Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint [0.03%]
利用PD-L1接口肽进行PD-1免疫检查点的正电子发射断层显影成像
Kuan Hu,Lin Xie,Masayuki Hanyu et al.
Kuan Hu et al.
Interface peptides that mediate protein-protein interactions (PPI) are a class of important lead compounds for designing PPI inhibitors. However, their potential as precursors for radiotracers has never been exploited. Here we report that t...
Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping [0.03%]
曲普林对单胺氧化酶的特异性因其蛋白质非特异性标记和溶酶体捕获作用而受限
Jonas Drechsel,Christina Kyrousi,Silvia Cappello et al.
Jonas Drechsel et al.
Monoamine oxidases MAOA and MAOB catalyze important cellular functions such as the deamination of neurotransmitters. Correspondingly, MAO inhibitors are used for the treatment of severe neuropsychiatric disorders such as depression. A commo...
Cellular internalization mechanism of novel Raman probes designed for plant cells [0.03%]
新型拉曼探针的植物细胞内吞机制研究
Keiko Midorikawa,Kousuke Tsuchiya,Simon Sau Yin Law et al.
Keiko Midorikawa et al.
Diphenylacetylene derivatives containing different polymeric components, poly(l-lysine) (pLys) or tetra(ethylene glycol) (TEG) were designed as novel Raman imaging probes with high Raman sensitivity and low cytotoxicity in living plant cell...
Heleen de Jong,Kimberly M Bonger,Dennis W P M Löwik
Heleen de Jong
An important hurdle for the intracellular delivery of large cargo is the cellular membrane, which protects the cell from exogenous substances. Cell-penetrating peptides (CPPs) can cross this barrier but their use as drug delivery vehicles i...
Harnessing cyclotides to design and develop novel peptide GPCR ligands [0.03%]
利用环肽设计和开发新型多肽G蛋白偶联受体配体
Edin Muratspahić,Johannes Koehbach,Christian W Gruber et al.
Edin Muratspahić et al.
Cyclotides are plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot topology that confers them with remarkable structural stability and resistance to proteolytic degradation. Recently, cyclotides have emerged as p...
The chemical biology of IL-12 production via the non-canonical NFkB pathway [0.03%]
非经典NF-kB途径介导的IL-12生成机制研究
Peter D Koch,Mikael J Pittet,Ralph Weissleder
Peter D Koch
Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors. Given these multiple modes of actions, iden...
Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases [0.03%]
用于纤维素酶的糖基环磷酸酯衍活性位点探针和抑制剂
Casper de Boer,Nicholas G S McGregor,Evert Peterse et al.
Casper de Boer et al.
Cellulases and related β-1,4-glucanases are essential components of lignocellulose-degrading enzyme mixtures. The detection of β-1,4-glucanase activity typically relies on monitoring the breakdown of purified lignocellulose-derived substr...
Antibacterial activity of a dual peptide targeting the Escherichia coli sliding clamp and the ribosome [0.03%]
一种双重抗菌肽对抗细菌增殖过程两个不同步骤的靶向作用研究
Christophe André,Florian Veillard,Philippe Wolff et al.
Christophe André et al.
The bacterial processivity factor, or sliding clamp (SC), is a target of choice for new antibacterial drugs development. We have previously developed peptides that target Escherichia coli SC and block its interaction with DNA polymerases in...
Haemoglobin(βK120C)-albumin trimer as an artificial O2 carrier with sufficient haemoglobin allostery [0.03%]
具有足够变构效应的血红蛋白-白蛋白三聚体作为人工氧载体:Hb(βK120C)-白蛋白三聚体
Yoshitsugu Morita,Asuka Saito,Jun Yamaguchi et al.
Yoshitsugu Morita et al.
The allosteric O2 release of haemoglobin (Hb) allows for efficient O2 delivery from the lungs to the tissues. However, allostery is weakened in Hb-based O2 carriers because the chemical modifications of the Lys- and Cys-β93 residues preven...
Julian D Hegemann,Roderich D Süssmuth
Julian D Hegemann
Lanthipeptides belong to the superfamily of ribosomally-synthesized and posttranslationally-modified peptides (RiPPs). Despite the fact that they represent one of the longest known RiPP subfamilies, their youngest members, classes III and I...