Human Umbilical Cord Mesenchymal Stem Cells in Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) Therapy: Mechanisms, Clinical Efficacy, and Future Perspectives [0.03%]
代谢紊乱相关性脂肪肝病(MAFLD)治疗中人脐带间充质干细胞的作用机制、临床疗效及未来前景
Hua Jiang,Hui Wang,Yankun Zhu et al.
Hua Jiang et al.
There is currently no approved drug treatment for metabolic dysfunction-related fatty liver disease (MAFLD). Umbilical cord-derived mesenchymal stem cells (UC-MSCs) show therapeutic potential, but their mechanism of action is remains incomp...
Artificial Blood and Stem Cell-Derived Oxygen Therapeutics in Oncology: Emerging Strategies for Overcoming Tumor Hypoxia [0.03%]
肿瘤低氧条件下人工血液和干细胞衍生氧气治疗在肿瘤学中的新兴策略
Kamini Shivhare,Syed Shadab Raza
Kamini Shivhare
Tumor hypoxia represents one of the primary obstacle in effective cancer therapy by conferring drug resistance to chemotherapy, radiotherapy, and immunotherapy, and facilitating tumor growth and immune escape. The use of artificial oxygen c...
Cell-Type-Specific Calibration of Mitochondrial Ubiquitination in Stem Cell Fate Decisions [0.03%]
干细胞命运决定过程中线粒体泛素化的细胞类型特异性校准
Hao-Cheng Liu,Si-Yuan Chen,Nan-Nan Yu et al.
Hao-Cheng Liu et al.
Stem cell fate decisions-whether to self-renew, differentiate, or senesce-are inextricably linked to the metabolic identity and quality-control status of mitochondria. The ubiquitin-proteasome system and selective autophagy pathways assembl...
From Gene Function to Precision Intervention: CRISPR/Cas9 and Stem Cell-Based Strategies as Emerging Disease-Modifying Approaches in PMOS [0.03%]
从基因功能到精准干预：CRISPR/Cas9和基于干细胞的策略作为PMOS中新兴的疾病修饰方法
Masuma Khatun,Karolina Lundin,Timo Tuuri et al.
Masuma Khatun et al.
Polyendocrine metabolic ovarian syndrome (PMOS) is a complex endocrine-metabolic disorder affecting up to 18% of women worldwide and remains the leading cause of anovulatory infertility. Despite extensive research, current treatments primar...
Overcoming Immunological Barriers in MSC-Derived Insulin-Producing Cells through CRISPR-Based Hypoimmunogenic Engineering and Translational Perspectives for Type 1 Diabetes [0.03%]
通过CRISPR-Based Hypoimmunogenic工程克服MSC来源的胰岛素产生细胞的免疫屏障及1型糖尿病的转化前景
Zahid Yaseen,Mothilal M
Zahid Yaseen
Mesenchymal stromal cell (MSC)-derived insulin-producing cells (IPCs) represent an emerging strategy for β-cell replacement in type 1 diabetes mellitus (T1DM) owing to their differentiation potential, intrinsic immunomodulatory properties,...
A Letter Matters: ADRB2 rs1042713 c.46A Modulates Anti-osteogenic Effect of Epinephrine in Human Mesenchymal Stem Cells [0.03%]
第46位腺苷酸等位基因多态性通过调控去甲肾上腺素对间充质干细胞成骨抑制效应的分子机制研究
Olga Krasnova,Julia Sopova,Valeriia Borodii et al.
Olga Krasnova et al.
Osteoporosis (OP) is a systemic bone disease affecting millions worldwide, characterized by long-term asymptomatic development that manifests in low-energy fractures. Due to their high stability, genetic markers represent a promising strate...
Targeted Strategies of Adipose Stem Cells for Metabolic Diseases: Mechanisms and Clinical Translation Challenges [0.03%]
针对代谢性疾病脂肪干细胞靶向策略：机制与临床转化挑战
Menghan Chen,Siqi Ding,Wanying Chen et al.
Menghan Chen et al.
Metabolic diseases, such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, and atherosclerosis, represent a growing global health burden. Adipose-derived stem cells (ADSCs) have emerged as promising therapeutic agents...
Research Progress on Biomaterial Scaffolds Carrying Stem Cells for Inflammation Regulation After Spinal Cord Injury [0.03%]
脊髓损伤后载干细胞生物材料支架的抗炎研究进展
Nanjian Xu,Xiaoyin Chai,Weihu Ma et al.
Nanjian Xu et al.
The inflammatory cascade triggered by spinal cord injury (SCI) presents a major barrier to tissue repair. This review summarizes recent advances in this field. It outlines the selection criteria for different scaffold materials and stem cel...
Dnmt3L Acetylation as a Post-Translational Switch Linking Extracellular Environment to Epigenetic Stability in Pluripotent Stem Cells [0.03%]
DNMT3L乙酰化作为多能干细胞表观遗传稳定性的一分子水平环境开关
Janitri Venkatachala Babu,Kandasamy Nagarajan ArulJothi,Ramya Lakshmi Rajendran et al.
Janitri Venkatachala Babu et al.
Targeting Gli1+ Cells for Oral Tissue Regeneration and Disease Treatment [0.03%]
靶向Gli1+细胞用于口腔组织再生和疾病治疗
Li Xiao,Mi Ai,Laidi Wu et al.
Li Xiao et al.
The Hedgehog (Hh) signaling pathway plays an essential role in tissue development and homeostasis.Glioma-associated oncogene homolog 1 (Gli1) functions as a key transcription factor in Hedgehog signaling and acts as a direct target gene wit...