Reversing uL3-mediated chemoresistance through synergistic combination of 5-FU and G-quadruplex ligands [0.03%]
利用5-FU和G-四链体配体协同逆转uL3介导的化学抗性
Anna Di Porzio,Annalisa Pecoraro,Camilla Danisi et al.
Anna Di Porzio et al.
Chemoresistance represents a significant challenge in the chemotherapy of colorectal cancer (CRC), limiting the effectiveness. In this regard, gene expression heterogeneity plays a critical role, influencing cancer cell adaptability and sur...
DVFGCDR: a dual-view fusion graph neural network for cancer drug response prediction [0.03%]
基于双视图融合图神经网络的癌症药物反应预测模型
Weihong Huang,Shengwei Qin,Haohao Li et al.
Weihong Huang et al.
The prediction of cancer drug responses (CDRs) holds considerable relevance for the guidance of patient-specific clinical treatments. However, the inherent cellular heterogeneity among cancers introduces substantial challenges to such predi...
Thomas L Ekstrom,Steven A Johnsen
Thomas L Ekstrom
This short review highlights recent findings related to transcription factor-mediated RNA polymerase II (Pol II) pause release at enhancers and its role in regulating cell identity. We discuss how the transcriptional state of Pol II, either...
Polymerase θ-what does it see, and why does it matter for cancer therapy? [0.03%]
聚合酶θ的视界及其在癌症治疗中的意义
Dale A Ramsden,Gaorav P Gupta
Dale A Ramsden
Polymerase theta (Pol θ) is a DNA repair factor that has drawn much recent interest as a target for cancer therapy, since its inhibition is well-tolerated in most cells but is lethal in cancers deficient in breast cancer-associated (BRCA) ...
Exploiting nanopore sequencing advances for tRNA sequencing of human cancer models [0.03%]
利用纳米孔测序技术的进步对人类癌症模型中的tRNA进行测序
Adva Kochavi,Arno Velds,Maya Suzuki et al.
Adva Kochavi et al.
Transfer RNAs (tRNAs) are essential regulators of protein synthesis, and dysregulation of their abundance and modification status is involved in many human diseases including cancer. Despite the rapid development of novel tRNA sequencing ap...
Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors [0.03%]
用于拓扑蛋白BP1生物分子凝聚体抑制剂的光遗传学筛选技术揭露药物新机转
Laura Morano,Nadia Vie,Adam Aissanou et al.
Laura Morano et al.
Human topoisomerase IIβ binding protein 1 (TopBP1) is a scaffold protein involved in DNA replication initiation, DNA repair, transcription regulation, and checkpoint activation. TopBP1 forms nuclear condensates that act as a molecular swit...
Targeting DNA repair mechanisms in cancer therapy: the role of small molecule DNA repair inhibitors [0.03%]
靶向DNA修复机制的癌症治疗：小分子DNA修复抑制剂的作用
Seula Jeong,Yuheon Chung,Soomin Heo et al.
Seula Jeong et al.
Genomic instability and the accumulation of DNA damage are hallmarks of cancer, often resulting from defects in DNA repair pathways. While normal cells rely on highly coordinated DNA damage response (DDR) mechanisms to maintain genomic inte...
Brain tumor classification from FFPE samples using nanopore methylation sequencing [0.03%]
基于纳米孔甲基化测序的福马林固定石蜡包埋样本脑肿瘤分类
Galina Feinberg-Gorenshtein,Assaf Grunwald,Carlo Vermeulen et al.
Galina Feinberg-Gorenshtein et al.
Oxford Nanopore Technology (ONT)-based methylation sequencing is emerging as a powerful approach for the rapid and accurate classification of brain tumors, an essential component of precision oncology. However, its broader clinical adoption...
THRESHOLD: a comprehensive transcriptomic analysis tool for evaluating gene saturation and impact in disease progression [0.03%]
阈值：一种全面的转录组分析工具 用于评估基因饱和度和疾病进展中的基因影响
Finán Gammell,Jennifer Li,Christopher Elco et al.
Finán Gammell et al.
Gene expression studies are fundamental in molecular biology, offering insights into development, disease progression, and therapeutic targets. To address the need for precise analysis of large datasets, we developed THRESHOLD, a novel tool...
G-quadruplex ligand RHPS4 compromises cellular radioresistance by inhibiting the mitochondrial adaptive response induced by ionizing irradiation [0.03%]
G四链体配体RHPS4通过抑制离子辐射诱导的线粒体适应性反应来破坏细胞放射耐受性
Sabine Tricot,Capucine Siberchicot,Isaline Bontemps et al.
Sabine Tricot et al.
A major challenge in radiotherapy is to enhance tumour cell sensitivity to radiation while minimizing damage to healthy tissues. Enhancing the effectiveness of radiotherapy can be achieved by combining irradiation with small radiosensitizin...