Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies [0.03%]
造血干细胞衰老机制和潜在的再生策略
Qi Liu,Lijun Zhao,Chengying Li
Qi Liu
Hematopoietic stem cell (HSCs) aging is a complex biological process driven by both cell-intrinsic alterations and extrinsic cues from the bone marrow niche. Understanding these mechanisms is critical for developing therapies against aging-...
Homing and Migration of Umbilical Cord Mesenchymal Stromal Cells in Clinical Applications: Molecular Mechanisms, Translational Barriers, and Therapeutic Optimization [0.03%]
临床应用中脐带间充质基质细胞归巢和迁移的分子机制、转化障碍及治疗优化措施
XueXia Liu,FuJun Liu
XueXia Liu
Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) offer distinct advantages for clinical translation, including accessibility, scalability, and broad immunomodulatory capacity. However, the efficacy of systemically delivered UC-MSC...
Rejuvenating the Niche Before the Cell: Microenvironmental Reprogramming as the Central Strategy for Pulp Regeneration in the Aged Teeth [0.03%]
衰老恒牙根管组织再生的微环境重编程策略研究
Mohammed Zayed,Byung-Hoon Jeong
Mohammed Zayed
Photobiomodulation Therapy and Wnt/β-Catenin Signaling in Periodontal Ligament Stem Cells: is there a Mechanistic Link Accelerating Orthodontic Tooth Movement? [0.03%]
光生物调制疗法和Wnt/β-catenin信号在牙周膜干细胞中的作用：是否有机制加速牙齿正畸移动？
Rashin Bahrami,Maryam Pourhajibagher,Abbas Bahador
Rashin Bahrami
Natural Killer Cell Immunotherapy After Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia Patients: Phase I Clinical Trial [0.03%]
异基因造血干细胞移植后自然杀伤细胞免疫治疗急性白血病患者的临床研究（I期）
Shiva Eskandarian,Amirhossein Izadpanah,Saye Parkhideh et al.
Shiva Eskandarian et al.
Background: Immunotherapy offers a promising approach to prevent relapse and transplant complications. Natural killer (NK) cells play a crucial role in the immune system's initial defense against infections and malignant ...
Unraveling the Multifaceted Roles of Tissue-Resident Macrophages: Focus on Bone Homeostasis and Regeneration [0.03%]
阐明组织驻留巨噬细胞的多种作用：聚焦骨骼稳态与再生
Xinyi Feng,Qifeng Wu,Yangxuanyu Yan et al.
Xinyi Feng et al.
Tissue-resident macrophages (TRMs) are essential regulators of tissue homeostasis and regeneration across multiple organs. While their roles in systems such as the liver, brain, and skin have been increasingly clarified, their functions in ...
Effects Of Oxygen Tension On iPSC Morphology And Small Extracellular Vesicle Particle Characteristics [0.03%]
氧张力对诱导多能干细胞形态和小型细胞外囊泡颗粒特性的影响
Siti Zawiah Abdul Malik,Siti A M Imran,Min Hwei Ng et al.
Siti Zawiah Abdul Malik et al.
Gasdermin A3 Drives Hair Graying via Ectopic Melanocyte Stem Cell Differentiation and Migration [0.03%]
Gasdermin A3通过异常黑素干细胞分化和迁移驱动头发变白
Haiying Guo,Xiufeng Bai,Hao Gong et al.
Haiying Guo et al.
Yumeng Lin,Yuchen He,Quan Yuan et al.
Yumeng Lin et al.
Bone repair is a complex regenerative process involving inflammatory responses, vascular remodeling, and stem cell-mediated osteogenesis, wherein the immune microenvironment plays a critical regulatory role. Neutrophils have long been recog...
DMBT1 in Adipose-Derived Stem Cell-Derived Exosomes Participates in Alleviating Ferroptosis to Promote Diabetic Wound Healing [0.03%]
来源于脂肪间充质干细胞外泌体的DMBT1通过缓解铁死亡促进糖尿病创面修复
Yan Liu,Jinnan Wang,Yujiao Cai et al.
Yan Liu et al.
Diabetic wounds represent one of the most severe complications of diabetes, and their clinical management remains challenging. This study investigated the therapeutic potential of adipose-derived stem cell-derived exosomes (ADSCs-Exo) for d...