The Src inhibitor peptide TAT-Cx43266-283 improves survival in an intracranial murine model of lung cancer brain metastasis [0.03%]
Src抑制肽TAT-Cx43266-283可提高肺癌脑转移小鼠模型的生存率
Pilar Cerveró-García,Enrique Jiménez-Madrona,Andrea Álvarez-Vázquez et al.
Pilar Cerveró-García et al.
Background: TAT-Cx43266-283 is a novel Src inhibitor, which has shown noteworthy antitumor effects in preclinical models of glioblastoma. Because Src plays a pivotal role in several tumor types, including lung cancer brai...
High human cytomegalovirus antigen expression in pediatric medulloblastoma tissue is associated with poor event-free survival [0.03%]
人巨细胞病毒抗原在儿童髓母细胞瘤组织中高表达与较差的无事件生存率相关
Maria F De la Cerda-Vargas,Jens Schittenhelm,Martin Ebinger et al.
Maria F De la Cerda-Vargas et al.
Background: Despite advancements in treatment, 5-year survival for medulloblastoma (MB) remains 60%-70%. Human cytomegalovirus (HCMV) has been implicated as an oncomodulator in MB, but its impact on survival has not been ...
Retrograde longitudinal imaging analyses of IDH-wildtype glioblastoma reveal its clinical timeline from radiological birth to death [0.03%]
IDH野生型胶质母细胞瘤的逆行纵向影像分析揭示了其从放射学出生到死亡的临床时间线
Ryota Shigeeda,Ichiyo Shibahara,Yasushi Orihashi et al.
Ryota Shigeeda et al.
Background: Glioblastoma (GB), IDH-wildtype, and low-grade glioma appear indistinguishable in their early pre-symptomatic phase, yet GB follows a far more aggressive clinical course. While genomic studies suggest a "biolo...
Development of an integrated risk stratification model for metastatic medulloblastoma (M2/3) using clinical, radiologic, and molecular variables [0.03%]
基于临床、影像学和分子变量的髓母细胞瘤(M2/3)综合风险分层模型的建立
Wen-Tao Zhou,Tao Wu,Yu-Fei Lu et al.
Wen-Tao Zhou et al.
Background: Approximately 20% of medulloblastoma (MB) patients are diagnosed with metastatic disease and typically exhibit extremely poor clinical outcomes. This study aimed to investigate potential prognostic factors aff...
Single-cell RNA sequencing suggests different progenitor lineages between IDH mutant and IDH wt glioma [0.03%]
单细胞RNA测序提示IDH突变型和野生型胶质瘤具有不同的祖细胞系
Iyad Alnahhas,Allison Kayne,Mehak Majid Khan et al.
Iyad Alnahhas et al.
Introduction: Single-cell RNA sequencing has elucidated the heterogeneity in cancer. Single-cell glioblastoma (GBM) analyses have also proposed the resemblance of GBM cells to radial glia and outer radial glia (oRG) suppo...
Tertiary lymphoid structures in glioblastoma: Association with multiparametric MRI imaging phenotypic features and patient survival [0.03%]
胶质母细胞瘤中的三级淋巴器官与多模态MRI表型特征及患者预后的相关性研究
Qing Zhou,Peng Zhang,Caiqiang Xue et al.
Qing Zhou et al.
Background: Tertiary lymphoid structures (TLSs) correlate with improved survival in various cancers, but their prognostic significance and imaging correlations in glioblastoma (GBM) remain unclear. This study investigated...
Ketogenic diet therapy for high-grade gliomas combined with standard treatment using an angiogenesis inhibitor: An exploratory pilot study on feasibility [0.03%]
生酮饮食联合标准抗血管生成药物治疗高分级胶质瘤的可行性探索性研究
Takashi Sasayama,Kazuhiro Tanaka,Hiroaki Nagashima et al.
Takashi Sasayama et al.
Background: Altered tumor metabolism has renewed interest in ketogenic strategies, despite limited clinical evidence in glioma. Whereas the ketogenic diet (KD) alone elevates intratumoral amino acids, bevacizumab (BEV) co...
From the gut to the brain: The involvement of the gut microbiota in the development and progression of glioblastoma [0.03%]
从肠道到大脑：肠道微生物群在胶质母细胞瘤发病和进展中的作用
Daniela Toumazi,Christiana Charalambous,Constantina Constantinou et al.
Daniela Toumazi et al.
Glioblastoma (GB) is the most malignant tumor in the adult central nervous system (CNS), presenting substantial treatment challenges due to its infiltrative nature, heterogeneity and immunosuppressive environment it creates. Current therape...
Diagnosing growth in low-grade gliomas with and without artificial intelligence-measured longitudinal volume measurements: A retrospective observational study [0.03%]
基于人工智能的纵向体积测量在低级别胶质瘤生长诊断中的应用：回顾性观察研究
Hassan M Fathallah-Shaykh,Houman Sotoudeh,Markus Bredel et al.
Hassan M Fathallah-Shaykh et al.
Background: Low-grade or grade 2 diffuse gliomas (LGG) infiltrate the brains leading to significant neurological morbidity. This retrospective observational study evaluates the ability of AI-assisted volumetric analysis t...
Age is not enough: Clinical and therapeutic predictors of survival in elderly patients with de novo glioblastoma [0.03%]
年龄不足以为证：老年原发胶质母细胞瘤患者的临床和治疗生存预测因素
Raquel Gutiérrez-González,Zulema Herrero,Ana Royuela et al.
Raquel Gutiérrez-González et al.
Background: This study aims to analyze survival outcomes in patients over 65 years old with a de novo diagnosis of glioblastoma and to identify factors that impact survival to guide management decisions in this population...