Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming [0.03%]
鉴定出新的转录因子可以促进多能重编程
Ping Huang,Jieying Zhu,Yu Liu et al.
Ping Huang et al.
Background: Four transcription factors, Oct4, Sox2, Klf4, and c-Myc (the Yamanka factors), can reprogram somatic cells to induced pluripotent stem cells (iPSCs). Many studies have provided a number of alternative combinat...
Paper of October Issue of Stem Cell Reviews and Reports Presents a Novel View on Oogenesis in Adult Mammalian Ovaries [0.03%]
《Stem Cell Reviews and Reports》2019年10月刊长文:提出成年哺乳动物卵巢中卵子发生的全新观点
Sham S Kakar,Mariusz Z Ratajczak
Sham S Kakar
The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies [0.03%]
胎儿期到成人期的造血干细胞转变及其在儿童造血系统恶性肿瘤中的作用
Ryan Mack,Lei Zhang,Peter Breslin Sj et al.
Ryan Mack et al.
As with most organ systems that undergo continuous generation and maturation during the transition from fetal to adult life, the hematopoietic and immune systems also experience dynamic changes. Such changes lead to many unique features in ...
Combining Bone Collagen Matrix with hUC-MSCs for Application to Alveolar Process Cleft in a Rabbit Model [0.03%]
结合hUC-MSCs的骨胶原基质在兔上颌前牙缺损中的应用研究
Xue-Cheng Sun,Hu Wang,Dan Zhang et al.
Xue-Cheng Sun et al.
Background: Most materials used clinically for filling severe bone defects either cannot induce bone re-generation or exhibit low bone conversion, therefore, their therapeutic effects are limited. Human umbilical cord mes...
Pharmacological Inhibition of p38 MAPK Rejuvenates Bone Marrow Derived-Mesenchymal Stromal Cells and Boosts their Hematopoietic Stem Cell-Supportive Ability [0.03%]
p38 MAPK的药理学抑制可增强骨髓来源间充质基质细胞对造血干细胞支持能力的作用并发挥其年轻态功效
Pallavi Budgude,Vaijayanti Kale,Anuradha Vaidya
Pallavi Budgude
The therapeutic value of mesenchymal stromal cells (MSCs) for various regenerative medicine applications, including hematopoietic stem cell transplantations (HSCT), has been well-established. Owing to their small numbers in vivo, it becomes...
Bivalent Regulation and Related Mechanisms of H3K4/27/9me3 in Stem Cells [0.03%]
干细胞中H3K4/27/9me3的双价调控及相关机制研究
Han Sun,Yin Wang,Ying Wang et al.
Han Sun et al.
The "bivalent domain" is a unique histone modification region consisting of two histone tri-methylation modifications. Over the years, it has been revealed that the maintenance and dynamic changes of the bivalent domains play a vital regula...
Augmenting Peripheral Nerve Regeneration with Adipose-Derived Stem Cells [0.03%]
利用来源于脂肪的干细胞来增强外周神经再生
Liangfu Jiang,Thomas Mee,Xijie Zhou et al.
Liangfu Jiang et al.
Peripheral nerve injuries (PNIs) are common and debilitating, cause significant health care costs for society, and rely predominately on autografts, which necessitate grafting a nerve section non-locally to repair the nerve injury. One poss...
New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells [0.03%]
新型hPSC SOX9和INS报告细胞系可促进向胰岛素产生细胞分化过程的观察与优化
Rabea Dettmer,Isabell Niwolik,Ilir Mehmeti et al.
Rabea Dettmer et al.
Differentiation of human pluripotent stem cells into insulin-producing stem cell-derived beta cells harbors great potential for research and therapy of diabetes. SOX9 plays a crucial role during development of the pancreas and particularly ...
Very small embryonic-like stem cells (VSELs) regenerate whereas mesenchymal stromal cells (MSCs) rejuvenate diseased reproductive tissues [0.03%]
非常小的胚胎样干细胞(VSELs)具有组织再生作用而间充质基质细胞(MSCs)具有抗衰老和修复病变组织的作用
Deepa Bhartiya,Pushpa Singh,Diksha Sharma et al.
Deepa Bhartiya et al.
Compared to embryonic and induced pluripotent stem cells, mesenchymal stem/stromal cells (MSCs) have made their presence felt with good therapeutic promise and safety profile. Transplanting MSCs has successfully helped to reverse infertilit...
NFĸB Targeting in Bone Marrow Mesenchymal Stem Cell-Mediated Support of Age-Linked Hematological Malignancies [0.03%]
骨髓间充质干细胞介导的年龄相关血液系统恶性肿瘤的支持中的NFĸB靶向作用
Lauren S Sherman,Shyam A Patel,Marianne D Castillo et al.
Lauren S Sherman et al.
Mesenchymal stem cells (MSCs) can become dysfunctional in patients with hematological disorders. An unanswered question is whether age-linked disruption of the bone marrow (BM) microenvironment is secondary to hematological dysfunction or v...