The role of recurrent somatic mutations that alter conserved m6A motifs in human cancer [0.03%]
人类癌症中反复出现的改变m6A保守基序的体细胞突变的作用
Oliver Artz,James R White,Benoit Rousseau et al.
Oliver Artz et al.
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes and plays a key role in cellular growth and development. Global changes in cellular methylated RNA and m6A-mediated transcript regulation significantly im...
Identification of FLYWCH1 as a regulator of platinum-resistance in epithelial ovarian cancer [0.03%]
识别出FLYWCH1作为上皮性卵巢癌铂耐药的调节因子
Tabea L Fullstone,Helene Rohm,Till Kaltofen et al.
Tabea L Fullstone et al.
Platinum-based combination chemotherapy remains the backbone of first-line treatment for patients with advanced epithelial ovarian cancer (EOC). While most patients initially respond well to the treatment, patients with relapse ultimately d...
SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression [0.03%]
SRSF2过表达诱导转录/复制依赖性DNA双链断裂并干扰DNA修复途径以促进肺癌进展
Manal Khalife,Tao Jia,Pierre Caron et al.
Manal Khalife et al.
SRSF2 (serine/arginine-rich splicing factor 2) is a critical regulator of pre-messenger RNA splicing, which also plays noncanonical functions in transcription initiation and elongation. Although elevated levels of SRSF2 are associated with ...
Matrix stiffness modulates androgen response genes and chromatin state in prostate cancer [0.03%]
矩阵硬度调节前列腺癌中的雄激素反应基因和染色质状态
Roosa Kaarijärvi,Heidi Kaljunen,Onni Niemi et al.
Roosa Kaarijärvi et al.
The interplay between the extracellular matrix (ECM) and prostate cancer has been shown to increase ECM stiffness, correlating with more aggressive disease forms. However, the impact of ECM stiffness on the androgen receptor (AR), a key tar...
TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress [0.03%]
TRIP13保护胰腺癌细胞免受内在和治疗诱导的DNA复制压力
Jay R Anand,Gaith N Droby,Sayali Joseph et al.
Jay R Anand et al.
Oncogene activation in normal untransformed cells induces DNA replication stress and creates a dependency on DNA damage response (DDR) mechanisms for cell survival. Different oncogenic stimuli signal via distinct mechanisms in every cancer ...
Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment [0.03%]
利用可替代末端连接的转录调控来预测癌症治疗方法
Roderic Espín,Ferran Medina-Jover,Javier Sigüenza-Andrade et al.
Roderic Espín et al.
Alternative end-joining (alt-EJ) is an error-prone DNA repair pathway that cancer cells deficient in homologous recombination rely on, making them vulnerable to synthetic lethality via inhibition of poly(ADP-ribose) polymerase (PARP). Targe...
Optical genome and epigenome mapping of clear cell renal cell carcinoma [0.03%]
透明细胞肾细胞癌的光学基因组和表观基因组映射
Sapir Margalit,Zuzana Tulpová,Yael Michaeli et al.
Sapir Margalit et al.
Cancer cells display complex genomic aberrations that include large-scale genetic rearrangements and epigenetic modulation that are not easily captured by short-read sequencing. This study presents a novel approach for simultaneous profilin...
The IGF2BP1 oncogene is a druggable m6A-dependent enhancer of YAP1-driven gene expression in ovarian cancer [0.03%]
IGF2BP1癌基因是卵巢癌中YAP1驱动的基因表达的依赖m6A的增强因子，而且可以被药物抑制
Annekatrin Schott,Theresa Simon,Simon Müller et al.
Annekatrin Schott et al.
The Hippo/YAP1 signaling pathway regulates normal development by controlling contact inhibition of growth. In cancer, YAP1 activation is often dysregulated, leading to excessive tumor growth and metastasis. SRC kinase can cross talk to Hipp...
In vivo selection of anti-glioblastoma DNA aptamers in an orthotopic patient-derived xenograft model [0.03%]
在正交患者衍生移植模型中对反胶质母细胞瘤的DNA适体进行体内选择
Caroline D Doherty,Brandon A Wilbanks,Sonia Jain et al.
Caroline D Doherty et al.
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor of adults. Current therapeutic options yield dismal prognoses that have remained essentially unchanged over nearly two decades. Diffuse growth patterns, high...
Therapy enhancing chromosome instability may be advantageous for IDH1 R132H/WT gliomas [0.03%]
增强染色体不稳定性的疗法可能对IDH1 R132H/WT胶质瘤有利
Nikolay V Goncharov,Ivan N Baklanov,Valeriia S Gulaia et al.
Nikolay V Goncharov et al.
Recently revised brain tumor classification suggested a glioma treatment strategy that takes into consideration molecular variants in IDH1 and TP53 marker genes. While pathogenic variants of IDH1 and TP53 can be accompanied by chromosomal i...