Age-dependent glioma progression and functional decline in a syngeneic murine model: Host vulnerabilities and opportunities for targeted intervention [0.03%]
年龄依赖性胶质瘤小鼠模型的肿瘤进展和功能障碍：宿主易感性和靶向干预的机会
Heloise Leblanc,Michelle Buzharsky,Xaralabos Varelas et al.
Heloise Leblanc et al.
Background: GBM disproportionately affects older adults, who experience worse survival outcomes and reduced tolerance to aggressive therapies. Despite this, most preclinical GBM studies rely on young animal models, limiti...
Limited evidence of pseudoprogression following immune checkpoint inhibitor (ICI) therapy in glioblastoma [0.03%]
免疫检查点抑制剂治疗后胶质母细胞瘤假性进展的证据有限
John Y Rhee,Juan Pablo Ospina Botero,Thomas Nelson et al.
John Y Rhee et al.
"Pseudoprogression" following immune checkpoint inhibitors (ICI) in glioblastoma is often considered in case of radiographic progression. To better characterize the frequency of this phenomenon in glioblastoma, we reviewed the imaging respo...
Fusion transcriptome landscape in glioblastoma: Incidence and therapeutic implications [0.03%]
胶质母细胞瘤中的融合转录组景观：发生率及治疗意义
Sonikpreet Aulakh,Joanne Xiu,Shawn Kothari et al.
Sonikpreet Aulakh et al.
Background: Glioblastoma (GBM) lacks effective therapies for recurrent disease. Unlike cancers with successful fusion-targeted treatments (eg BCR-ABL1 in CML), the incidence and therapeutic potential of gene fusions in GB...
IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms [0.03%]
IGF2通过一组肿瘤细胞内在和外在的机制支持胶质母细胞瘤的生长和免疫逃逸
Kyle M Heemskerk,Samir Assaf,Xiaoguang Hao et al.
Kyle M Heemskerk et al.
Abstract: BackgroundGIntratumoral and intertumoral heterogeneity combined with immunosuppressive tumor microenvironments (TME) contribute to the poor outcomes associated with glioblastoma (GBM). Well-characterized immunoc...
Impact of extent of surgical resection on survival in World Health Organization grade 4 gliomas: A molecular subtype-based analysis [0.03%]
基于分子亚型的分析在世卫组织分级4级胶质瘤中手术切除范围对生存率的影响
Ziming Hou,Wenhao Zhang,Zeya Yan et al.
Ziming Hou et al.
Background: Extensive surgical resection is associated with longer survival in patients with glioma; however, the combined impact of surgical extent and molecular pathology on prognosis remains unclear. In this study, we ...
Desmoplastic infantile ganglioglioma/astrocytoma: Expanding the molecular and morphological spectrum with a novel BRAF fusion [0.03%]
婴儿毛玻璃样胶质瘤/星形细胞瘤的分子及形态谱系的新认识——带有新型BRAF融合基因的病例报告
Ibrahim Kulac,Cisel Aydin Mericoz,Berrin Babaoglu et al.
Ibrahim Kulac et al.
Background: Desmoplastic infantile ganglioglioma/astrocytoma (DIG/DIA) is a rare, low-grade tumor of infants. They are usually composed of a mixed astrocytic and neuronal component with desmoplastic stroma and embryonal-l...
Improved target volume delineation for stereotactic radiosurgery in brain metastases using post-contrast 3D T1 TSE black-blood MRI [0.03%]
使用增强后三维T1-TSE黑血MRI改善脑转移瘤立体定向放射外科手术的目标体积划分
Zhao Hui Chen Zhou,Rafael D Ambrosi,Amaya Hilario et al.
Zhao Hui Chen Zhou et al.
Background: Accurate delineation of brain metastases is essential for the success of stereotactic radiosurgery (SRS). This study aimed to compare the morphological and volumetric characteristics of brain metastases using ...
Impact of proton vs. photon radiotherapy on overall survival in the management of spinal chondrosarcoma and mortality risk prediction: A nationwide analysis [0.03%]
质子治疗和光子治疗对脊柱软骨肉瘤管理的总生存率的影响及死亡风险预测：全国范围内的分析
Abdul Karim Ghaith,Xinlan Yang,Taha Khalilullah et al.
Abdul Karim Ghaith et al.
Background: Spinal chondrosarcomas are rare, aggressive bone tumors with limited data on optimal radiotherapy strategies, particularly regarding the comparison between proton and photon therapies. This study aims to evalu...
Preclinical assessment of checkpoint blockade combined with DNA methyltransferase inhibition in high-risk pediatric brain tumors reveals limited therapeutic synergy [0.03%]
初步评估检点阻断与DNA甲基转移酶抑制在高危儿童脑肿瘤中的治疗作用并发现其协同作用有限
Deepak Kumar Mishra,Shelli M Morris,Dean Popovski et al.
Deepak Kumar Mishra et al.
Abstract: BackgroundDespite intensive therapies, outcomes for high-risk pediatric brain tumors (PBTs) remain dismal, prompting the search for novel treatments. DNA methyltransferase inhibitors (DNMTi) have been shown to p...
Patient-derived organoids and neurospheres recapitulate salient features of primary tumor heterogeneity [0.03%]
患者衍生器官和神经球体概括了原发肿瘤异质性的显著特征
Zachery Moore,Claire Storey,Daniel V Brown et al.
Zachery Moore et al.
Background: The intra- and inter-tumoral heterogeneity of glioblastoma (GBM) represents a significant therapeutic challenge and barrier to the generation of reliable and accurate models for in vitro studies. Three-dimensi...