Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation [0.03%]
TIMELESS单体型不全模仿内在PARG抑制剂敏感性并可通过核苷补充加以补救
Camilla Coulson-Gilmer,Samantha Littler,Bethany M Barnes et al.
Camilla Coulson-Gilmer et al.
A subset of cancer cells are intrinsically sensitive to inhibitors targeting PARG, the poly(ADP-ribose) glycohydrolase that degrades PAR chains. Sensitivity is accompanied by persistent DNA replication stress, and can be induced by inhibiti...
Sofia Ramalho,Anna Dopler,William James Faller
Sofia Ramalho
In the past few decades, our view of ribosomes has changed substantially. Rather than passive machines without significant variability, it is now acknowledged that they are heterogeneous, and have direct regulatory capacity. This 'ribosome ...
CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers [0.03%]
利用CRISPR-Cas9技术针对胰腺癌体细胞突变的特异性治疗
Selina Shiqing K Teh,Kirsten Bowland,Eitan Halper-Stromberg et al.
Selina Shiqing K Teh et al.
Somatic mutations are desirable targets for selective elimination of cancer, yet most are found within noncoding regions. We have adapted the CRISPR-Cas9 gene editing tool as a novel, cancer-specific killing strategy by targeting the subset...
Microsatellite break-induced replication generates highly mutagenized extrachromosomal circular DNAs [0.03%]
微卫星链间连接诱发的复制产生高度突变化的细胞器内环状DNA
Rujuta Yashodhan Gadgil,S Dean Rider Jr,Resha Shrestha et al.
Rujuta Yashodhan Gadgil et al.
Extrachromosomal circular DNAs (eccDNAs) are produced from all regions of the eucaryotic genome. We used inverse PCR of non-B microsatellites capable of forming hairpin, triplex, quadruplex and AT-rich structures integrated at a common ecto...
The shaping of mRNA translation plasticity by RNA G-quadruplexes in cancer progression and therapy resistance [0.03%]
RNA G-四链体在癌症进展和治疗抵抗中塑造mRNA翻译的可塑性
Anne Cammas,Alice Desprairies,Erik Dassi et al.
Anne Cammas et al.
Translational reprogramming in response to oncogenic signaling or microenvironmental stress factors shapes the proteome of cancer cells, enabling adaptation and phenotypic changes underlying cell plasticity, tumor progression and response t...
Non-canonical mRNA translation initiation in cell stress and cancer [0.03%]
细胞应激与癌症中的非规范性蛋白质翻译起始机制研究
Mélanie Mahé,Tiffany Rios-Fuller,Olga Katsara et al.
Mélanie Mahé et al.
The now well described canonical mRNA translation initiation mechanism of m7G 'cap' recognition by cap-binding protein eIF4E and assembly of the canonical pre-initiation complex consisting of scaffolding protein eIF4G and RNA helicase eIF4A...
Upstream open reading frames: new players in the landscape of cancer gene regulation [0.03%]
上游开放阅读框：癌症基因调控新机制
Anwesha Dasgupta,John R Prensner
Anwesha Dasgupta
The translation of RNA by ribosomes represents a central biological process and one of the most dysregulated processes in cancer. While translation is traditionally thought to occur exclusively in the protein-coding regions of messenger RNA...
FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers [0.03%]
FBXO42活性可防止多形性胶质母细胞瘤及其他肿瘤发生有丝分裂停滞、纺锤体组装检验点活化及致死性
Pia Hoellerbauer,Megan Kufeld,Sonali Arora et al.
Pia Hoellerbauer et al.
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. To identify genes differentially required for the viability of GBM stem-like cells (GSCs), we performed functional genomic lethality screens comparing GSCs and cont...
Next generation sequencing technologies to address aberrant mRNA translation in cancer [0.03%]
下一代测序技术在癌症异常翻译中的应用
Ángel-Carlos Román,Dixan A Benítez,Alba Díaz-Pizarro et al.
Ángel-Carlos Román et al.
In this review, we explore the transformative impact of next generation sequencing technologies in the realm of translatomics (the study of how translational machinery acts on a genome-wide scale). Despite the expectation of a direct correl...
Neural-net-based cell deconvolution from DNA methylation reveals tumor microenvironment associated with cancer prognosis [0.03%]
基于神经网络的DNA甲基化细胞去卷积可发现与癌症预后相关的肿瘤微环境
Yoshiaki Yasumizu,Masaki Hagiwara,Yuto Umezu et al.
Yoshiaki Yasumizu et al.
DNA methylation is a pivotal epigenetic modification that defines cellular identity. While cell deconvolution utilizing this information is considered useful for clinical practice, current methods for deconvolution are limited in their accu...