Amrita Date,Archie Wall,Hannah Kiely-Collins et al.
Amrita Date et al.
The dysregulation of protein-protein interactions (PPIs) in disease states is well established, yet they are challenging to target, owing to the large surface area and featureless nature of protein binding interfaces. For targeting helix-me...
Characterization of novel cofactorless self-cleaving RNAs with activity at low pH [0.03%]
具有低pH活性的新型无辅因子自切割RNA的特征研究
Nae Sakimoto,Emily Matsusaka,Natsuki Doi et al.
Nae Sakimoto et al.
Several diseases abnormally lower cellular pH owing to metabolic pathway changes. Developing drugs based on genetic material that act only in target tissues may reduce side effects by exploiting the differences between diseased and normal t...
Ant abaecin-2 is a context-dependent copper-binding effector that can be either inhibitory or protective [0.03%]
abaecin-2抗菌肽是铜依赖性结合蛋白，可以抑制也可保护真菌感染肠道的宿主健康
Caroline M Donaghy,Helena V Heyer-Gray,Charlotte O&#x;Hern et al.
Caroline M Donaghy et al.
Host defense peptides (HDPs) are important components of the innate immune system that are used to combat pathogens and often rely on binding trace nutrient metals for their function. However, controlling nutrient metals may have other role...
Yi Yang,Takayoshi Awakawa,Ikuro Abe
Yi Yang
Orthoesters are unique functional groups consisting of three alkoxy substituents attached to a central carbon atom, which endow orthoester-bearing compounds with structural complexity and therapeutically valuable bioactivity. As orthoester ...
Dissecting the functional divergence of DCAF11 isoforms in protein degradation [0.03%]
分析DCAF11不同亚型在蛋白质降解中的功能差异
Xiaokang Jin,Xiaoyu Zhang
Xiaokang Jin
DCAF11 is a substrate receptor of the Cullin-RING ligase 4 (CRL4) ubiquitin ligase complex and an emerging effector supporting targeted protein degradation. DCAF11 exists as two major isoforms, but their functional differences remain incomp...
Jacob Byerly-Duke,Sarah M Bernhard,Rida Ibrahim et al.
Jacob Byerly-Duke et al.
The therapeutic potential of peptides is severely limited by rapid metabolism mediated by proteases. Traditional stabilization strategies often compromise pharmacological profiles by disrupting native conformation or physicochemical propert...
Advances in monitoring mammalian circadian components and their rhythms using reporter systems [0.03%]
运用报告系统监测哺乳动物昼夜成分及其节律的进展
Bhavna Kalyanaraman,Emmanuel F Rivera-Iglesias,Michelle E Farkas
Bhavna Kalyanaraman
Circadian rhythms are innate biological processes that cycle over periods of approximately 24 hours and are crucial in regulating many physiological and metabolic functions. At the molecular level in mammals, these cell-autonomous oscillati...
Exclusion of RNA-binding domains from G-quadruplex condensates by G-quadruplex ligands [0.03%]
G-四链体结合配体使RNA结合域从G-四链体凝集物中解离出去
Yoshiki Hashimoto,Ryosuke Suzuki,Mizuho Aya et al.
Yoshiki Hashimoto et al.
Biomolecular liquid-liquid phase separation, which forms droplets in living cells, plays a crucial role in the regulation of gene expression. Dysfunction of liquid-liquid phase separation leads to aberrant aggregates that sequester RNA-bind...
NovaID: photocatalytic proximity labeling with an engineered HyperNova [0.03%]
NovaID：利用工程化HyperNova进行光催化临近标记
Jianbei Zhu,Ziyuan Wang,Qishuo Zheng et al.
Jianbei Zhu et al.
Photocatalytic proximity labeling has transformed the mapping of local molecular environments in living cells, but many existing platforms depend on flavin, heme, or metal cofactors, limiting their broader deployment. Here we repurpose Hype...
Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress [0.03%]
自由基在氧化和炎症压力下对哺乳动物细胞核糖体RNA触角的损害作用
Aaron M Fleming,Justin C Dingman,Cynthia J Burrows
Aaron M Fleming
Chemical damage to ribosomal RNA (rRNA) during oxidative or inflammatory stress can impact protein synthesis. Human cells were exposed to an H2O2 titration to induce oxidative stress, or tumor necrosis factor-α (TNF-α) over a time course ...