Effects of hydrazone-based G-quadruplex ligands on FANCJ/BRIP1-depleted cancer cells and a Caenorhabditis elegans dog-1-/- strain [0.03%]
含腙类G4配体化合物对FANCJ/BRIP1敲低肿瘤细胞及模式生物线虫dog-1突变株的影响研究
Marcello Germoglio,Federica D&#x;Aria,Giuseppe Cortone et al.
Marcello Germoglio et al.
G-quadruplex (G4) DNAs are alternative nucleic acid structures, proposed to play important roles in regulating DNA replication, gene transcription, and translation. Several specialized DNA helicases are involved in cellular G4 metabolism, i...
Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype [0.03%]
组蛋白H3E50K重塑染色质以赋予致癌活性并支持上皮间充质转化表型
Kirti Sad,Dorelle V Fawwal,Celina Y Jones et al.
Kirti Sad et al.
Sequencing of human patient tumors has identified recurrent missense mutations in genes encoding core histones. We report that mutations that convert histone H3 amino acid 50 from a glutamate to a lysine (H3E50K) support an oncogenic phenot...
Specific modulation of 28S_Um2402 rRNA 2'- O-ribose methylation as a novel epitranscriptomic marker of ZEB1-induced epithelial-mesenchymal transition in different mammary cell contexts [0.03%]
ZEB1诱导的不同乳腺细胞背景上皮间质转化的新型表转录组学标记28S_Um2402 rRNA 2'-O-岩藻糖基化特异性调节
Chloé Morin,Hermes Paraqindes,Flora Nguyen Van Long et al.
Chloé Morin et al.
The epithelial-mesenchymal transition (EMT) is a dynamic transdifferentiation of epithelial cells into mesenchymal cells. EMT programs exhibit great diversity, based primarily on the distinct impact of molecular activities of the EMT transc...
The Atlas of Protein-Protein Interactions in Cancer (APPIC)-a webtool to visualize and analyze cancer subtypes [0.03%]
癌症蛋白质-蛋白质相互作用图谱(APPIC)-用于可视化和分析癌症亚型的网络工具
Benjamin Ahn,Charissa Chou,Caden Chou et al.
Benjamin Ahn et al.
Cancer is a complex disease with heterogeneous mutational and gene expression patterns. Subgroups of patients who share a phenotype might share a specific genetic architecture including protein-protein interactions (PPIs). We developed the ...
Spatial transcriptomics in breast cancer reveals tumour microenvironment-driven drug responses and clonal therapeutic heterogeneity [0.03%]
空间转录组学揭示了肿瘤微环境驱动的药物反应和治疗异质性克隆
María José Jiménez-Santos,Santiago García-Martín,Marcos Rubio-Fernández et al.
María José Jiménez-Santos et al.
Breast cancer patients are categorized into three subtypes with distinct treatment approaches. Precision oncology has increased patient outcomes by targeting the specific molecular alterations of tumours, yet challenges remain. Treatment fa...
RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models [0.03%]
放射诱变招募与复制叉稳定度无关但与卵巢癌患者衍生移植瘤模型中的PARP抑制剂反应相关
Francien Talens,Vivian Oliviera Nunes Teixeira,Yannick P Kok et al.
Francien Talens et al.
Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been attributed to homologous recombination (HR) defects, other roles of HR factors have also been lin...
Ian R Sturgill,Jesse R Raab,Katherine A Hoadley
Ian R Sturgill
Aberrant expression of the BAP1 (BRCA associated protein 1) tumor suppressor gene is a prominent risk factor for several tumor types and is important in tumor evolution and progression. Here we performed integrated multi-omics analyses usin...
Integration of transcriptional and epigenetic regulation of TFEB reveals its dual functional roles in Pan-cancer [0.03%]
转录和表观遗传对TFEB的整合调节揭示了其在泛癌中的双重功能角色
Jing-Fang Luo,Shijia Wang,Jiajing Fu et al.
Jing-Fang Luo et al.
Transcription factor EB (TFEB) mainly regulates the autophagy-lysosomal pathway, associated with many diseases, including cancer. However, the role of TFEB in pan-cancer has not been investigated systematically. In this study, we comprehens...
Sensitization of melanoma cells to standard chemotherapy: G-quadruplex binders as synergistic agents [0.03%]
G-四链体结合剂作为协同剂增强黑色素瘤细胞对化疗的敏感性
Carolina Persico,Nunzia Iaccarino,Francesca Romano et al.
Carolina Persico et al.
The use of chemotherapeutics has achieved considerable success in cancer therapy; however, their toxicity can severely impact patients' health. In this study, aiming to reduce the doses and potential side effects of traditional chemotherape...
Massively parallel reporter assays identify enhancer elements in oesophageal Adenocarcinoma [0.03%]
高通量报告基因鉴定食管腺癌中的增强子元件
Shen-Hsi Yang,Ibrahim Ahmed,Yaoyong Li et al.
Shen-Hsi Yang et al.
Cancer is a disease underpinned by aberrant gene expression. Enhancers are regulatory elements that play a major role in transcriptional control and changes in active enhancer function are likely critical in the pathogenesis of oesophageal ...