The three YTHDF paralogs and VIRMA are strong cross-histotype tumor driver candidates among m6A core genes [0.03%]
作为m6A核心基因的三种YTHDF同源物和VIRMA是强大的跨组织类型肿瘤驱动因子候选者
Eliana Destefanis,Denise Sighel,Davide Dalfovo et al.
Eliana Destefanis et al.
N6-Methyladenosine (m6A) is the most abundant internal modification in mRNAs. Despite accumulating evidence for the profound impact of m6A on cancer biology, there are conflicting reports that alterations in genes encoding the m6A machinery...
RNA kinetics influence the response to transcriptional perturbation in leukaemia cell lines [0.03%]
白血病细胞系中RNA动力学影响转录扰动的反应
Izabela Todorovski,Mary-Jane Tsang,Breon Feran et al.
Izabela Todorovski et al.
Therapeutic targeting of dysregulated transcription has emerged as a promising strategy for the treatment of cancers, such as leukaemias. The therapeutic response to small molecule inhibitors of Bromodomain-Containing Proteins (BRD), such a...
Decoding the molecular symphony: interactions between the m6A and p53 signaling pathways in cancer [0.03%]
破解分子乐章：m6A与p53信号通路在癌症中的互作关系解析
Rachel Shoemaker,Mo-Fan Huang,Ying-Si Wu et al.
Rachel Shoemaker et al.
The p53 tumor suppressor gene governs a multitude of complex cellular processes that are essential for anti-cancer function and whose dysregulation leads to aberrant gene transcription, activation of oncogenic signaling and cancer developme...
Novel insights into the role of bisphenol A (BPA) in genomic instability [0.03%]
双酚A(BPA)在基因组不稳定性中的作用的新见解
Anastasia Hale,George-Lucian Moldovan
Anastasia Hale
Bisphenol A (BPA) is a phenolic chemical that has been used for over 50 years in the manufacturing of polycarbonate and polyvinyl chloride plastics, and it is one of the highest volume chemicals produced worldwide. Because BPA can bind to a...
Correction to 'Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks' [0.03%]
“ku-dna结合抑制剂调节对dna双链断裂的dna损伤反应”一文的勘误通知书
[This corrects the article DOI: 10.1093/nar/zcad003.]. © The Author(s) 2024. Published by Oxford University Press on behalf of NAR Cancer.
Published Erratum
NAR cancer. 2024 Aug 1;6(3):zcae036. DOI:10.1093/narcan/zcae036 2024
CytoCellDB: a comprehensive resource for exploring extrachromosomal DNA in cancer cell lines [0.03%]
细胞数据库：探索癌细胞系中染色体外DNA的综合资源
Jacob Fessler,Stephanie Ting,Hong Yi et al.
Jacob Fessler et al.
Recently, the cancer community has gained a heightened awareness of the roles of extrachromosomal DNA (ecDNA) in cancer proliferation, drug resistance and epigenetic remodeling. However, a hindrance to studying ecDNA is the lack of availabl...
High-level tumour methylation of BRCA1 and RAD51C is required for homologous recombination deficiency in solid cancers [0.03%]
BRCA1和RAD51C肿瘤高甲基化与实体瘤同源重组缺陷有关
Lijun Xu,Brett Liddell,Ksenija Nesic et al.
Lijun Xu et al.
In ovarian and breast cancer, promoter methylation of BRCA1 or RAD51C is a promising biomarker for PARP inhibitor response, as high levels lead to homologous recombination deficiency (HRD). Yet the extent and role of such methylation in oth...
DNA abasic sites act as rational therapeutic targets to synergize temozolomide response in both MMR-proficient and deficient cancer [0.03%]
DNA脱氨基位点可合理地用作治疗靶标以增强MMR敏感和低敏的肿瘤细胞中替莫唑胺的抗癌活性
Achyut Bora,Ritesh Pal,Chandra Sova Mandi et al.
Achyut Bora et al.
Temozolomide (TMZ) is widely used in cancer treatment, yet resistance to this agent limits its therapeutic effectiveness, particularly in mismatch-repair (MMR) deficient cancer. Concurrently, the Base Excision Repair (BER) pathway exerts a ...
Decoding ribosome complexity: role of ribosomal proteins in cancer and disease [0.03%]
解码核糖体的复杂性：核糖体蛋白在癌症和疾病中的作用
Pedro Fuentes,Joffrey Pelletier,Antonio Gentilella
Pedro Fuentes
The ribosome is a remarkably complex machinery, at the interface with diverse cellular functions and processes. Evolutionarily conserved, yet intricately regulated, ribosomes play pivotal roles in decoding genetic information into the synth...
Francesca Aguilo,Erik Dassi
Francesca Aguilo