Fluorescent proteins of the EosFP clade: intriguing marker tools with multiple photoactivation modes for advanced microscopy [0.03%]
EosFP亚科的荧光蛋白：多种光活化模式的先进显微镜标记工具
Karin Nienhaus,Gerd Ulrich Nienhaus
Karin Nienhaus
Optical fluorescence microscopy has taken center stage in the exploration of biological structure and dynamics, especially on live specimens, and super-resolution imaging methods continue to deliver exciting new insights into the molecular ...
Chemogenomics for drug discovery: clinical molecules from open access chemical probes [0.03%]
化学基因组学在药物发现中的应用：来自开放获取的化学探针的临床分子
Robert B A Quinlan,Paul E Brennan
Robert B A Quinlan
In recent years chemical probes have proved valuable tools for the validation of disease-modifying targets, facilitating investigation of target function, safety, and translation. Whilst probes and drugs often differ in their properties, th...
Recent development of near-infrared photoacoustic probes based on small-molecule organic dye [0.03%]
基于小分子有机染料的近红外光声探针的研究进展
Chonglu Li,Chang Liu,Yifan Fan et al.
Chonglu Li et al.
Photoacoustic imaging (PAI), which integrates the higher spatial resolution of optical imaging and the deeper penetration depth of ultrasound imaging, has attracted great attention. Various photoacoustic probes including inorganic and organ...
We would like to take this opportunity to highlight the Outstanding Reviewers for RSC Chemical Biology in 2020, as selected by the editorial team for their significant contribution to the journal. ...
Combined computational and intracellular peptide library screening: towards a potent and selective Fra1 inhibitor [0.03%]
计算与细胞内肽联合筛选：开发高效的Fra1抑制剂
Miao Yu,Lila Ghamsari,Jim A Rotolo et al.
Miao Yu et al.
To date, most research into the inhibition of oncogenic transcriptional regulator, Activator Protein 1 (AP-1), has focused on heterodimers of cJun and cFos. However, the Fra1 homologue remains an important cancer target. Here we describe li...
Substrate inhibition by the blockage of product release and its control by tunnel engineering [0.03%]
产物释放受阻的底物抑制及其通道工程控制机制研究
Piia Kokkonen,Andy Beier,Stanislav Mazurenko et al.
Piia Kokkonen et al.
Substrate inhibition is the most common deviation from Michaelis-Menten kinetics, occurring in approximately 25% of known enzymes. It is generally attributed to the formation of an unproductive enzyme-substrate complex after the simultaneou...
Protein degradation profile reveals dynamic nature of 20S proteasome small molecule stimulation [0.03%]
蛋白质降解图谱揭示了20S蛋白酶体小分子刺激的动态性质
Rachel A Coleman,Rodrigo Mohallem,Uma K Aryal et al.
Rachel A Coleman et al.
Small molecules have been discovered to stimulate the 20S core particle (CP) of the proteasome to degrade proteins. However, the impact a 20S CP stimulator can have on the regulation of protein levels has not been fully characterized. Previ...
Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase [0.03%]
线粒体靶向的人类SIRT3赖氨酸去乙酰酶抑制剂
Kathrin S Troelsen,Michael Bæk,Alexander L Nielsen et al.
Kathrin S Troelsen et al.
Sirtuin 3 (SIRT3) is the major protein lysine deacetylase in the mitochondria. This hydrolase regulates a wide range of metabolically involved enzymes and has been considered as a potential drug target in certain cancers. Investigation of p...
Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration [0.03%]
SIRT2靶点的机制抑制剂：构效关系，晶体结构，作用验证，α-微管蛋白乙酰化水平调节及乳腺癌细胞迁移抑制作用研究
Alexander L Nielsen,Nima Rajabi,Norio Kudo et al.
Alexander L Nielsen et al.
Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug t...
Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein [0.03%]
膜的组成和脂质与蛋白质比率调节酵母朊蛋白淀粉样蛋白动力学
Arnab Bandyopadhyay,Achinta Sannigrahi,Krishnananda Chattopadhyay
Arnab Bandyopadhyay
Understanding of prion aggregation in a membrane environment may help to ameliorate neurodegenerative complications caused by the amyloid forms of prions. Here, we investigated the membrane binding-induced aggregation of yeast prion protein...