Disease burden and unmet needs in adults with neurofibromatosis type 1 and plexiform neurofibromas: A systematic literature review [0.03%]
I型神经纤维瘤病伴丛状神经纤维瘤成人患者的疾病负担及未满足需求：系统性文献回顾
Maciej Mrugala,Ayo Adeyemi,Juliet Johns et al.
Maciej Mrugala et al.
Background: Neurofibromatosis type 1 (NF1) is a multisystem genetic condition. Up to 50% of individuals with NF1 develop plexiform neurofibromas (PN) that can cause pain and significant morbidity, impairing quality of lif...
The glioblastoma GBMdrug1000 dataset resource provides directions for future small molecule drug discovery [0.03%]
胶质母细胞瘤GBMDrug1000数据集资源为小分子药物的未来发现提供方向
Lavinia-Lorena Pruteanu,Olivier J M Béquignon,Yoran Broersma et al.
Lavinia-Lorena Pruteanu et al.
Background: We previously created a glioblastoma (GBM) DrugBank containing curated information on chemical structure, molecular target activity, and chemical biology for 500 compounds. This study expands the dataset to 11...
Metformin exposure after glioblastoma diagnosis and mortality: A large population-based study [0.03%]
二甲双胍暴露与胶质母细胞瘤预后之间的关系：基于人群的大型研究
Vittorio Maio,Roshani Shah,Manisha Lin et al.
Vittorio Maio et al.
Background: Glioblastoma (GBM) is an aggressive primary brain malignancy with limited therapeutic options and poor survival outcomes. Recent real-world studies and early-phase clinical trials evaluating metformin have yie...
Rethinking treatment de-escalation in elderly glioblastoma: Lessons from a multicenter real-world cohort [0.03%]
基于多中心真实世界队列的老年人胶质母细胞瘤治疗降级的再思考
Orit Furman,Eva Falah,Inbar Dvir et al.
Orit Furman et al.
Background: Glioblastoma (GBM) in elderly patients (≥65 years) carries a poor prognosis and higher treatment toxicity. Consequently, many receive de-escalated regimens, often guided by MGMT promoter methylation. However,...
Emotional distress impairs immune checkpoint blockade efficacy in recurrent high-grade glioma: Insights from tumor in situ fluid analysis [0.03%]
情绪障碍会损害复发性高级别胶质瘤的免疫检查点阻滞疗效：来自肿瘤原位流体分析的启示
Dayang Wang,Jiubing Zhang,Guanzheng Liu et al.
Dayang Wang et al.
Background: Immune checkpoint blockade (ICB) therapy has shown limited benefit in recurrent high-grade glioma (HGG), in part due to an immunosuppressive tumor microenvironment. Emotional distress (ED) is known to alter im...
Focused ultrasound-enhanced cell therapy for brain tumors: Summary of roundtable discussions [0.03%]
聚焦超声增强型细胞疗法治疗脑瘤：圆桌会议讨论摘要
Frederic Padilla,Costas Arvanitis,Catherine M Bollard et al.
Frederic Padilla et al.
Cell-based immunotherapies have emerged as promising strategies for brain tumors, offering the potential for targeted and durable antitumor responses. However, their efficacy has been limited by challenges unique to the central nervous syst...
Special Issue: The Evolving Landscape of Single-Cell Genomics in CNS and PNS Oncology [0.03%]
单细胞基因组学在中枢和外周神经系统的肿瘤学中的演变景观专题研讨会
Yosef Ellenbogen,Mario L Suva,Itay Tirosh
Yosef Ellenbogen
Redefining the immune microenvironment of gliomas in the era of single-cell genomics [0.03%]
单细胞基因组学时代的胶质瘤免疫微环境再定义
L Nicolas Gonzalez Castro,Vrishabhadev Sathish Kumar,Mario L Suva et al.
L Nicolas Gonzalez Castro et al.
Infiltrating gliomas are the most common primary malignant brain tumor and remain universally fatal. Over the past decade, advances in single-cell technologies, including single-cell RNA sequencing, have significantly advanced our understan...
Single-cell transcriptomic profiling of malignant peripheral nerve sheath tumors [0.03%]
恶性外周神经鞘瘤的单细胞转录组分析
Chloe Gui,Severa Bunda,Mira Li et al.
Chloe Gui et al.
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas arising from Schwann cells and characterized by marked cellular and molecular heterogeneity. Although bulk multi-omic studies have provided valuable insights into MPN...
Single-cell advances in the investigation of the pathogenesis and treatment of brain metastasis [0.03%]
单细胞技术在脑转移发病机制和治疗研究中的进展
Robert S Porter,Clara Alves-Pereira,Priscilla K Brastianos
Robert S Porter
Brain metastasis remains a significant cause of morbidity and mortality for cancer patients with limited treatment options. Single-cell RNA-seq has greatly expanded our ability to study cancer and metastasis, particularly in our assessment ...