intact neural circuits is critical for elucidating brain function. Recent innovations in micro- and nanoelectrode engineering have markedly advanced our ability to detect neurotrans...
Harry Gray,Jay Winkler
Harry Gray
The cytochrome P450 enzymes catalyze the hydroxylation of organic substrates by dioxygen. The high-potential reactive intermediate in cytochrome P450 catalysis, compound I (CI), has the capacity to deliver oxidizing equivalents (holes) to t...
Carol V Robinson,Emma Lalande
Carol V Robinson
Editorial
QRB discovery. 2026 May 6:7:e6. DOI:10.1017/qrd.2026.10020 2026
Electrochemical measurements at human iPSC-derived FOXA2 dopaminergic neurons suggest a role for partial release in presynaptic plasticity [0.03%]
在由人多能干细胞衍生的FOXA2多巴胺能神经元中进行的电化学测量表明，部分释放参与突触前可塑性
Chaoyi Gu,Alicia Lork,Soodabeh Majdi et al.
Chaoyi Gu et al.
During the past decade, emerging studies using electrochemistry and nanoscale imaging have demonstrated that partial exocytotic release is prevailing in neuroendocrine cell models. However, due to complicated structure and culture process, ...
Mass spectrometry integrates protein design into structural biology method development [0.03%]
质谱使蛋白质设计成为结构生物学方法开发的一部分
Alexander Stevens,Hannah Osterholz,Vsevolod Viliuga et al.
Alexander Stevens et al.
Recent advances in machine learning (ML) have transformed protein science, enabling engineering and de novo design of artificial proteins with novel structures and functions. However, experimental analysis of key design features, such as ol...
Katerina Kanevche,David Joll Burr,Janina Drauschke et al.
Katerina Kanevche et al.
Infrared (IR) nanoscopy represents a collection of imaging and spectroscopy techniques capable of resolving IR absorption on the nanometer scale. Chemical specificity is leveraged from vibrational spectroscopy, while light-matter interactio...
Bengt Nordén
Bengt Nordén
Editorial
QRB discovery. 2026 Jan 5:7:e1. DOI:10.1017/qrd.2025.10017 2026
Victor Rodríguez-Franco,Michelle Marie Spiering,Piero Bianco et al.
Victor Rodríguez-Franco et al.
DNA helicases are molecular motors that use the energy from nucleotide hydrolysis to move along DNA, promoting the unwinding or rewinding of the double helix. Here, we use magnetic and optical tweezers to track the motion of three helicases...
The low complexity linker of DNAJB6b is key to its anti-amyloid function [0.03%]
DNAJB6b的低复杂性链接区域是其抗淀粉样蛋白功能的关键区域
Timas Merkelis,Ulf Olsson,Sara Linse
Timas Merkelis
Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are associated with the formation of amyloid fibrils. The DNAJB6b (JB6) chaperone greatly inhibits the disease-related self-assembly of amyloid peptides in an ATP-in...