miRNA liquid biopsy combined with MRI radiomics for improved outcome prediction in glioblastoma: integrated machine learning analysis of longitudinal data from 73 patients [0.03%]
结合液体活检和磁共振影像组学的机器学习算法用于改善胶质母细胞瘤患者的预后：基于73例患者纵向数据分析
Owen P Leary,Zhuoqi Ma,Hyeyeon Hwang et al.
Owen P Leary et al.
Background: While both MRI radiomics and miRNA liquid biopsy have shown promise for glioblastoma prognostication, state-of-the-art methods may enable novel integration of multimodal data to further optimize performance. ...
Comparison of 2 stereotactic radiotherapy regimens for brain metastases: Is higher always better? [0.03%]
立体放射治疗脑转移瘤：剂量越高疗效越好吗？
Vincent Bourbonne,Moncef Morjani,Brieg Dissaux et al.
Vincent Bourbonne et al.
Introduction: Stereotactic radiosurgery (SRS) has become a preferred treatment for brain metastases (BMs) due to its precision, minimizing neurocognitive side effects compared to whole-brain radiotherapy. However, the opt...
Educational needs in neuro-oncology: Insights from the European Society for Medical Oncology Central Nervous System Faculty Survey [0.03%]
神经肿瘤学的教育需求：来自欧洲医学肿瘤学会中枢神经系统 faculty 调查的见解
Oriol Mirallas,Giulia Cerretti,Anna Sophie Berghoff et al.
Oriol Mirallas et al.
Background: Primary central nervous system (CNS) tumors are rare malignancies with limited treatment options, resulting in high mortality. Unlike other solid tumors, CNS tumors present unique challenges that impact the he...
Combining the KRASG12C inhibitor adagrasib with anti-PD-1 immunotherapy improves overall survival and prevents recurrence in preclinical models of brain metastasis [0.03%]
KRAS G12C抑制剂adagrasib联合抗PD-1免疫疗法可改善小鼠脑转移瘤模型的总生存率并防止复发
Consuelo Torrini,Naema Nayyar,Gregory R Wojtkiewicz et al.
Consuelo Torrini et al.
Background: Despite advances in treatment, brain metastasis (BM) management remains a significant challenge. Adagrasib is a brain-penetrant KRASG12C inhibitor active in patients with BM. KRAS mutations are linked with imm...
Intraoperative, interstitial brachytherapy in newly diagnosed brain metastases through cesium-131 collagen tile implant: A multi-institutional case series [0.03%]
新型脑转移瘤术中腔内间质放射治疗（铯-131胶原植入模板）：多中心病例系列研究
Carlin Chuck,Mazen Taman,Trenton Kite et al.
Carlin Chuck et al.
Background: Cesium-131 collagen tile has gained traction as an intraoperative brachytherapy platform for recurrent intracranial tumors, but outcome data in newly diagnosed brain metastases (nBM) remain sparse, with fewer ...
Prospective randomized trial of tumor-treating fields with chemoradiation in newly diagnosed glioblastoma [0.03%]
新诊断的胶质母细胞瘤电场治疗联合化学放疗的前瞻随机试验
Dror Limon,Felix Bokstein,Deborah T Blumenthal et al.
Dror Limon et al.
Background: Tumor-treating fields (TTFields) have demonstrated efficacy in newly diagnosed glioblastoma (ndGBM) when combined with adjuvant temozolomide (TMZ). Preclinical studies suggest that TTFields enhance the therape...
Spherical radiomics for radiogenomic assessment of glioblastoma heterogeneity [0.03%]
球形放射组学在胶质母细胞瘤异质性影像基因分型中的应用
Haotian Feng,Ke Sheng
Haotian Feng
Background: To develop and validate a novel spherical radiomics framework for predicting key molecular biomarkers-including MGMT promoter methylation, EGFR, and PTEN mutation status-and survival in glioblastoma (GBM) pati...
Cellular senescence escape and antiviral response discriminate glioblastoma from lower-grade gliomas [0.03%]
细胞衰老逃逸和抗病毒反应可区分胶质母细胞瘤与低级别胶质瘤
Dominika Maurencova,Michaela Sadibolova,Monika Zarska et al.
Dominika Maurencova et al.
Background. Cellular senescence is a negative prognostic indicator in glioblastoma (GB). However, the specific cell types exhibiting senescence and the molecular mechanisms by which senescent cells (SCs) contribute to GB pathogenesis remain...
A common signature of brain metastases among patients with breast cancer, melanoma, and lymphoma [0.03%]
乳腺癌、黑色素瘤和淋巴瘤患者脑转移的共有特征
Thuy Thi Nguyen,Duc Manh Hoang,Tai Van Nguyen et al.
Thuy Thi Nguyen et al.
Background: Despite considerable improvement in cancer treatments, brain metastases are still challenging daily practice in oncology. Their biology remains largely unknown with limited data obtained from brain metastatic ...
OLIG2-STAT5 cooperation supports glioma stem cell maintenance and proliferation in glioblastoma [0.03%]
OLIG2-STAT5合作可促进胶质母细胞瘤中的胶质瘤干细胞的维持和增殖
Aunay Miller,James McNamara,Mylan R Blomquist et al.
Aunay Miller et al.
Background: Glioblastoma (GBM) is driven, in part, by glioma stem cells (GSCs), which sustain therapeutic resistance and recurrence. OLIG2 is a key regulator of GSC programs but the signaling pathways that cooperate with ...