Yosef Ellenbogen,Alexander P Landry,Leeor S Yefet et al.
Yosef Ellenbogen et al.
Meningiomas are the most common primary intracranial tumor in adults. Traditional bulk genomic and histopathological analyses have provided valuable insights into meningioma biology. Recent advances in single-cell sequencing technologies ha...
Single-cell multi-omic techniques highlight the diverse composition and intercellular interactions of the vestibular schwannoma tumor microenvironment [0.03%]
单细胞多组学技术揭示前庭神经鞘瘤肿瘤微环境的多样化组成及细胞间相互作用
Shree S Pari,Sangami Pugazenthi,Albert H Kim et al.
Shree S Pari et al.
Vestibular schwannomas (VS) are tumors arising from Schwann cells of the vestibulocochlear nerve, often leading to hearing loss, gait imbalance, and other neurological complications. Recently, molecular profiling of VS using bulk and single...
Pitfalls in analysis and interpretation of single-cell RNA-seq data in cancer [0.03%]
癌症单细胞RNA测序数据分析和解释的陷阱
Itay Tirosh
Itay Tirosh
Single-cell and single-nuclei RNA-seq (sc/snRNA-seq) have become a central approach in cancer research, and their widespread impact has been enabled by various computational tools developed specifically for sc/snRNA-seq analysis. Neverthele...
Towards a sub-regional network of neuro-oncology in West Africa: An imperative to bridge the inequalities in care and research and to improve clinical outcomes [0.03%]
面向西非神经肿瘤亚区域网络的建设：缩小护理和研究不平等、改善临床结果势在必行
Mèhomè Wilfried Dossou
Mèhomè Wilfried Dossou
A phase 2 study of abemaciclib in patients with brain metastases secondary to non-small cell lung cancer or melanoma [0.03%]
阿贝西利治疗非小细胞肺癌或黑色素瘤继发性脑转移患者的II期研究
Solmaz Sahebjam,Danielle A Bazer,Emilie Le Rhun et al.
Solmaz Sahebjam et al.
Background: Abemaciclib is a selective cyclin-dependent kinase 4 and 6 inhibitor that penetrates the blood-brain barrier, resulting in comparable concentrations in tissue and plasma. The primary objective of this nonrando...
Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications [0.03%]
胶质母细胞瘤中的核和膜结合激素受体：表达、功能及治疗意义
Alice Gantner,Hélène Dubois-Pot-Schneider,Hélène Dumond
Alice Gantner
The 2021 WHO classification of brain tumors emphasizes integrating molecular features with histopathology, notably redefining astrocytoma and glioblastoma entities. Recent research underscores the influence of sex hormones in glioblastoma d...
Development and validation of the Home time and Overall survival after Metastatic spine tumor surgery Estimator (HOME score) [0.03%]
转移性脊柱肿瘤手术后家庭生活时间和总生存期的开发和验证(HOME评分)
Husain Shakil,Armaan K Malhotra,Christopher S Lozano et al.
Husain Shakil et al.
Background: This study reports the development and validation of the Home time and Overall survival after Metastatic spine tumor surgery Estimator (HOME score). ...
Epigenetic maintenance of the injury response state in glioblastoma stem cells [0.03%]
表观遗传调控胶质瘤干细胞损伤应答状态的作用机制研究
Fatemeh Molaei,Graham MacLeod,Shahan Haider et al.
Fatemeh Molaei et al.
Background: Glioblastoma (GBM) is a common and highly lethal type of primary brain tumor in adults. Therapeutic failure is partly attributed to a fraction of glioblastoma stem cells (GSCs) that show high levels of heterog...
Proteomics in IDH-mutated diffuse lower-grade glioma: a scoping review [0.03%]
IDH突变的弥漫性低级别胶质瘤蛋白质组学的综述性研究
Carl-Johan Kihlstedt,Anna Dénes,Alireza Mansouri et al.
Carl-Johan Kihlstedt et al.
Background: Therapeutic options and biomarkers for isocitrate dehydrogenase-mutated (IDHmut) diffuse lower-grade glioma (dLGG), WHO grade 2-3, are limited. Global quantitative proteomics has aided the discovery of novel m...
A Cre-mediated copy number variant compromises the reliability of a LoxP-STOP-LoxP- PLAG1 driven brain tumor model [0.03%]
一个Cre诱导的拷贝数变异影响了一种PLAG1受控于LoxP-STOP-LoxP的小脑瘤模型的可靠性
Jan Vaillant,Sangita Pal,Jan Müller et al.
Jan Vaillant et al.
Background: The developmental context in which genetic alterations occur is crucial to understand disease progression. In pediatric cancer, modeling tumor formation in the right cell type is necessary to faithfully recapi...