Integrated enhancer regulatory network by enhancer-promoter looping in gastric cancer [0.03%]
胃癌中通过增强子-启动子环形成调控网络的整合
Tianhui Zhu,Atsushi Okabe,Genki Usui et al.
Tianhui Zhu et al.
Enhancer cis-regulatory elements play critical roles in gene regulation at many stages of cell growth. Enhancers in cancer cells also regulate the transcription of oncogenes. In this study, we performed a comprehensive analysis of long-rang...
Metabolism-dependent secondary effect of anti-MAPK cancer therapy on DNA repair [0.03%]
抗MAPK癌症疗法对DNA修复的代谢依赖性二级效应
Fabien Aubé,Nicolas Fontrodona,Laura Guiguettaz et al.
Fabien Aubé et al.
Amino acid bioavailability impacts mRNA translation in a codon-dependent manner. Here, we report that the anti-cancer MAPK inhibitors (MAPKi) decrease the intracellular concentration of aspartate and glutamate in melanoma cells. This coinci...
HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression [0.03%]
HDAC10抑制通过上调SPARC表达来抑制黑色素瘤细胞增殖和BRAF抑制耐药性
Hongbo Ling,Yixuan Li,Changmin Peng et al.
Hongbo Ling et al.
Secreted protein acidic and rich in cysteine (SPARC), a conserved secreted glycoprotein, plays crucial roles in regulating various biological processes. SPARC is highly expressed and has profound implications in several cancer types, includ...
The impact of ribosome biogenesis in cancer: from proliferation to metastasis [0.03%]
核糖体生物发生对癌症的影响：从增殖到转移
Sseu-Pei Hwang,Catherine Denicourt
Sseu-Pei Hwang
The dysregulation of ribosome biogenesis is a hallmark of cancer, facilitating the adaptation to altered translational demands essential for various aspects of tumor progression. This review explores the intricate interplay between ribosome...
Annagiulia Ciocia,Neus Mestre-Farràs,Ignacio Vicent-Nacht et al.
Annagiulia Ciocia et al.
RNA-binding proteins (RBPs) have garnered significant attention in the field of cancer due to their ability to modulate diverse tumor traits. Once considered untargetable, RBPs have sparked renewed interest in drug development, particularly...
The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunities [0.03%]
DNA损伤反应(DDR)在子宫内膜癌中的作用定义了不同的疾病亚型并揭示了治疗机会
Xingyuan Zhang,Sayali Joseph,Di Wu et al.
Xingyuan Zhang et al.
Genome maintenance is an enabling characteristic that allows neoplastic cells to tolerate the inherent stresses of tumorigenesis and evade therapy-induced genotoxicity. Neoplastic cells also deploy many mis-expressed germ cell proteins term...
Nicholas Manguso,Minhyung Kim,Neeraj Joshi et al.
Nicholas Manguso et al.
With its ligand estrogen, the estrogen receptor (ER) initiates a global transcriptional program, promoting cell growth. This process involves topoisomerase 2 (TOP2), a key protein in resolving topological issues during transcription by clea...
XPA tumor variant leads to defects in NER that sensitize cells to cisplatin [0.03%]
XPA肿瘤突变体导致NER缺陷并使细胞对顺铂敏感
Alexandra M Blee,Kaitlyn S Gallagher,Hyun-Suk Kim et al.
Alexandra M Blee et al.
Nucleotide excision repair (NER) reduces efficacy of treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss of the NER genes Excision Repair Cross Comple...
Singleton mutations in large-scale cancer genome studies: uncovering the tail of cancer genome [0.03%]
大规模癌症基因组研究中的单例突变：揭示癌症基因组的尾部特征
Sanket Desai,Suhail Ahmad,Bhargavi Bawaskar et al.
Sanket Desai et al.
Singleton or low-frequency driver mutations are challenging to identify. We present a domain driver mutation estimator (DOME) to identify rare candidate driver mutations. DOME analyzes positions analogous to known statistical hotspots and r...
The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues [0.03%]
tRNA修饰对癌症中蛋白质翻译的影响：识别新型治疗途径
Ana M Añazco-Guenkova,Borja Miguel-López,Óscar Monteagudo-García et al.
Ana M Añazco-Guenkova et al.
Recent advancements have illuminated the critical role of RNA modifications in post-transcriptional regulation, shaping the landscape of gene expression. This review explores how tRNA modifications emerge as critical players, fine-tuning fu...