Rahim Abo Kasem,Lydia A Leavitt,Gina Genova et al.
Rahim Abo Kasem et al.
Purpose: High-grade gliomas are among the most treatment-resistant cancers, with few therapies improving survival despite hundreds of clinical trials. The biostatistical parameters used to design these trials are critical...
Time matters: The prognostic impact of diagnostic delay on survival in primary central nervous system lymphoma-a single-center, retrospective real-world study [0.03%]
时间就是生命：一项单中心回顾性真实世界研究评估诊断延迟对原发中枢神经系统淋巴瘤预后和生存期的影响
Louisa Lehner,Louisa von Baumgarten,Jonas Reis et al.
Louisa Lehner et al.
Abstract: BackgroundPrimary central nervous system lymphoma (PCNSL) is a rare and aggressive malignancy that frequently mimics other central nervous system (CNS) diseases, leading to diagnostic delays. Given its often non...
Evaluation of sex differences in survival among glioblastoma patients treated with immune checkpoint inhibitors [0.03%]
评估免疫检查点抑制剂治疗胶质母细胞瘤患者的生存率性别差异
Vihang Nakhate,Catharina Westergaard,Zhou Lan et al.
Vihang Nakhate et al.
Background: Sex differences in glioblastoma (GBM) are recognized, but their treatment implications remain unclear. Recent preclinical studies have characterized mechanisms of sex-biased anti-tumor immunity in GBM, and hav...
Beyond proof-of-concept: Validating robust automated diffuse lower-grade glioma segmentation for clinical applications in longitudinal follow-up [0.03%]
超越概念验证：在纵向随访的临床应用中验证自动弥漫性低级别胶质瘤分割的稳健性
Jeremy Deverdun,Guillaume Clain,Margaux Verdier et al.
Jeremy Deverdun et al.
Background: Monitoring diffuse lower-grade glioma (DLGG) evolution on MRI is challenging due to their infiltrative nature and post-surgical deformations. The RANO criteria recommend assessing the 2D tumor size, but volume...
Enhanced glioblastoma immunotherapy via SMAC mimetic dose escalation and TGFβ blockade [0.03%]
通过SMAC模拟物剂量增加和TGFβ阻滞增强胶质母细胞瘤免疫治疗
Kyle Malone,Melanie Dugas,Nathalie Earl et al.
Kyle Malone et al.
Background: Glioblastoma (GBM) is the most common primary brain tumor with an overall survival under 21 months. Despite extensive research effort, patient outcomes have improved minimally over the past several decades. Th...
Lou Van Eupen,Anthony Waked,Irina Primac et al.
Lou Van Eupen et al.
Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by rapid progression, extensive inter- and intra-tumoral heterogeneity, and resistance to standard-of-care, including radiotherapy. Radiotherapy remains a cornerst...
Pre-treatment journey and outcome for children with intracranial non-germinomatous germ cell tumors-the Shanghai experience [0.03%]
非生殖细胞瘤型颅内生殖细胞肿瘤患儿的前期治疗经历及结局——上海儿童医学中心的经验总结
Anan Zhang,Xiang Huang,Yijin Gao et al.
Anan Zhang et al.
Background: Non-germinomatous germ cell tumors (NGGCTs) occur 3.5 times more frequently in Chinese children than in western populations. This study aimed to evaluate treatment outcomes, prognostic factors, and diagnostic ...
Targeted next-generation sequencing-based sequencing of cell-free DNA in cerebrospinal fluid uncovers cancer-specific mutations in patients with brain cancer using a widely available panel [0.03%]
基于目标下一代测序技术对脑癌患者脑脊液中游离DNA的测序可利用现有的基因组面板发现癌症特异性的突变
Alexander Köpp,Peter Westarp,Marta Nowak et al.
Alexander Köpp et al.
Background: The gold standard for the diagnosis of brain tumors comprises neurosurgical biopsies or resections for tissue acquisition. Depending on the anatomical location of the tumor, this might not always be feasible. ...
Plasma extracellular vesicle sampling from glioblastoma demonstrates a small RNA signature indicative of disease and identifies lncRNA RPPH1 as a biomarker [0.03%]
胶质母细胞瘤血浆外泌体取样显示了指示疾病的小RNA信号，并确定lncRNA RPPH1为生物标志物
Jae Ho Han,Gabriel Wajnberg,Kathleen M Attwood et al.
Jae Ho Han et al.
Background: Glioblastoma (GBM) and cells of the tumour microenvironment (TME) secrete extracellular vesicles (EVs) into the plasma that contain genetic and protein cargo, which function in paracrine signaling. Isolation o...
The influence of VEGFR-2 blockade and focused ultrasound blood-brain barrier opening on the glioma-immune landscape [0.03%]
VEGFR-2阻断和声动力血脑屏障开孔对胶质瘤免疫微环境的影响研究
Katherine M Nowak,Matthew R Hoch,Victoria R Breza et al.
Katherine M Nowak et al.
Background: Glioblastoma (GBM) is an aggressive brain cancer with limited treatment options and high recurrence rates. The blood-brain barrier (BBB) impedes therapeutic delivery for the brain, limiting systemic treatment ...