Brain metastasis patient-derived xenograft models to characterize the contribution of brain microenvironment to metastatic outgrowth [0.03%]
脑转移患者来源的异种移植模型用于表征脑微环境对转移生长的贡献
Maria Cecília Oliveira-Nunes,Weili Ma,Chenyu Mao et al.
Maria Cecília Oliveira-Nunes et al.
Background: Brain metastasis is the most ominous form of cancer relapse. There is urgent need to develop preclinical mouse models to study brain metastasis and new therapeutic strategies. Patient derived xenograft (PDX) m...
Distribution and prognostic significance of myelotoxicity in newly diagnosed glioblastoma in a real-life cohort: Time to treat more aggressively? [0.03%]
真实世界队列中初治胶质母细胞瘤患者髓毒性分布及预后意义：是时候更积极地治疗了吗？
Christoph Oster,Pia Reineck,Teresa Schmidt et al.
Christoph Oster et al.
Background: Glioblastoma represents one of the most aggressive and fatal primary brain tumors in adults. Chemotherapeutic agents, while integral to management, frequently induce varying levels of myelotoxicity. The aim is...
A novel vascular model yields increased MR perfusion metrics compared to conventional dynamic susceptibility contrast algorithms in untreated glioblastoma [0.03%]
一种新型血管模型与动态对比增强MRI相比可增加新诊断胶质母细胞瘤的灌注参数
Jonas Reis,Robert Stahl,Katharina J Müller et al.
Jonas Reis et al.
Background: Malignant gliomas are heterogeneous brain tumors with extensive neovascularization. Conventional gradient-echo dynamic susceptibility contrast (GRE-DSC) perfusion MRI may underestimate microvascular alteration...
Long-term outcomes of active surveillance after DOTATATE PET/MRI-confirmed gross total resection in WHO grade 2 meningioma [0.03%]
DOTATATE PET/MRI证实的幕上完全切除的世界卫生组织II级脑膜瘤的主动监测的长期结果
Jana Ivanidze,Kellen Vo Vu,Umberto Tosi et al.
Jana Ivanidze et al.
Background: Somatostatin receptor 2 (SSTR2), a highly sensitive and specific meningioma biomarker, can be imaged with [68Ga]-DOTATATE PET, improving diagnosis and treatment. The role of postoperative radiotherapy (RT) for...
Comparing the performance of dynamic susceptibility contrast and arterial spin labeling for detecting residual and recurrent glioblastoma with deep learning and multishell diffusion MRI [0.03%]
基于深度学习和多壳弥散MRI对比动态磁敏感和动脉自旋标记检测胶质母细胞瘤残留和复发的效能研究
Louis Gagnon,Diviya Gupta,George Mastorakos et al.
Louis Gagnon et al.
Background: Differentiating recurrent tumor from post-treatment changes remains a major challenge in glioblastoma (GBM) patients. In this work, we compared the performance of 2 different MR perfusion techniques, dynamic s...
Combined inhibition of lysine-specific demethylase 1 and kinase signaling as a preclinical treatment strategy in glioblastoma [0.03%]
组蛋白去甲基化酶KDM1和激酶信号传导联合抑制作为胶质母细胞瘤的临床前治疗策略
Lea M Stitzlein,Deokhwa Nam,Faith A Hernandez et al.
Lea M Stitzlein et al.
Background: Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma, contributing to tumor growth and treatment resistance. LSD1 inhibitors have shown preclinical promise but have had limited clinical develo...
Unsupervised learning of metabolic fingerprints from 3D magnetic resonance spectroscopic imaging enables glioma subtype classification [0.03%]
无监督学习从三维磁共振波谱成像中提取代谢特征以分类胶质瘤亚型
Gulnur S Ungan,Paul J Weiser,Jorg Dietrich et al.
Gulnur S Ungan et al.
Background: Accurate classification of glioma subtypes is essential for personalized treatment, yet current diagnostic approaches rely on invasive procedures to determine molecular profiles. This study aims to enhance non...
Impact of systemic therapy after stereotactic radiosurgery in patients with limited brain-only metastasis [0.03%]
立体定向放射外科手术后对局限性脑转移患者全身治疗的影响
Jamiluddin J Qazi,Amanda E D Van Swearingen,David J Carpenter et al.
Jamiluddin J Qazi et al.
Background: The impact of systemic therapy (ST) on outcomes for patients with brain-only metastases (BrM) in the absence of extracranial disease (ECD) is not well established. We compared outcomes between patients with Br...
Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation [0.03%]
头对头的临床前治疗设计优先考虑神经纤维瘤病Ⅰ型视神经胶质瘤的临床转化疗法
Talia Eligator,Jit Chatterjee,Shintaro Yamada et al.
Talia Eligator et al.
Background: Authenticated preclinical brain tumor models provide unprecedented opportunities to evaluate next-generation treatments. However, some therapies with robust anti-tumor activity in mice fail in human trials, hi...
Relation between tumor treating fields usage rate ≥75% for the first 3 months and progression-free survival in patients with newly diagnosed WHO grade 4 gliomas [0.03%]
新诊断的WHO IV级胶质瘤患者前3个月肿瘤治疗场使用率≥75%与无进展生存的关系
Shoichi Deguchi,Masashi Kinoshita,Fumiharu Ohka et al.
Shoichi Deguchi et al.
Background: Tumor treating fields (TTFields) therapy is an important treatment for glioblastoma. However, there have been few reports showing the effectiveness thereof in clinical settings worldwide. The aim of this study...