Neural interaction explainable AI predicts drug response across cancers [0.03%]
基于神经交互的可解释AI预测肿瘤药物反应
Philipp Keyl,Julius Keyl,Andreas Mock et al.
Philipp Keyl et al.
Personalized treatment selection is crucial for cancer patients due to the high variability in drug response. While actionable mutations can increasingly inform treatment decisions, most therapies still rely on population-based approaches. ...
Analysis of the mRNA modification machinery alterations in breast cancer through the SCAN-B cohort [0.03%]
通过SCAN-B队列分析乳腺癌中mRNA修饰机制的改变
Carlos Peula,Margalida Esteva-Socias,Kanchan Kumari et al.
Carlos Peula et al.
Epitranscriptomic modifications regulate gene expression and have been implicated in cancer, including breast cancer. Using the SCAN-B cohort, we analyzed 49 messenger RNA modification regulators (mRMPs) across breast cancer subtypes. In th...
SETD6 mediates selective interaction and genomic occupancy of BRD4 and MITF in melanoma cells [0.03%]
SETD6介导BRD4和MITF在黑色素瘤细胞中的相互作用及基因组定位
Tzofit Elbaz Biton,Michal Feldman,Tomer Davidy et al.
Tzofit Elbaz Biton et al.
Aberrant transcriptional programs mediate malignant transformation of melanoma, the most aggressive form of skin cancer. The lysine methyltransferase SETD6 has been implicated in regulating transcription, cell adhesion, migration, and other...
m6A modification in R-loop homeostasis: a potential target for cancer therapeutics [0.03%]
R环稳态中的m6A修饰：癌症治疗的潜在靶点
Minh-Anh Vu,Manuela Spagnuolo,Chun-Long Chen
Minh-Anh Vu
R-loops or DNA-RNA hybrids are prominent nucleic acid structures that commonly arise during transcription. These structures play important biological functions, such as regulating gene expression and DNA repair. However, when unresolved by ...
Automated machine learning profiling with MAP-HR for quantifying homologous recombination foci in patient samples [0.03%]
基于MAP-HR的自动机器学习定位量化患者样本同源重组焦点
Tugba Y Ozmen,Matthew J Rames,Gabriel M Zangirolani et al.
Tugba Y Ozmen et al.
Accurate visualization and quantification of homologous recombination (HR)-associated foci in readily available patient samples are critical for identifying patients with HR deficiency (HRD) when they present for care to guide polyADP ribos...
Discovery of epigenetically silenced tumour suppressor genes in aggressive breast cancer through a computational approach [0.03%]
通过计算方法发现三阴性乳腺癌中表观遗传学沉默的抑癌基因
Anne-Laure Vitte,Florent Chuffart,Emmanuelle Jacquet et al.
Anne-Laure Vitte et al.
Breast cancer is characterized by genetic and epigenetic deregulations, leading to aberrant expression of tissue-specific genes that are normally silent in healthy breast tissue. Our previous work identified the embryonic stem cell-specific...
GSK-3484862, a DNMT1 degrader, promotes DNMT3B expression in lung cancer cells [0.03%]
GSK-3484862通过靶向DNMT1蛋白降解促进肺肿瘤细胞中DNMT3B表达
Qin Chen,Swanand Hardikar,Kimie Kondo et al.
Qin Chen et al.
DNA methylation alterations, including hypermethylation and silencing of tumor suppressor genes, contribute to cancer formation and progression. The FDA-approved nucleoside analogs azacytidine and decitabine are effective demethylating agen...
Correction to 'PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery' [0.03%]
"PDXNet门户网站：患者来源的异种移植模型、数据、工作流程和工具发现"的更正
[This corrects the article DOI: 10.1093/nar/zcac014.]. © The Author(s) 2025. Published by Oxford University Press on behalf of NAR Cancer.
Published Erratum
NAR cancer. 2025 May 27;7(2):zcaf019. DOI:10.1093/narcan/zcaf019 2025
Synergistic enhancement of PARP inhibition via small molecule UNI66-mediated suppression of BRD4-dependent transcription of RAD51 and CtIP [0.03%]
小分子UNI66通过抑制BRD4介导的RAD51和CtIP转录增强PARP抑制的协同作用
Enkhzul Amarsanaa,Minwoo Wie,Unbeom Shin et al.
Enkhzul Amarsanaa et al.
Targeted therapy leveraging synthetic lethality in homologous recombination (HR)-defective tumors, particularly in BRCA-mutated tumors through poly(ADP-ribose) polymerase (PARP)-dependent repair inhibition, has shown success. However, the c...
PARP inhibitor response is enhanced in prostate cancer when XRCC1 expression is reduced [0.03%]
XRCC1表达降低可增强前列腺癌的PARP抑制剂治疗效果
Kaveri Goel,Vani Venkatappa,Kimiko L Krieger et al.
Kaveri Goel et al.
Prostate cancer (PCa) is the second most common cancer worldwide and the fifth leading cause of cancer-related deaths among men. The emergence of metastatic castration-resistant prostate cancer (mCRPC) after androgen deprivation therapy (AD...