Meta-inflammation through the lens of macrophage programming and nutrient-sensing ghrelin signaling [0.03%]
巨噬细胞程序和营养感知胃泌素信号传导视角下的.meta炎症反应
Hye Won Han,Da Mi Kim,Sahar Eshghjoo et al.
Hye Won Han et al.
Macrophages are at the critical interface of immunity and metabolism. Metabolic reprogramming of macrophages, also known as meta-inflammation, has major implications in the pathogenesis of many chronic diseases. The infiltration and polariz...
Tissue-specific roles of monoacylglycerol (MAG) in metabolic diseases [0.03%]
单酰基甘油（MAG）在代谢性疾病中的组织特异性作用
Min Young Park,Ashley Mooring,Joanne Bruno et al.
Min Young Park et al.
Monoacylglycerol (MAG) is an important bioactive lipid metabolite/intermediate, playing crucial roles in energy homeostasis and cellular signaling. This review explores MAG's chemical structure, classification, and metabolic pathways. We al...
Mitochondrial reactive oxygen species regulate HIF-1α stabilization and methylglyoxal accumulation in classically activated mouse macrophages [0.03%]
线粒体反应性氧中间体调节经典激活的小胶质细胞中HIF-1α稳定及甲基甘油醛的累积
Daniel Prantner,Mark A Watson,Martin D Brand et al.
Daniel Prantner et al.
Background: The economic and medical burden of sepsis worldwide underscores the need for novel therapeutics. Early sepsis involves dramatic metabolic changes. Classically activated macrophages, stimulated with lipopolysac...
Lipid-driven epigenetic exhaustion: linking palmitate metabolism to CD8+ T-cell dysfunction in cancer [0.03%]
脂质引起的表观遗传衰竭：将棕榈酸代谢与癌症中的CD8⁺T细胞功能障碍联系起来
Desh Raj,Mahesh Kathania,Tuoqi Wu et al.
Desh Raj et al.
In a recent study published in Science Immunology, Tiberti and colleagues demonstrate that palmitate, a saturated fatty acid enriched in tumors, directly impairs CD8+ cytotoxic T lymphocyte function through mitochondrial and epigenetic repr...
A loss of the cytosolic branched-chain aminotransferase, BCATc, enhances Th1 differentiation and skews Tregs to acquire a Th1-like phenotype [0.03%]
胞液支链氨基酸转氨酶BCATc的丢失可增强Th1分化并使Treg细胞获得类似Th1表型
Tanner J Wetzel,Christie M Adam,Tanner J Kelm et al.
Tanner J Wetzel et al.
Background: T-cell fate and function are profoundly shaped by microenvironmental nutrient availability. The branched-chain amino acid, leucine, is essential for T-cell function, with its uptake via the solute carrier fami...
Reprogramming the diseased liver: antioxidant-engineered mRNA nanoparticles as microenvironment modulators in MAFLD [0.03%]
重新编程患病肝脏：抗氧化工程mRNA纳米颗粒作为非酒精性脂肪肝病的微环境调节剂
Matteo Ghiringhelli,Lior Zangi
Matteo Ghiringhelli
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a leading cause of hepatocellular carcinoma (HCC), driven in part by oxidative stress-induced immune dysfunction that limits the efficacy of immunotherapy. In a recent study, Y...
Mesenteric adipose tissue: from protective gatekeeper to driver of inflammatory bowel disease [0.03%]
肠系膜脂肪组织：从保护性屏障到炎症性肠病的驱动因素
Christy M Gliniak
Christy M Gliniak
Inflammatory bowel disease (IBD) defines a group of diseases, including Crohn's disease and ulcerative colitis, characterized by chronic inflammation of the gastrointestinal tract. Evidence suggests that visceral adipose tissue, particularl...
Immune checkpoint blockade targets macrophage PD-1 to exacerbate metabolic dysfunction [0.03%]
免疫检查点阻滞通过靶向巨噬细胞PD-1来加剧代谢紊乱
Zikuan Song,Christian Frezza
Zikuan Song
Immune checkpoint inhibitor therapies induce metabolic dysfunction. A study by Wu et al now pinpoints macrophage programmed cell death protein 1 (PD-1) as a key molecular mediator of the anti-PD-1 treatment-triggered exacerbation of systemi...
Konstantinos Aliazis,Vassiliki A Boussiotis
Konstantinos Aliazis
Metabolic reprogramming of T lymphocytes has a decisive role in their activation, differentiation, and functional fate commitment. Metabolic reprogramming guides not only the generation of T effector and T memory cells but also the developm...
Pathway thermodynamic analysis postulates change in glutamate metabolism as a key factor in modulating immune responses [0.03%]
路径热力学分析推定谷氨酸代谢是调节免疫反应的关键因素
Sunayana Malla,Rajib Saha
Sunayana Malla
Background: Temperature, as seen during fever, plays a pivotal role in modulating immune responses and maintaining cellular homeostasis. Shifts in temperature influence the thermodynamic feasibility of metabolic reactions...