Covalent aptamers: agents with promising therapeutic and diagnostic potential [0.03%]
共价连接的适配体：具有治疗和诊断潜力的生物制剂
Savannah Albright,Jessica Boette,Mary Cacace et al.
Savannah Albright et al.
Small molecule- and antibody-based approaches have shown tremendous success in both therapeutic and diagnostic applications. Aptamers, which are engineered nucleic acid ligands for proteins, have not found similar broad applicability, poten...
Investigating the utilization mechanism and kinetics of sialic acid mimetics in mammalian cell lines [0.03%]
模拟唾液酸利用机制及动力学的哺乳动物细胞系研究
Eline A Visser,Daniël L A H Hornikx,Moritz Rahm et al.
Eline A Visser et al.
Sialic acid mimetics (SAMs) are chemically modified derivatives of sialic acids that can act as metabolic inhibitors or as sugar donors for sialyltransferases. This makes SAMs highly useful research tools to study and manipulate the biosynt...
Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders [0.03%]
HIV-1病毒蛋白R衍生肽作为新型E3泛素连接酶结合成分的BRD4降解剂的研究与应用
Kohei Tsuji,Xueyuan Huang,Maho Miyamoto et al.
Kohei Tsuji et al.
Proteolysis targeting chimeras (PROTACs) have become a new modality for drug development of particular importance for cancer chemotherapy. PROTACs are composed of a ligand that binds to the protein of interest (POI) tethered by a linker to ...
A disubstituted aniline probe for enhanced peroxidase-based proximal protein labelling [0.03%]
一种用于增强过氧化物酶介导的近端蛋白质标记的二取代苯胺探针
Pornchai Kaewsapsak,Nattavorapon Tantisasirat,Sucheewin Krobthong et al.
Pornchai Kaewsapsak et al.
Proteins are biomolecules essential for cellular functions, including cell signaling and regulation. Protein misfolding or mislocalisation can result in various diseases. Peroxidase-mediated proximity labelling has emerged as a powerful too...
Affinity-based protein profiling of the antiviral natural product nanchangmycin [0.03%]
基于亲和力的抗病毒天然产物南川霉素蛋白质靶点鉴定
Santiago Leiva,Chloé Freyermuth,Stéphane Claverol et al.
Santiago Leiva et al.
Nanchangmycin is a natural product with broad-spectrum activity against various organisms, exhibiting antibiotic, antiviral, anticancer, and antifibrotic effects. Nanchangmycin belongs to the family of polyether ionophores and is proposed t...
Agrima Deedwania,Yi Wang,Carol V Robinson et al.
Agrima Deedwania et al.
Membrane proteins and lipids are essential for a wide range of cellular processes, making their structural characterisation essential for understanding biological function. However, the amphipathic nature of membrane proteins poses a signif...
Programmable synthesis of alkaloidal frameworks integrating Michael acceptor generates covalent probes for targeting POLE3 in HBV replication [0.03%]
可编程合成阿片类框架整合迈克尔接受者生成共价探针以靶向HBV复制中的POLE3
Nobuto Kaneko,Misao Himeno,Yuhi Kobayashi et al.
Nobuto Kaneko et al.
The growing need for effective HBV treatments and lead compounds with novel mechanisms prompted us to explore synthetic strategies for generating skeletally diverse alkaloidal Michael acceptors. Our approach uniquely embeds Michael acceptor...
Screening and machine learning-based prediction of translation-enhancing peptides that reduce ribosomal stalling in Escherichia coli [0.03%]
筛选并基于机器学习预测减少大肠杆菌核糖体停滞的翻译增强肽
Teruyo Ojima-Kato,Gentaro Yokoyama,Hideo Nakano et al.
Teruyo Ojima-Kato et al.
We previously reported that the nascent SKIK peptide enhances translation and alleviates ribosomal stalling caused by arrest peptides (APs) such as SecM and polyproline when positioned immediately upstream of the APs in both Escherichia col...
A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition [0.03%]
PAF1与ENL/AF9YEATS抑制之间的化学遗传相互作用
Paige A Barta,Leopold Garnar-Wortzel,Timothy R Bishop et al.
Paige A Barta et al.
Transcriptional regulatory proteins are frequent drivers of oncogenesis and common targets for drug discovery. The transcriptional co-activator, ENL, which is localized to chromatin through its acetyllysine-binding YEATS domain, is preferen...
Comparative aptamer profiling reveals cell surface remodeling and the emergence of a noncanonical cell surface protein under oncogenic signaling [0.03%]
比较性适配体特征分析揭示了致癌信号传导下的细胞表面重塑及非典型细胞表面蛋白的出现
Jungo Kakuta,Kenji Ohba,Hideaki Ogasawara et al.
Jungo Kakuta et al.
Identifying cell type-specific molecular markers on the cancer cell surface is essential for understanding cancer progression and for discovering critical neoantigens relevant to immunotherapy. Nucleic acid aptamers serve as powerful tools ...