Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair [0.03%]
靶向抑制雄激素受体可使前列腺癌模型中PARP抑制剂的作用超出了BRCA基因突变和同源重组修复缺陷的范围
Giuditta Illuzzi,Alessandro Galbiati,Anna D Staniszewska et al.
Giuditta Illuzzi et al.
Clinical trials show benefit of the combination of poly(ADP-ribose) polymerase inhibitors (PARPi) with androgen receptor (AR) pathway inhibitors (ARPi) in metastatic, castration-resistant prostate cancer. While benefit was evident in patien...
Co-expression of CD30 and SLFN11 serves as a dual biomarker for the treatment of cutaneous T-cell lymphoma [0.03%]
CD30和SLFN11共表达可作为治疗皮肤T细胞淋巴瘤的双生物标志物
Takatoshi Shimauchi,Junko Murai,Manami Iwasaki et al.
Takatoshi Shimauchi et al.
Advanced-stage cutaneous T-cell lymphoma (CTCL) is treated with diverse modalities, including DNA-damaging agents, anti-CD30 antibody-drug conjugates, and histone deacetylase (HDAC) inhibitors. Schlafen 11 (SLFN11) has emerged as a key dete...
Reference-free RNA profiling predicts triple negative breast cancer chemoresistance to neoadjuvant treatment [0.03%]
无参考RNA谱分析预测新辅助治疗对三阴性乳腺癌的化学耐药性
Nouritza Torossian,Marc Gabriel,Panagiotis Papoutsoglou et al.
Nouritza Torossian et al.
Triple negative breast cancer (TNBC) is the most aggressive breast cancer (BC) and often affects young women. TNBCs are highly heterogeneous and do not benefit from personalized medicine at localized stages. Most TNBC patients undergo neoad...
DNA repair helicases: from mechanistic understanding to therapeutic implications [0.03%]
DNA修复解旋酶：从机制理解到治疗意义
Vijay Menon,Susan E Gueble
Vijay Menon
The maintenance of genomic integrity is paramount for normal cell physiology and survival as well as avoidance of carcinogenesis. Cellular DNA is periodically subjected to a myriad of exogenous and endogenous threats and requires constant m...
ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer [0.03%]
ABL1介导的SYCP2酪氨酸磷酸化促进卵巢癌中转录偶联同源重组及铂类耐药
Boya Gao,Xudong Wang,Melissa Long et al.
Boya Gao et al.
Treatment of patients with platinum-resistant ovarian cancer is a major clinical challenge. We found that high expression of a meiotic protein, Synaptonemal Complex Protein 2 (SYCP2), is associated with platinum resistance and tyrosine kina...
The aflatoxin B1-induced formamidopyrimidine adduct is repaired by transcription-coupled nucleotide excision repair in human cells [0.03%]
黄曲霉毒素B1诱导的形式氨基嘧啶烷基化碱基由转录耦联的核苷酸切除修复系统在人类细胞中进行修复
Daniel J Laverty,Rachana Tomar,Sophie Erlich et al.
Daniel J Laverty et al.
The mycotoxin, aflatoxin B1 (AFB1), is a potent mutagen that contaminates agricultural food supplies. After ingestion, AFB1 is oxidized into a reactive electrophile that alkylates DNA, forming bulky lesions such as the genotoxic formamidopy...
Inherent single-cell heterogeneity of the transcriptional response to hypoxia in cancer cells [0.03%]
癌细胞缺氧转录反应的固有单细胞异质性
Małgorzata Wilk,Thomas Knöpfel,Stana M Burger et al.
Małgorzata Wilk et al.
Hypoxia-inducible factor (HIF) is a master regulator of cancer cell adaptation to tumor hypoxia and is involved in cancer progression. Single-cell (sc) differences in the HIF response allow for tumor evolution and cause therapy resistance. ...
Anti-tumorigenic properties by trichothiodystrophy mutations in melanocytic cells [0.03%]
黑素细胞中由细丝硫缺陷症突变引起的抗肿瘤特性
Rupesh Paudel,Lena F Sorger,Anita Hufnagel et al.
Rupesh Paudel et al.
Germline mutations in the DNA repair helicase XPD can cause the diseases xeroderma pigmentosum (XP) and trichothiodystrophy (TTD). XP patients bear an increased risk of skin cancer including melanoma. This is not observed for TTD patients d...
Loss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance [0.03%]
核糖体蛋白uL14丧失使肿瘤逃逸T细胞免疫监视
Anna Dopler,Edwin S Kyei-Baffour,Mandy Kerkhoff et al.
Anna Dopler et al.
The presentation of peptides on HLA molecules is essential to CD8+ T cell responses. Here, we show that loss of uL14 significantly downregulates the expression of antigen processing and presentation (APP) components in melanoma cell lines. ...
Regulation of angiogenesis and cancer cell proliferation by human vault RNA1-2 [0.03%]
人类vault小核仁rna1-2调控血管生成和癌细胞增殖
Stefano Gallo,Anastasiia Suspitsyna,Daniel Sanchez-Taltavull et al.
Stefano Gallo et al.
Noncoding RNAs play pivotal roles in tumorigenesis and cancer progression. Recent evidence has identified vault RNAs (vtRNAs) as critical regulators of cellular homeostasis. The human genome encodes four vtRNA paralogs, which are differenti...