MR spectroscopic imaging predicts early response to anti-angiogenic therapy in recurrent glioblastoma [0.03%]
磁共振波谱成像预测复发性胶质母细胞瘤抗血管生成治疗的早期疗效
Pratik Talati,Mohamed El-Abtah,Daniel Kim et al.
Pratik Talati et al.
Background: Determining failure to anti-angiogenic therapy in recurrent glioblastoma (GBM) (rGBM) remains a challenge. The purpose of the study was to assess treatment response to bevacizumab-based therapy in patients wit...
The role of RB1 alteration and 4q12 amplification in IDH-WT glioblastoma [0.03%]
IDH野生型胶质母细胞瘤中RB1改变和4q12扩增的作用
Antonio Dono,Arvind V Ramesh,Emily Wang et al.
Antonio Dono et al.
Background: Recent studies have identified that glioblastoma IDH-wildtype (GBM IDH-WT) might be comprised of molecular subgroups with distinct prognoses. Therefore, we investigated the correlation between genetic alterati...
5-Aminolevulinic acid-guided resection improves the overall survival of patients with glioblastoma-a comparative cohort study of 343 patients [0.03%]
5-氨基酮戊酸引导的手术可改善胶质母细胞瘤患者的总体生存率——来自343名患者比较队列研究的证据
Asfand Baig Mirza,Ioannis Christodoulides,Jose Pedro Lavrador et al.
Asfand Baig Mirza et al.
Background: 5-Aminolevulic acid-guided surgery (5-ALA-GS) improves the extent of resection (EoR) and progression-free survival in patients with glioblastoma multiforme (GBM). ...
Systematic review and network meta-analysis of the efficacy of existing treatments for patients with recurrent glioblastoma [0.03%]
复发性胶质母细胞瘤现有治疗方法疗效的系统评价和网络 meta 分析
Anna Schritz,Nassera Aouali,Aurélie Fischer et al.
Anna Schritz et al.
Background: Despite advances in the treatment of cancers over the last years, treatment options for patients with recurrent glioblastoma (rGBM) remain limited with poor outcomes. Many regimens have been investigated in cl...
Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults [0.03%]
成人H3 K27M突变弥漫性半球胶质瘤的临床特征分析
Thiébaud Picart,Marc Barritault,Delphine Poncet et al.
Thiébaud Picart et al.
Background: Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a distinct type of aggressive brain tumors. Although initially described in children, they can also affect adults. The aims of this stud...
Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma [0.03%]
一种靶向TGF-β和PD-L1的双功能融合蛋白Bintrafusp alfa（M7824）：复发性胶质母细胞瘤Ⅰ期临床试验扩展队列的研究结果
Mustafa Khasraw,Michael Weller,David Lorente et al.
Mustafa Khasraw et al.
Background: For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy plus temozolomide. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed ...
NBAT1/CASC15-003/USP36 control MYCN expression and its downstream pathway genes in neuroblastoma [0.03%]
神经母细胞瘤中NBAT1/CASC15-003/USP36调控MYCN及其下游通路基因的表达
Prasanna Kumar Juvvuna,Tanmoy Mondal,Mirco Di Marco et al.
Prasanna Kumar Juvvuna et al.
Background: MYCN has been an attractive therapeutic target in neuroblastoma considering the widespread amplification of the MYCN locus in neuroblastoma, and its established role in neuroblastoma development and progressio...
Timing of glioblastoma surgery and patient outcomes: a multicenter cohort study [0.03%]
胶质母细胞瘤手术时机与患者预后的关系：一项多中心队列研究
Domenique M J Müller,Merijn E De Swart,Hilko Ardon et al.
Domenique M J Müller et al.
Background: The impact of time-to-surgery on clinical outcome for patients with glioblastoma has not been determined. Any delay in treatment is perceived as detrimental, but guidelines do not specify acceptable timings. I...
Multiparametric MRI texture analysis in prediction of glioma biomarker status: added value of MR diffusion [0.03%]
多参数磁共振纹理分析在胶质瘤生物标志物状态预测中的应用：扩散加权磁共振的价值评估
Shingo Kihira,Nadejda M Tsankova,Adam Bauer et al.
Shingo Kihira et al.
Background: Early identification of glioma molecular phenotypes can lead to understanding of patient prognosis and treatment guidance. We aimed to develop a multiparametric MRI texture analysis model using a combination o...
Hypermetabolism and impaired cerebrovascular reactivity beyond the standard MRI-identified tumor border indicate diffuse glioma extended tissue infiltration [0.03%]
超出标准MRI识别的肿瘤边界的高度代谢和受损脑血管反应性表明弥漫性胶质瘤浸润组织扩散
Martina Sebök,Christiaan Hendrik Bas van Niftrik,Giovanni Muscas et al.
Martina Sebök et al.
Background: Diffuse gliomas exhibit diffuse infiltrative growth, often beyond the magnetic resonance imaging (MRI)-detectable tumor lesion. Within this lesion, hypermetabolism and impaired cerebrovascular reactivity (CVR)...