Association between time to surgery and survival in patients with initially diagnosed WHO 2021 grade 4 gliomas [0.03%]
2021年WHO IV级胶质瘤患者初始诊断后手术时机与生存时间的关系
Haruka Kanamitsu,Eiichi Ishikawa,Shunichiro Miki et al.
Haruka Kanamitsu et al.
Background: Glioblastoma (GBM) and other WHO 2021 grade 4 gliomas are highly aggressive tumors treated with maximal safe resection followed by chemoradiation. Although these tumors grow rapidly, the optimal timing of surg...
Ahmad Ozair,Bilal Moiz,Pavlos Anastasiadis et al.
Ahmad Ozair et al.
Individuals diagnosed with primary brain tumors (PBTs) experience major morbidity and mortality, compounded by the risks associated with standard-of-care brain-directed therapeutic approaches. Recurrence remains inevitable in patients with ...
Focused ultrasound for enhancing cell-based immunotherapies in neuro-oncology [0.03%]
聚焦超声在神经肿瘤细胞治疗中的应用研究
Thomas Sherlock,Andrew T Thede,Natasha D Sheybani
Thomas Sherlock
Cancers of the brain remain notoriously difficult to treat because of the unique and complex barriers imposed by the central nervous system and tumor microenvironment. Current therapeutic paradigms remain largely insufficient to achieve dur...
Development of skull-implanted ultrasound for blood-brain barrier opening and drug delivery in neuro-oncology [0.03%]
颅内植入式超声波血脑屏障开启及药物输送技术在神经肿瘤学中的开发应用研究
Karl J Habashy,Victor A Arrieta,Benedikt Haupt et al.
Karl J Habashy et al.
The blood-brain barrier (BBB) poses a significant challenge for the treatment of brain tumors as it limits the passage of most circulating drugs into the brain. Low-intensity ultrasound with microbubbles safely and transiently opens the BBB...
Focused ultrasound in pediatric neuro-oncology: Current applications and future directions [0.03%]
儿童神经肿瘤学中的聚焦超声：当前应用及未来方向
Catherine Lin,Maheleth Llinas,Nir Lipsman et al.
Catherine Lin et al.
Focused ultrasound (FUS) is a minimally invasive procedure with recent applications to patients with neurosurgical conditions. To date, most neuro-oncologic applications of FUS have occurred in the adult population to target high-grade glio...
Focused ultrasound in neuro-oncology: Realizing the promise of a noninvasive future [0.03%]
神经肿瘤学中的聚焦超声：实现非侵入性治疗的未来承诺
Ying Meng,Nir Lipsman
Ying Meng
Ahmad Ozair,Bilal Moiz,Pavlos Anastasiadis et al.
Ahmad Ozair et al.
Brain metastases (BMs) increasingly represent a significant cause of morbidity and mortality in cancer patients. The efficacy of systemic therapies for BMs, in contrast to extracranial metastases (EMs), remains limited secondary to a host o...
Noninvasive enrichment of circulating tumor biomarkers in a mouse model of diffuse midline glioma using focused ultrasound [0.03%]
利用聚焦超声在弥漫性中线胶质瘤小鼠模型中非侵入性富集循环肿瘤生物标志物
Dingyue Zhang,Yimei Yue,Yan Gong et al.
Dingyue Zhang et al.
Background: Diagnosing diffuse midline glioma (DMG) through invasive tissue biopsies is challenging due to the tumor's eloquent location at the pons. Liquid biopsies offer a promising noninvasive alternative; however, the...
Current state and future of clinical-focused ultrasound devices in neuro-oncology [0.03%]
神经肿瘤学中临床专用超声设备的现状与未来
Chrit T Moonen,Neal F Kassell
Chrit T Moonen
This review provides a comprehensive account of the current state and future directions in clinical-focused ultrasound (FUS) devices, highlighting their transformative potential in neuro-oncology. FUS is a versatile, early-stage, therapeuti...
Exceptional response of radiotherapy-naïve cranial meningiomas to dual immune checkpoint blockade in BAP1 tumor predisposition syndrome [0.03%]
BAP1肿瘤易感综合征患者未经放疗的颅内脑膜瘤对双免疫检查点抑制的异常反应
Gary L Gallia,Christine L Hann,Calixto-Hope G Lucas et al.
Gary L Gallia et al.
Meningiomas are the most common primary central nervous system tumors, and while most are benign, atypical and anaplastic variants frequently recur and have limited effective treatment options. Recent trials of PD-1 blockade in unselected m...