Spinal high-grade astrocytoma with piloid features arising in a patient with molecularly confirmed cerebellar pilocytic astrocytoma [0.03%]
伴有小脑毛细胞星形细胞瘤分子特征的脊髓 piloid 表型的高级别星形细胞瘤病例报告
Xiaoci Rong,Nan Chen,Yanghao Hou et al.
Xiaoci Rong et al.
Pilocytic astrocytoma (PA) is a benign tumor with a low risk of high-grade transformation. High-grade astrocytoma with piloid features (HGAP) is a recently recognized tumor entity that may arise de novo or from low-grade gliomas. Here, we r...
Patient preferences for incidental findings in a genomic trial: Insights from the Copenhagen glioblastoma cohort [0.03%]
基因组试验中患者对意外发现的偏好：哥本哈根胶质母细胞瘤队列中的启示
Anders Overby Sjøstrøm,Maria Camilla Mathiasen,Ulrik Lassen et al.
Anders Overby Sjøstrøm et al.
Glioblastoma (GBM) patients often face cognitive impairment, which may limit their capacity to comprehend complex trial information, particularly regarding genomic analyses and incidental findings. We analyzed consent forms from a genomic s...
Clinical characteristics and outcomes of adult IDH-mutant brainstem gliomas: Institutional case series and systematic review [0.03%]
IDH突变脑干胶质瘤的临床特征和预后：机构病例系列及系统综述
Maged T Ghoche,Kenji Miki,Fanen Yuan et al.
Maged T Ghoche et al.
Background: Adult IDH-mutant brainstem gliomas (BSGs) are rare and appear molecularly distinct from H3K27-altered diffuse midline gliomas. We aimed to provide a comprehensive characterization by integrating an institution...
Preoperative tumor and edema volumes as predictors of ischemia and morbidity after intracranial meningioma surgery [0.03%]
术前肿瘤和水肿体积对颅内脑膜瘤术后缺血及后遗症的预测作用
Sahin Hanalioglu,Efecan Cekic,Emin Tabipoglu et al.
Sahin Hanalioglu et al.
Background: Ischemic complications remain a significant risk indicator of morbidity after meningioma surgery. While tumor size and extent of resection (EOR) are recognized risk factors, the prognostic impact of peritumora...
A new hope: Clinical advances in targeted therapies for pediatric diffuse midline glioma [0.03%]
新希望：儿童弥漫性中线胶质瘤靶向治疗临床进展
Joshua Zhu,Maria Tsoli,Jean Bertoldo et al.
Joshua Zhu et al.
Diffuse midline glioma (DMG) is an aggressive pediatric brain tumor with a 1%-2% overall survival, largely due to the ineffectiveness of conventional treatments such as chemotherapy and radiotherapy, as well as the inoperability of the tumo...
Sébastien Perreault,François Doz
Sébastien Perreault
The NTRK1, NTRK2, and NTRK3 genes encode the TRKA, TRKB, and TRKC receptors, critical for nervous system development. Gene fusions involving neurotrophic tyrosine receptor kinase (NTRK) are found in various cancers. In the pediatric populat...
MEK inhibitors for neurofibromatosis type 1-associated central and peripheral nervous system tumors [0.03%]
用于治疗神经纤维瘤病Ⅰ型相关中枢和外周神经系统肿瘤的MEK抑制剂
Chelsea Kotch,Peter de Blank,Jason Fangusaro et al.
Chelsea Kotch et al.
Neurofibromatosis type 1 (NF1)-associated tumors typically develop in the setting of biallelic inactivation of the NF1 gene and resultant overactivation of the Ras/mitogen-activated protein kinase signaling pathway. Mitogen-activated protei...
From blunt tools to bullseyes: The impact of targeted therapy in pediatric neuro-oncology [0.03%]
从粗略工具到精准武器：靶向疗法在儿童神经肿瘤学中的影响
Julie Bennett,Eric Bouffet
Julie Bennett
Targeted therapies in adolescent and young adult patients with central nervous system tumors [0.03%]
青少年及年轻成人中枢神经系统肿瘤的靶向治疗
Anna Mullins,Julie Bennett,Kee Kiat Yeo et al.
Anna Mullins et al.
Adolescents and young adults (AYA: ages 15-39 years) are a unique population at risk of both pediatric-type and adult-type central nervous system (CNS) tumors. Targeted therapies are now available for a growing subset of CNS tumors represen...
Anfal Jasem M Alshammari,Darren Hargrave,Anirban Das
Anfal Jasem M Alshammari
Unresectable pediatric low-grade glioma is a chronic disease that can cause significant morbidity in young patients. Historically, treatment has mainly involved chemotherapy, with many patients needing multiple lines of treatment for a recu...