Accessory Inner Segment-Like Structures Develop in Human Retinal Organoids [0.03%]
人视网膜类器官中类似附段结构的发展
Kristen E Ashworth,Cassandra D&#x;Amata,Brian G Ballios
Kristen E Ashworth
Purpose: A novel photoreceptor structure, called the accessory inner segment (aIS), was recently identified in human rod photoreceptors. It is described as a microtubule-based, mitochondria-rich extension of the conventio...
Exosomal Biomarkers: Paving the Way for Precision Diagnosis in Orthopedics [0.03%]
外泌体生物标志物在骨科精准诊断中的应用前景
Ramya Lakshmi Rajendran,Prakash Gangadaran,Sathish Muthu et al.
Ramya Lakshmi Rajendran et al.
Hypoplastic Left Heart Syndrome Cardiomyocytes Exhibit Intrinsic Stress Vulnerabilities and Augmented Stress Responses in vitro [0.03%]
低心腔左心室综合征心脏细胞具有内在的压力脆弱性和体外增强的压力反应
Margarida Varela,Minna Ampuja,Martin Broberg et al.
Margarida Varela et al.
Background: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect characterised by underdevelopment of left-sided cardiac structures. While genetic predisposition contributes to HLHS, the relevance of...
Circulating Biomarkers of Vascular Regeneration are not Associated with Residual Pulmonary Vascular Obstruction after Pulmonary Embolism: A Retrospective Observational Biomarker Study [0.03%]
循环血管再生生物标志物与肺栓塞后残留肺血管阻塞无关：一项回顾性观察生物标志物研究
Menfild Margotonne,Nicolas Gendron,Olivier Sanchez et al.
Menfild Margotonne et al.
Background: Residual pulmonary vascular obstruction (RPVO) persists in a substantial proportion of patients after acute pulmonary embolism (PE) despite adequate anticoagulation and is associated with long-term functional ...
Engineering and Integrating Blood Vessel Organoids: a Comprehensive Blueprint for Physiological and Disease Modeling [0.03%]
工程与整合血血管器官体：生理和疾病建模的综合蓝图
Yanlin Xu,Nuerjiamali Wubuli,Jiaoyue Zhang
Yanlin Xu
The human vascular network is a highly dynamic, complex and organ-specific microenvironment essential for organ homeostasis. Traditional 2D cell cultures fail to capture its complex intercellular interactions, tissue-specific architectures,...
Mitochondrial Regulation of Periodontal Ligament Stem Cell Fate and Function [0.03%]
线粒体调控牙周韧带干细胞的命运和功能
Zixuan Zhao,Sijia Liu,Na Liu et al.
Zixuan Zhao et al.
Periodontal ligament stem cells (PDLSCs) are regarded as among the most promising seed cells for periodontal tissue regeneration because of their strong self-renewal ability, multipotent differentiation potential, and accessibility. However...
Mesenchymal Stromal Cells in Immunometabolic Regulation: A Review of Itaconate-Mediated Mechanisms [0.03%]
间充质基质细胞在免疫代谢调控中的作用：丙酮酸脱氢酶介导的机制综述
Rosana Lopes Rodrigues Amon,Giulia Toscano Giannini,Sumara de Freitas et al.
Rosana Lopes Rodrigues Amon et al.
Immunometabolism has emerged as a central regulator of immune responses, linking cellular metabolism to inflammatory signaling and tissue homeostasis. Among tricarboxylic acid (TCA) cycle-derived metabolites, itaconate has gained recognitio...
Neural Stem Cell-Derived Extracellular Vesicles: The Next Frontier in Neurological and Neurodegenerative Diseases [0.03%]
神经干细胞源外泌体在神经系统和神经退行性疾病中的作用及机制展望
Hany E Marei,Carlo Cenciarelli
Hany E Marei
The present manuscript provides a comprehensive overview of neural stem cell (NSC)-derived extracellular vesicles (NSC-EVs( as a cell-free approach to treating central nervous system (CNS) disorders. The study noted that NSCs are regenerati...
"Stem Cell Biobanks as Indispensable Infrastructures for Advancing New Approach Methodologies (NAMs)" [0.03%]
“干细胞生物库作为推进新方法学的重要基础设施”
Mamata Mishra,Akbarsha Mohammad Abdulkader,Rinky Kapoor et al.
Mamata Mishra et al.
Javeria Umber,Uzair Ahmed,Tazeem Fatima et al.
Javeria Umber et al.
The in vitro organoid concept is a significant technical advancement that has proven to be a valuable tool in a variety of fundamental biology and therapeutic applications. This physiologically relevant 3D model enables the study of key in ...