Daniel M Foulkes,Daniel M Cooper,Catherine Westland et al.
Daniel M Foulkes et al.
In terms of biomass, bacteria are the most successful organisms on earth. This is partly attributed to their tremendous adaptive capabilities, which allows them to sense and rapidly organise responses to changing environmental stimuli. Usin...
Visualizing stress granule dynamics with an RNA guanine quadruplex targeted ruthenium(ii) peptide conjugate [0.03%]
一种靶向RNA鸟嘌呤四联体的肽配位钌(II)化合物，用于观测应激颗粒动态变化
Rhianne C Curley,Lorcan Holden,Tia E Keyes
Rhianne C Curley
Stress granules (SGs) are membraneless ribonucleoprotein assemblies that form in response to cellular stress. They have been linked to cell survival and cancer progression, though many questions remain regarding their structure, function an...
A biparatopic HER2-targeting ADC constructed via site-specific glycan conjugation exhibits superior stability, safety, and efficacy [0.03%]
一种通过特异性糖基定点偶联的双靶点HER2抗体药物偶联物，表现出优异的稳定性、安全性和疗效
Qi Xue,Jianjian Peng,Wenying Dai et al.
Qi Xue et al.
HER2 is overexpressed in approximately 15-20% of cancers and is associated with aggressive disease progression. We developed JSKN003, a bispecific HER2-targeted antibody-drug conjugate (ADC), through site-specific conjugation technology bas...
Mark E Kowalewski,Matthew R Redinbo
Mark E Kowalewski
The human gut microbiota has been linked to numerous diseases through their metabolism of molecules in the gastrointestinal tract. Post-translational glycosylation is applied to many secreted proteins, including mucins and immunoglobulins, ...
Exploring marine glycans: structure, function, and the frontier of chemical synthesis [0.03%]
探索海洋糖类：结构、功能及其合成最前沿
Sandhya Mardhekar,Phuong Luong,Peter H Seeberger
Sandhya Mardhekar
Marine glycans are structurally diverse biomolecules that play pivotal roles in oceanic carbon cycling by regulating microbial metabolism, accelerating organic matter turnover, and contribute to carbon sequestration. Glycans originating fro...
Quantitative neuropeptide analysis by mass spectrometry: advancing methodologies for biological discovery [0.03%]
定量质谱法分析神经肽：用于生物发现的先进技术方法论
Angel Erbey Ibarra,Wenxin Wu,Haoran Zhang et al.
Angel Erbey Ibarra et al.
Neuropeptides are critical endogenous signaling molecules involved in a wide range of biological processes, including neurotransmission, hormonal regulation, immune responses, and stress management. Despite their importance, the field of ne...
Correction: Proximity-induced SuFEx increases the potency of cytosolic nucleotidase inhibitors and reveals a rare example of covalently targeted histidine [0.03%]
纠正：诱导SuFEx可增加细胞质核苷酸酶抑制剂的活性，并揭示罕见的共价靶向组氨酸的例子
Mikolaj Chrominski,Marcin Warminski,Mateusz Kozarski et al.
Mikolaj Chrominski et al.
[This corrects the article DOI: 10.1039/D5CB00005J.]. This journal is © The Royal Society of Chemistry.
Published Erratum
RSC chemical biology. 2025 Jun 12. DOI:10.1039/d5cb90025e 2025
Metal-mediated peptide processing. How copper and iron catalyze diverse peptide modifications such as amidation and crosslinking [0.03%]
金属介导的肽加工。铜和铁如何催化酰胺化和交联等多样的肽修饰反应
Ninian J Blackburn
Ninian J Blackburn
Peptide processing is an important post-translational function that converts newly synthesized pro-peptides into their biologically active mature forms. In this review we discuss two such processes, peptide amidation and ribosomally synthes...
Biochemical characterization of Bifidobacterium bifidum peptidoglycan d,l-endopeptidase BbMep that generates NOD2 ligands [0.03%]
枯草杆菌肽双歧杆菌BbMep（d,l-ends肽酶）的生化表征可生成NOD2配体
Jeric Mun Chung Kwan,Shiliu Feng,Evan Wei Long Ng et al.
Jeric Mun Chung Kwan et al.
Soluble peptidoglycan fragments produced by the gut bacteria are key effectors in microbiota-host crosstalk. Here, we biochemically characterized BbMep, an NlpC/p60 domain-containing peptidoglycan d,l-endopeptidase from Bifidobacterium bifi...
trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity [0.03%]
通过未修改的纳米抗体连接的包含交联型环辛烯(IL-1β免疫细胞因子)的细胞因子活性的“点击-2-释放”控制体系
Amber Barendrecht,Heleen H C Peeters,Diana Torres-García et al.
Amber Barendrecht et al.
Immunocytokines have emerged as a promising modality in cancer therapy, capitalizing on the precision of antibodies to deliver cytokines selectively to tumours. Yet, the toxicity of the cytokine portion of these antibody-cytokine constructs...