Does sod1 encode a molecular clock? Mutations that mimic asparagine deamidation inhibit heterodimerization with ALS-mutant SOD1 [0.03%]
SOD1是否编码一种分子钟？模拟天冬酰胺脱氨基的突变抑制了与ALS突变SOD1的异二聚化作用
Mayte Gonzalez,Travis J Lato,Emily A Alonzo et al.
Mayte Gonzalez et al.
The self-exchange of subunits by protein homodimers is a common protein-protein interaction in vivo. In heterozygous genetic disorders involving homodimeric gene products, both mutant and WT proteins can exchange subunits (heterodimerize). ...
Manoj Kumar Gupta,Salam Maree,Eylon Yavin
Manoj Kumar Gupta
A variety of oligonucleotide-based probes have been developed for specific and selective sensing of RNA and DNA. Among these, FIT-PNAs (forced intercalation-peptide nucleic acids) and FIT probes (DNA- and RNA-based sensors) have been studie...
Double-hit approach for novel glycoconjugates combining cytoplasmic glycoengineering and selective chemistry [0.03%]
结合细胞质型糖工程和选择性化学的双功能新型糖缀合物合成方法学研究
Elena Palmieri,Valentina Monaci,Salvatore Durante et al.
Elena Palmieri et al.
Chemical conjugation to carrier proteins has been traditionally used to improve polysaccharides immunogenicity and to overcome the limitations of T-independent antigens, including lack of immunological memory and efficacy in infants. A doub...
Correction: Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation [0.03%]
订正：蛋白降解靶向嵌合体（PROTAC）迎来了而立之年：特异性蛋白质降解步入第三个十年
Michael J Bond,Craig M Crews
Michael J Bond
[This corrects the article DOI: 10.1039/D1CB00011J.]. This journal is © The Royal Society of Chemistry.
Published Erratum
RSC chemical biology. 2026 Jan 5. DOI:10.1039/d5cb90053k 2026
A nonavalent BODIPY with a multivalent arrangement of α-mannosides enables lectins recognition in fluorescence-based assays [0.03%]
一种α-岩藻糖苷多重价非纳米BODIPY在基于荧光的试验中实现对多糖的识别
Giacomo Biagiotti,Edvin Purić,Jacopo Tricomi et al.
Giacomo Biagiotti et al.
We report here the use of Tris-BODIPY-OH as a scaffold for the multivalent display of sugar heads. A chloroacetyl thioether ligation reaction easily yields mannosylated BODIPYs, named Man9-BODIPY and (Man-TEG)9-BODIPY, which display nine ma...
Zhengnian Li,Michael Martinez,Woong Sub Byun et al.
Zhengnian Li et al.
Enzymatically activated prodrugs can enable context-specific target inhibition. AKR1C3 is an NADPH-dependent aldo-ketoreductase involved in androgen metabolism, prostaglandin synthesis, and cell proliferation that is overexpressed in tumors...
Protein mannosylation in actinobacteria an enigmatic post-translational modification [0.03%]
放线菌中的蛋白质甘露糖化是一种神秘的翻译后修饰
Cameron B King,Warren W Wakarchuk
Cameron B King
Protein glycosylation is a very common post-translational modification seen in all branches of biology. The functional roles for protein glycosylation are many and varied, essential in eukaryotes but seemingly dispensable in bacteria. One g...
Backbone engineering in the hydrophobic core of villin headpiece [0.03%]
蛋白分子中的疏水核区域骨干工程研究——以villin头部片段为例
Yuhan Lin,Ryley M David,Dyllan M Amin et al.
Yuhan Lin et al.
Changing the backbone connectivity of proteins can impart useful new traits while maintaining essential structural and functional features. In design of artificial proteomimetic agents, backbone modification is usually isolated to sites tha...
Expanding the actinomycetes landscape for phosphonate natural products through genome mining [0.03%]
利用基因组挖掘技术扩大链霉菌产生磷叶酸类天然产物的谱系范围
Alina Zimmermann,Shu-Ning Xia,Julia Moschny et al.
Alina Zimmermann et al.
Phosphonate natural products (P-NPs) represent a unique and underexplored class of bioactive compounds with significant pharmaceutical and biotechnological potential. Many novel P-NPs with promising bioactivities were identified in recent y...
Tuning the efficiency of molecular probes via quinone methide-based in situ labeling [0.03%]
基于倍半ketone基的原位标记调节分子探针的效率
Zachary Rabinowitz,Seyedehalaleh Anvar,Jun Liu et al.
Zachary Rabinowitz et al.
Imaging the activities of hydrolases using molecular imaging probes can reveal underlying molecular mechanisms in the context of cells to organisms and their correlation with different pathological conditions can be used in diagnosis. Due t...