Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation [0.03%]
免疫去卷积和时间映射识别出阻碍小鼠低级别视神经胶质瘤形成的间充质靶点及发展间隔期
Amanda de Andrade Costa,Jit Chatterjee,Olivia Cobb et al.
Amanda de Andrade Costa et al.
Background: Brain tumor formation and progression are dictated by cooperative interactions between neoplastic and non-neoplastic cells. This stromal dependence is nicely illustrated by tumors arising in the Neurofibromato...
Multivariate analysis of associations between clinical sequencing and outcome in glioblastoma [0.03%]
多变量分析胶质母细胞瘤临床测序与预后的关联
Peter H Yang,Yu Tao,Jingqin Luo et al.
Peter H Yang et al.
Background: Many factors impact survival in patients with glioblastoma, including age, Karnofsky Performance Status, postoperative chemoradiation, IDH1/2 mutation status, MGMT promoter methylation status, and extent of re...
Integrating morphologic and molecular histopathological features through whole slide image registration and deep learning [0.03%]
基于全片数字化图像配准和深度学习整合形态学和分子病理特征
Kevin Faust,Michael K Lee,Anglin Dent et al.
Kevin Faust et al.
Background: Modern molecular pathology workflows in neuro-oncology heavily rely on the integration of morphologic and immunohistochemical patterns for analysis, classification, and prognostication. However, despite the re...
Osimertinib in advanced EGFR-mutant lung adenocarcinoma with asymptomatic brain metastases: an open-label, 3-arm, phase II pilot study [0.03%]
对于无症状性脑转移的晚期EGFR突变肺腺癌患者，奥希替尼疗效如何：一项开放标签、三臂、Ⅱ期临床试验
Nir Peled,Waleed Kian,Edna Inbar et al.
Nir Peled et al.
Background: Osimertinib is selective for both epidermal growth factor receptor (EGFR)-tyrosine-kinase inhibitor (TKI) sensitizing and Thr790Met mutations. While intracranial activity of osimertinib is documented in larger...
Markedly prolonged disease course, with breakthrough seizures, in a glioma with an isolated IDH1 mutation [0.03%]
单个IDH1突变型胶质瘤患者突破性癫痫发作的病程延长
Michael Drumm,Jessica W Templer,Matthew Tate et al.
Michael Drumm et al.
Irradiation of the subventricular zone and subgranular zone in high- and low-grade glioma patients: an atlas-based analysis on overall survival [0.03%]
基于图谱的分析在高级和低级胶质瘤患者中亚 ventricular 区和次 granular 区辐照对总生存期的影响
Danique E Bruil,Szabolcs David,Steven H J Nagtegaal et al.
Danique E Bruil et al.
Background: Neural stem cells in the subventricular zone (SVZ) and subgranular zone (SGZ) are hypothesized to support growth of glioma. Therefore, irradiation of the SVZ and SGZ might reduce tumor growth and might improve...
A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines [0.03%]
一种多参数药物基因组学再定位策略可预测胶质母细胞瘤细胞系的治疗效果
Ashish H Shah,Robert Suter,Pavan Gudoor et al.
Ashish H Shah et al.
Background: Poor prognosis of glioblastoma patients and the extensive heterogeneity of glioblastoma at both the molecular and cellular level necessitates developing novel individualized treatment modalities via genomics-d...
Mitochondrial DNA copy number as a prognostic marker is age-dependent in adult glioblastoma [0.03%]
线粒体DNA拷贝数的预后价值依赖于年龄在成人胶质母细胞瘤中的作用
Baptiste Sourty,Laure-Marie Dardaud,Céline Bris et al.
Baptiste Sourty et al.
Background: Glioblastoma (GBM) is the most common and aggressive form of glioma. GBM frequently displays chromosome (chr) 7 gain, chr 10 loss and/or EGFR amplification (chr7+/chr10-/EGFRamp). Overall survival (OS) is 15 m...
Radiation-induced neuroinflammation: a potential protective role for poly(ADP-ribose) polymerase inhibitors? [0.03%]
辐射诱导的神经炎症：聚（腺苷二磷酸核糖）聚合酶抑制剂的潜在保护作用？
Rodrigo Gutierrez-Quintana,David J Walker,Kaye J Williams et al.
Rodrigo Gutierrez-Quintana et al.
Radiotherapy (RT) plays a fundamental role in the treatment of glioblastoma (GBM). GBM are notoriously invasive and harbor a subpopulation of cells with stem-like features which exhibit upregulation of the DNA damage response (DDR) and are ...
Long-term effectiveness of Gliadel implant for malignant glioma and prognostic factors for survival: 3-year results of a postmarketing surveillance in Japan [0.03%]
有关恶性胶质瘤的Gliadel植入剂的长期疗效及影响生存率预后的因素：日本上市后再评价3年结果
Toshihiko Iuchi,Akihiro Inoue,Yuichi Hirose et al.
Toshihiko Iuchi et al.
Background: Adjuvant treatment with Gliadel wafers may prolong overall survival (OS) for malignant glioma patients without increasing toxicity. In Japan, the long-term OS of these patients treated with Gliadel 7.7 mg impl...