On the value of microsurgical resection compared to biopsy in elderly glioblastoma patients: A retrospective multicenter analysis and scoring system proposal [0.03%]
关于老年胶质母细胞瘤患者显微外科切除与活检价值的回顾性多中心分析及评分系统建议
Johannes P Pöppe,Melanie Buchta,Matthias Demetz et al.
Johannes P Pöppe et al.
Background: Benefits of tumor resection in elderly glioblastoma multiforme (GBM) patients within the framework of multimodal treatment remains a matter of debate. This retrospective, multicenter analysis aims at the ident...
Pharmacokinetic-pharmacodynamic-efficacy modeling of the MDM2 inhibitor brigimadlin in glioblastoma patient-derived xenografts [0.03%]
MDM2抑制剂brigimadlin在胶质母细胞瘤患者来源异种移植瘤中的药代-药效学效应建模研究
Rachael A Vaubel,Wenjuan Zhang,Nishika Karbhari et al.
Rachael A Vaubel et al.
Background: Murine double minute 2 (MDM2) inhibitors reactivate wild-type p53 and are a promising therapy for glioblastoma, IDH-wildtype (GBM). Brigimadlin is a highly potent MDM2 inhibitor being tested in a phase 0/1 cli...
Outcomes of patients with melanoma brain metastases treated with ipilimumab and nivolumab with or without upfront comprehensive stereotactic radiosurgery [0.03%]
伊匹单抗和尼伏单抗联合或不联合立体定向放射手术治疗黑色素瘤脑转移患者的疗效分析
Troy J Kleber,Denái R Milton,Subhiksha Srinivasan et al.
Troy J Kleber et al.
Background: The efficacy of ipilimumab and nivolumab (ipi/nivo) for melanoma brain metastases (MBMs) has been previously reported, leading to uncertainty regarding the optimal role of comprehensive stereotactic radiosurge...
The impact of postoperative ischemic changes on survival outcomes in IDH-wildtype glioblastoma [0.03%]
IDH野生型胶质母细胞瘤术后缺血改变对生存结局的影响
Neslihan Nisa Gecici,Ahmed Habib,Walaa Hamza et al.
Neslihan Nisa Gecici et al.
Abstract: BackgroundGlioblastoma (GBM) is an aggressive brain tumor. The authors of this study wanted to find out whether areas of reduced blood flow, called ischemia, that appear after surgery affect how long people live...
Metabolomic profiling and stable isotope tracing of human schwannomas: A novel perspective on tumor biology and radiation response [0.03%]
人状瘤的代谢组谱型和稳定同位素示踪：关于肿瘤生物学和放射反应的新视角
Mark C Dougherty,Hashim S Syed,Linjing Xu et al.
Mark C Dougherty et al.
Background: Although schwannomas are common and benign, their growth patterns are often hard to predict. Currently, surgery and radiotherapy are the only standard treatments. Since metabolites are the end products of gene...
Increased immunogenicity of hypermutated SB28 syngeneic glioblastoma is partially mediated by alterations in tumor chemokine expression [0.03%]
超突变的同基因胶质母细胞瘤SB28免疫原性增加部分是通过肿瘤化学因子表达改变介导的
Kevin Thomas Breen,Tuesday Haynes,Matthew Bryce Watowich et al.
Kevin Thomas Breen et al.
Background: Glioblastoma (GBM) prognosis remains poor, and although immune checkpoint inhibitors (ICI) have transformed the treatment of many tumors, they are ineffective in GBM. However, response to ICIs occurs in high-t...
Matthew R Sarkisian,Loic P Deleyrolle,Joshua J Breunig
Matthew R Sarkisian
While many postmitotic cells in the body harbor cilia, certain aggressive cancers such as glioblastoma (GBM) display low frequencies of cells harboring a primary cilium. Ciliated GBM cells that plan to multiply have to disassemble their cil...
T-cell receptor sequencing for detection of Epstein-Barr and cytomegalovirus-specific immune responses in glioma patients: An exploratory study [0.03%]
胶质瘤患者T细胞受体测序检测EB病毒和巨细胞病毒感染特异性免疫反应的探索性研究
Anna E Coghill,Nathan Van Bibber,Sean Yoder et al.
Anna E Coghill et al.
Background: Specific herpesviruses have been implicated in glioma development. We undertook a pilot study to examine whether herpesviruses-specific human T-cell receptor (TCR) sequences in patient blood samples associate ...
Seizure outcomes as an understudied metric in glioma clinical trials: A review of the ClinicalTrials.gov database [0.03%]
胶质瘤临床试验中癫痫发作结果这一被忽视的评价指标：来自ClinicalTrials.gov数据库的证据
Hannah Haile,Nathan A Shlobin,Arjun R Adapa et al.
Hannah Haile et al.
Abstract: BackgroundSeizures are a common and disabling symptom of adult-type diffuse gliomas, affecting quality of life and potentially influencing tumor progression. Despite their clinical significance, seizure outcomes...
A case of radiation treatment effect mimicking viable, recurrent meningioma on DOTATATE PET imaging [0.03%]
一项放射治疗反应模仿DOTATATE PET影像中复发的生长活性脑膜瘤的病例研究报告
Brooke C Braman,Kanish Mirchia,Javier E Villanueva-Meyer et al.
Brooke C Braman et al.