Generation of glucosylated sn-1-glycerolphosphate teichoic acids: glycerol stereochemistry affects synthesis and antibody interaction [0.03%]
葡萄糖化sn-1-甘油磷壁酸的生成：甘油立体化学影响合成和抗体相互作用
Francesca Berni,Liming Wang,Ermioni Kalfopoulou et al.
Francesca Berni et al.
Lipoteichoic acids (LTAs) have been addressed as possible antigen candidates for vaccine development against several opportunistic Gram-positive pathogens. The study of structure-immunogenicity relationship represents a challenge due to the...
A two-step resin based approach to reveal survivin-selective fluorescent probes [0.03%]
一种两步树脂法揭示survivin选择性荧光探针
Andrew J Ambrose,Nhan T Pham,Jared Sivinski et al.
Andrew J Ambrose et al.
The identification of modulators for proteins without assayable biochemical activity remains a challenge in chemical biology. The presented approach adapts a high-throughput fluorescence binding assay and functional chromatography, two prot...
Xinyang Li,Jian-Ming Lv,Dan Hu et al.
Xinyang Li et al.
Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetylenic products used in the fields of medicinal chemistry, organic synthesis and material scien...
Strategies to expand peptide functionality through hybridisation with a small molecule component [0.03%]
通过与小分子组分杂交扩展肽功能性的策略
Yuteng Wu,Jack Williams,Ewen D D Calder et al.
Yuteng Wu et al.
Combining different compound classes gives molecular hybrids that can offer access to novel chemical space and unique properties. Peptides provide ideal starting points for such molecular hybrids, which can be easily modified with a variety...
Modified internucleoside linkages for nuclease-resistant oligonucleotides [0.03%]
用于制备耐核酸酶寡核苷酸的修饰介导的糖磷酸骨架连接体
Guillaume Clavé,Maeva Reverte,Jean-Jacques Vasseur et al.
Guillaume Clavé et al.
In the past few years, several drugs derived from nucleic acids have been approved for commercialization and many more are in clinical trials. The sensitivity of these molecules to nuclease digestion in vivo implies the need to exploit resi...
Immunopharmacotherapeutic advancements in addressing methamphetamine abuse [0.03%]
methamphetamine滥用的免疫药理治疗进展
Jinny Claire Lee,Kim D Janda
Jinny Claire Lee
Methamphetamine (METH) is an illicit psychostimulant that is known to account for substance abuse disorders globally, second only to opioids, yet has no approved pharmacotherapies. Traditional therapies employ small molecule agonists or ant...
Suprama Datta,Erik C Hett,Kalpit A Vora et al.
Suprama Datta et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic that has led to a global economic disruption and collapse. With several ongoing efforts to develop vacc...
Samya Banerjee,Peter J Sadler
Samya Banerjee
Hydrogenation reactions in biology are usually carried out by enzymes with nicotinamide adenine dinucleotide (NAD(P)H) or flavin mononucleotide (FAMH2)/flavinadenine dinucleotide (FADH2) as cofactors and hydride sources. Industrial scale ch...
Hiroaki Suga
Hiroaki Suga
News from Hiroaki Suga, the Editorial Board Chair of RSC Chemical Biology. This journal is © The Royal Society of Chemistry.
Combining bacteriophage engineering and linear dichroism spectroscopy to produce a DNA hybridisation assay [0.03%]
结合噬菌体工程和线性双色谱学产生DNA杂交分析法
Aysha Ali,Haydn A Little,Jake G Carter et al.
Aysha Ali et al.
Nucleic acid detection is an important part of our bio-detection arsenal, with the COVID-19 pandemic clearly demonstrating the importance to healthcare of rapid and efficient detection of specific pathogenic sequences. As part of the drive ...