Predictive radiomics for evaluation of cancer immune signature in glioblastoma: The PRECISE-GBM study [0.03%]
基于放射组学的胶质母细胞瘤癌症免疫标志物评估研究：PRECISE-GBM研究
Prajwal Ghimire,Junjie Li,Liu Yaou et al.
Prajwal Ghimire et al.
Background: Radiogenomics allows identification of radiological biomarkers for genomic phenotypes. In glioblastoma, these biomarkers could potentially complement patient stratification strategies. We aim to develop and an...
Systematic decoding the functional role of human endogenous retrovirus-derived RNAs in medulloblastoma [0.03%]
系统解码人类内源性逆转录病毒衍生RNA在髓母细胞瘤中的功能作用
Jiaming Zhao,Wei Yang,Tingting Wang et al.
Jiaming Zhao et al.
Background: Medulloblastoma (MB) is the most common malignant pediatric brain tumor, but its pathogenesis remains poorly understood. Although human endogenous retrovirus-derived RNAs (hervRNAs) are implicated in tumorigen...
Inhibition of chemokine CXCL12 modulates the tumor microenvironment in glioblastoma and potentiates immune checkpoint inhibitor efficacy in a tissue-specific manner [0.03%]
化学因子CXCL12抑制可调节胶质母细胞瘤中的肿瘤微环境，并以组织特异性的方式增强免疫检查点抑制剂的疗效
Chen Makranz,Caitlin Huguely,Meili Zhang et al.
Chen Makranz et al.
Background: Immunotherapy, while effective for many extra-cranial solid tumors, has not shown benefits against glioblastoma. Limited T cell infiltration and an immunosuppressive tumor microenvironment (TME) are among the ...
An ambispective, observational real-world study of tumor-treating fields for treatment of Chinese patients with newly diagnosed or recurrent/progressive glioblastoma [0.03%]
一项关于肿瘤治疗场对新诊断或复发/进展胶质母细胞瘤中国患者的前瞻性、观察性真实世界研究
Guanzhang Li,Xiaoguang Qiu,Wei Zhang et al.
Guanzhang Li et al.
Background: Glioblastoma is the most common and aggressive central nervous system malignancy with poor prognosis. Tumor-treating fields (TTFields), approved in China in May 2020, represents a significant advancement in GB...
Understanding system-level barriers to pediatric neuro-oncology in Ghana: Qualitative insights from frontline healthcare professionals [0.03%]
了解加纳儿科神经肿瘤学系统级障碍：一线卫生专业人员的定性见解
Joseline Haizel-Cobbina,Lakshmi Suryateja Gangavarapu,Angela Lamina et al.
Joseline Haizel-Cobbina et al.
Background: Previous studies have shown significant gaps in the timely delivery of pediatric neurosurgical-oncologic care in sub-Saharan Africa despite the significant patient volume. The study aims to elucidate how the h...
Petra Bintintan-Socaciu,Shuroq Taju,Angela Elia et al.
Petra Bintintan-Socaciu et al.
Background: Maximal safe awake resection is the standard for diffuse gliomas, as it optimizes extent of resection while preserving functional integrity. Progressive loss of accuracy during neurocognitive testing may precl...
Females experience a greater benefit from surgical resection in an immune-dependent manner in a preclinical glioblastoma model [0.03%]
免疫依赖性方式的外科手术切除术能够有效改善脑胶质母细胞瘤模型中的女性患者病情治疗方法的研究
Josephine Volovetz,Andrea Alvarez-Vazquez,Juyeun Lee et al.
Josephine Volovetz et al.
Introduction: Glioblastoma (GBM) is 1.6 times more common in males, who also have a shorter survival. Recent evidence has demonstrated sex differences in the immune response to GBM. While preclinical models are often used...
Prediction of treatment failure in patients with glioblastoma with perfusion MRI and molecular biomarkers [0.03%]
基于灌注MRI和分子生物标志物预测胶质母细胞瘤患者的治疗失败风险
Riccardo Ludovichetti,Jordan Villiers,Gergely Bertalan et al.
Riccardo Ludovichetti et al.
Background: Predicting early treatment failure in glioblastoma remains challenging. Given the median survival of 13.5 months, better prognostic biomarkers are needed. This study aimed to identify predictors of early treat...
Imaging patterns of glioblastoma progression: Comparative analysis of sequential proton boost versus conventional photon therapy [0.03%]
胶质母细胞瘤进展的影像学模式：质子 boost 与常规光子治疗的序贯对比分析
Ludwig Singer,Hanna Gött,Viet Duc Vu et al.
Ludwig Singer et al.
Background: Glioblastoma is the most aggressive brain tumor, with a 5-year survival rate of only 8%. Radiotherapy plays a crucial role in multimodal treatment. With novel therapy approaches emerging, we evaluated specific...
Surgical resection or bevacizumab for treatment of radiation necrosis-associated cerebral edema in patients with brain metastases: A single center experience [0.03%]
外科手术切除与贝伐单抗治疗脑转移瘤放疗后脑坏死性脑水肿的疗效比较：一项单中心研究
Miles E Dijkstra,Joost W Schouten,Lotte Plegt et al.
Miles E Dijkstra et al.
Introduction: Cerebral radiation necrosis (RN) is a frequent adverse event of stereotactic radiotherapy (SRT) for brain metastases. This retrospective, single-center cohort study compares surgical resection with bevacizum...