Pan-cancer proteogenomic analysis reveals long and circular noncoding RNAs encoding peptides [0.03%]
泛癌症蛋白质基因组分析揭示了长链和环状非编码RNA编码的肽类
Ghofran Othoum,Emily Coonrod,Sidi Zhao et al.
Ghofran Othoum et al.
Recent studies show that annotated long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) encode for stable, functional peptides that contribute to human development and disease. To systematically discover lncRNAs and circRNAs encoding ...
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells [0.03%]
BRCA2缺陷细胞中XRCC1促进复制重启，新生叉降解和致突变DNA修复
Bradley J Eckelmann,Albino Bacolla,Haibo Wang et al.
Bradley J Eckelmann et al.
Homologous recombination/end joining (HR/HEJ)-deficient cancers with BRCA mutations utilize alternative DNA double-strand break repair pathways, particularly alternative non-homologous end joining or microhomology-mediated end joining (alt-...
Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma [0.03%]
CXCR1/CXCR2生物学在原发性PTEN缺陷前列腺癌复发和放疗抵抗中的临床和功能特征分析
Chris W D Armstrong,Jonathan A Coulter,Chee Wee Ong et al.
Chris W D Armstrong et al.
Functional impairment of the tumour suppressor PTEN is common in primary prostate cancer and has been linked to relapse post-radiotherapy (post-RT). Pre-clinical modelling supports elevated CXC chemokine signalling as a critical mediator of...
Characterizing and classifying neuroendocrine neoplasms through microRNA sequencing and data mining [0.03%]
通过microRNA测序和数据挖掘来特征化和分类神经内分泌肿瘤
Jina Nanayakkara,Kathrin Tyryshkin,Xiaojing Yang et al.
Jina Nanayakkara et al.
Neuroendocrine neoplasms (NENs) are clinically diverse and incompletely characterized cancers that are challenging to classify. MicroRNAs (miRNAs) are small regulatory RNAs that can be used to classify cancers. Recently, a morphology-based ...
Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells [0.03%]
蛋白质组动力学分析鉴定出SDE2和低氧在前列腺癌细胞的DNA损伤反应中的功能作用
Ang Luo,Yao Gong,Hyungjin Kim et al.
Ang Luo et al.
Mechanistic understanding of hypoxia-responsive signaling pathways provides important insights into oxygen- and metabolism-dependent cellular phenotypes in diseases. Using SILAC-based quantitative proteomics, we provided a quantitative map ...
Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses [0.03%]
结构特异性内切酶EEPD1和Metnase在复制压力反应中的不同作用
Neelam Sharma,Michael C Speed,Christopher P Allen et al.
Neelam Sharma et al.
Accurate DNA replication and segregation are critical for maintaining genome integrity and suppressing cancer. Metnase and EEPD1 are DNA damage response (DDR) proteins frequently dysregulated in cancer and implicated in cancer etiology and ...
KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells [0.03%]
ZFP568的KRAB结构域干扰癌症细胞中的TRIM28介导的异常相互作用
Janani Kumar,Gundeep Kaur,Ren Ren et al.
Janani Kumar et al.
Interactions of KRAB (Krüppel-associated box)-associated protein KAP1 [also known as TRIM28 (tripartite motif containing protein 28)] with DNA-binding KRAB zinc finger (KRAB-ZF) proteins silence many transposable elements during embryogene...
Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling [0.03%]
内在的ATR信号塑造了DNA末端切除并抑制了有毒的DNA-PKcs信号
Diego Dibitetto,Jennie R Sims,Carolline F R Ascenção et al.
Diego Dibitetto et al.
Most cancer cells experience oncogene-induced replication stress and, as a result, exhibit high intrinsic activation of the ATR kinase. Although cancer cells often become more dependent on ATR for survival, the precise mechanism by which AT...