The role of water in mediating DNA structures with epigenetic modifications, higher-order conformations and drug-DNA interactions [0.03%]
水在介导表观遗传修饰、高阶结构和药物与DNA相互作用的DNA结构中的作用
Roshan Satange,Ming-Hon Hou
Roshan Satange
Water is arguably one of the most important chemicals essential for the functioning of biological molecules. In the context of DNA, it plays a crucial role in stabilizing and modulating its structure and function. The discovery of water-bou...
Peptide-mediated display of Tau-derived peptide for construction of microtubule superstructures [0.03%]
Tau衍生肽的肽介导展示用于构建微管超结构
Hiroshi Inaba,Daichi Kageyama,Soei Watari et al.
Hiroshi Inaba et al.
Microtubules are major cytoskeletons involved in various cellular functions, such as regulating cell shape and division and cargo transport via motor proteins. In addition to widely studied singlet microtubules, complex microtubule superstr...
Real-time bioluminescence imaging of nitroreductase in breast cancer bone metastasis [0.03%]
乳腺癌骨转移中实时发光成像硝基还原酶
Kang Lu,Mengxi Zhang,Zuotong Tian et al.
Kang Lu et al.
Bone metastasis is a leading cause of mortality in breast cancer patients. Monitoring biomarkers for bone metastasis in breast cancer is crucial for the development of effective interventional treatments. Despite being a highly vascularized...
Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases [0.03%]
Epichaperomes：重新定义复杂疾病中的分子伴娘生物学及治疗策略
Chiranjeevi Pasala,Chander S Digwal,Sahil Sharma et al.
Chiranjeevi Pasala et al.
The complexity of disease biology extends beyond mutations or overexpression, encompassing stress-induced mechanisms that reshape proteins into pathological assemblies. Epichaperomes, stable and disease-specific assemblies of chaperones and...
Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-β peptide [0.03%]
神经节苷脂脂质抑制阿尔茨海默病淀粉样-β肽的聚集
Zenon Toprakcioglu,Akhila K Jayaram,Tuomas P J Knowles
Zenon Toprakcioglu
The aggregation of the amyloid-β (Aβ) peptides (Aβ42/Aβ40) into amyloid fibrils and plaques is one of the molecular hallmarks in dementia and Alzheimer's disease (AD). While the molecular mechanisms behind this aggregation process are n...
Özge Simsir,Tobias Walter,Hanife Sahin et al.
Özge Simsir et al.
Epigenetic regulation of gene expression is essential for cellular development and differentiation processes in higher eukaryotes. Modifications of cytosine, in particular 5-methylcytosine (5mdC), in DNA play a central role through impactin...
Identification of microproteins with transactivation activity by polyalanine motif selection [0.03%]
通过多聚丙氨酸基序选择鉴定具有转激活活性的微蛋白
Archita Agrawal,Alan Saghatelian
Archita Agrawal
Microproteins are an emerging class of proteins that are encoded by small open reading frames (smORFs) less than or equal to 100 amino acids. The functions of several microproteins have been illuminated through phenotypic screening or prote...
Huiting Liang,Yun Xing,Kexin Wang et al.
Huiting Liang et al.
mRNA-based therapies have broad applications in various disease treatments and have been applied in protein replacement therapy, gene editing, and vaccine development. Numerous research studies have been carried out aiming to increase the s...
Regulating ferredoxin electron transfer using nanobody and antigen interactions [0.03%]
使用纳米体和抗原相互作用调节铁氧还蛋白的电子转移
Albert Truong,Jonathan J Silberg
Albert Truong
Fission and fusion can be used to generate new regulatory functions in proteins. This approach has been used to create ferredoxins (Fd) whose cellular electron transfer is dependent upon small molecule binding. To investigate whether Fd fra...
Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues [0.03%]
由FKBP12、MAPRE1和大环分子胶水组成的三元复合物的识别与特征分析
Michael Salcius,Antonin Tutter,Marianne Fouché et al.
Michael Salcius et al.
Many disease-relevant and functionally well-validated targets are difficult to drug. Their poorly defined 3D structure without deep hydrophobic pockets makes the development of ligands with low molecular weight and high affinity almost impo...