Andrii Gorelik,Daan M F van Aalten
Andrii Gorelik
Protein O-GlcNAcylation is an abundant post-translational modification of intracellular proteins with the monosaccharide N-acetylglucosamine covalently tethered to serines and threonines. Modification of proteins with O-GlcNAc is required f...
Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry [0.03%]
细胞内DNA和RNA的生物正交环加成标记技术
Dorothée Ganz,Dennis Harijan,Hans-Achim Wagenknecht
Dorothée Ganz
Labelling of nucleic acids as biologically important cellular components is a crucial prerequisite for the visualization and understanding of biological processes. Efficient bioorthogonal chemistry and in particular cycloadditions fullfill ...
Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism [0.03%]
小麦病原菌Zymoseptoria tritici N-十四酰基转移酶抑制剂：靶向抗真菌活性和一种不同寻常的代谢防御机制
Roman O Fedoryshchak,Cory A Ocasio,Benjamin Strutton et al.
Roman O Fedoryshchak et al.
Zymoseptoria tritici is the causative agent of Septoria tritici blotch (STB), which costs billions of dollars annually to major wheat-producing countries in terms of both fungicide use and crop loss. Agricultural pathogenic fungi have acqui...
Hidetoshi Kajino,Tomomi Nagatani,Miku Oi et al.
Hidetoshi Kajino et al.
We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a u...
Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities [0.03%]
邻里观察：定义位置依赖的亚蛋白组及其上下文信号传导活性的工具
Marcus J C Long,Yi Zhao,Yimon Aye
Marcus J C Long
Transient associations between numerous organelles-e.g., the endoplasmic reticulum and the mitochondria-forge highly-coordinated, particular environments essential for cross-compartment information flow. Our perspective summarizes chemical-...
Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a [0.03%]
与Wnt3a相互作用抑制Wnt信号的巨环肽
Manuel E Otero-Ramirez,Kyoko Matoba,Emiko Mihara et al.
Manuel E Otero-Ramirez et al.
Here we report de novo macrocyclic peptide binders to Wnt3a, a member of the Wnt protein family. By means of the Random non-standard Peptides Integrated Discovery (RaPID) system, we have performed in vitro selection against the complex of m...
A mechanism-inspired UDP- N-acetylglucosamine pyrophosphorylase inhibitor [0.03%]
机制启发的UDP-N-乙酰葡萄糖胺焦磷酸化酶抑制剂
Olawale G Raimi,Ramon Hurtado-Guerrero,Vladimir Borodkin et al.
Olawale G Raimi et al.
UDP-N-acetylglucosamine pyrophosphorylase (UAP1) catalyses the last step in eukaryotic biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), converting UTP and GlcNAc-1P to the sugar nucleotide. Gene disruption studies have ...
Welcome to the inaugural issue of RSC Chemical Biology, a Gold open-access journal dedicated to publishing breakthrough research at the interface of chemistry and biology. ...
Recent Developments and Applications of Quantitative Proteomics Strategies for High-Throughput Biomolecular Analyses in Cancer Research [0.03%]
高通量生物分子分析在癌症研究中的定量蛋白质组学策略的最新进展及应用
Hannah N Miles,Daniel G Delafield,Lingjun Li
Hannah N Miles
Innovations in medical technology and dedicated focus from the scientific community have inspired numerous treatment strategies for benign and invasive cancers. While these improvements often lend themselves to more positive prognoses and g...
Biological functions of supramolecular assemblies of small molecules in cellular environment [0.03%]
小型分子细胞内超分子复合物的生物学功能研究进展
Jingyu Wang,Hui Li,Bing Xu
Jingyu Wang
Like biomacromolecules, certain small molecules (e.g., aggregators) are able to self-assemble in aqueous phase to form nanoscale aggregates. Though it is well-established that the aggregates may interact with enzymes in vitro, the study of ...