From Ferroptotic Stress to Stemness: TNT-Mediated EMT Plasticity in Cancer Progression [0.03%]
从铁死亡应激到干细胞性：癌细胞进展中炎性小体介导的上皮间质转化可塑性
Aishani Sengupta,Priya Samanta,Jhinuk Basu et al.
Aishani Sengupta et al.
Tumor evolution is shaped by adaptive responses to metabolic and oxidative stress, rather than solely by genetic mutations. Ferroptosis is an iron-dependent mechanism of cell death driven by lipid peroxidation. This process acts both as a t...
2-Methoxyestradiol Suppresses Stemness and Epithelial-Mesenchymal Transition in Drug-Resistant Esophageal Squamous Cell Carcinoma by Targeting the Snail Signaling Pathway in Cancer Stem Cells [0.03%]
2-甲氧基雌二醇通过针对癌干细胞中Snail信号通路抑制药物抵抗性食管鳞状细胞癌的干性和上皮间充质转化现象
Jie Yan,Shuhua Han,Keqi Zhang et al.
Jie Yan et al.
Cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) are critical contributors to tumor drug resistance, which represents a major obstacle to successful cancer therapy. 2-Methoxyestradiol (2ME2) is an endogenous metabolite o...
Primordial Germ Cell Development in Teleosts: Their Origin, Fate and Role in Sex Determination [0.03%]
硬骨鱼类原始生殖细胞的发育：其起源、命运和性别决定作用
Komeil Razmi,Chris G Carter,Jawahar Patil
Komeil Razmi
In the context of sexual reproduction, primordial germ cells (PGCs) are the progenitors of life; they develop into gametes and safeguard fertility. By virtue of their diverse reproductive strategies, fishes provide appealing models to study...
Stem Cell Therapy for Traumatic Brain Injury: Translational Mechanisms, Biomarkers, and Clinical Trials [0.03%]
干细胞治疗创伤性脑损伤：转化机制、生物标志物和临床试验
William T Creel,Sukhpreet Randhawa,Richard E Hartman
William T Creel
Traumatic brain injury (TBI) is a leading cause of persistent cognitive, motor, and neuropsychiatric impairment, arising from both the initial mechanical insult and a prolonged cascade of secondary injury processes. While primary injury ref...
ANXA3 activates HIF-1α/VEGF Signaling Via the PI3K/AKT/mTOR Pathway to Promote Osteosarcoma Stem Cell-Like Phenotype [0.03%]
Annexin A3通过PI3K / AKT / mTOR途径激活HIF-1α / VEGF信号传导以促进骨肉瘤干细胞样表型
Shengtao Wang,Yan Sun,Wei Peng et al.
Shengtao Wang et al.
Background: Aberrant activation of HIF‑1α contributes to the maintenance of CSC phenotypes in various malignancies. Our previous work revealed that ANXA3 is up‑regulated in OS cells. Here, we further investigated how A...
The Influence of Fibroblast Microenvironment on the Differentiation and Maturation of Stem Cell-Derived Cardiomyocytes [0.03%]
成纤维细胞微环境对诱导多能干细胞来源心肌细胞分化和成熟的影响
Yuliang Dong,Haozhe Jiang,Fan Zhou et al.
Yuliang Dong et al.
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a promising cell source for myocardial repair. However, iPSC-CMs generated in vitro exhibit an immature phenotype resembling the fetal stage in terms of morphol...
m1A Modification: An Emerging Epitranscriptomic Regulator of Stem Cell Fate [0.03%]
m1A修饰：一种新兴的调控干细胞命运的表转录组调节因子
Ni Gan,Kang Yan,Jianbo Yang et al.
Ni Gan et al.
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Mediate Mitochondrial Delivery in Injury: Mechanistic Insights, Evidentiary Tiers, and Translational Challenges [0.03%]
间充质基质细胞来源的外泌体调节损伤中的线粒体传递：机制、证据分级及转化挑战
Tingkun Ma,Yuan He,Jincui Yang et al.
Tingkun Ma et al.
While mesenchymal stromal cell (MSC)-derived extracellular vesicles (MSC-EVs) offer a safer, cell-free alternative to stem cell transplantation, their specific role in rescuing recipient cell mitochondrial networks requires precise definiti...
Next-Generation Hepatocyte Expansion: Bridging Molecular Reprogramming with Multicellular Organoids for Clinical Translation [0.03%]
下一代肝细胞扩增：将分子重编程与多细胞类器官结合以实现临床转化
Yiyang Zhou,Min Zeng,Gongbo Fu et al.
Yiyang Zhou et al.
Orthotopic liver transplantation (OLT) remains the gold standard treatment for end-stage liver disease but is severely limited by donor scarcity and immune rejection. Consequently, bioartificial liver (BAL) systems and hepatocyte transplant...
Stem Cell and Stem Cell-Derived Extracellular Vesicles: Therapeutic Potential and Mechanistic Insights in Anti-Aging [0.03%]
干细胞和干细胞源性外泌体的抗衰老治疗潜力及机制研究进展
Jinfeng Liu,Dong Li,Shuxing Wu et al.
Jinfeng Liu et al.
Aging is driven by interconnected molecular and cellular processes (senescence, inflammation, proteostasis decline, mitochondrial dysfunction) that reduce tissue repair and organismal resilience, resulting in an increased prevalence of chro...