Harnessing Endogenous Plasticity Rather than Reprogramming of Mature Cells Will Advance Regenerative Medicine, Cancer Treatment and Rejuvenation [0.03%]
利用内在细胞重编而非对成熟细胞去编程能推进再生医疗、癌症治疗及恢复青春的研究工作
Deepa Bhartiya,Nripen Sharma,Anish Tripathi et al.
Deepa Bhartiya et al.
The successful culture of human embryonic stem (hES) cells from inner cell mass cells of blastocyst stage 'spare' embryos in 1998, followed by induced pluripotent stem (iPS) cells in 2006, which allowed somatic cells to be reprogrammed to p...
Hair Follicle Stem Cells: Emerging Physiology and Therapeutic Applications [0.03%]
毛囊干细胞：新兴的生理学和治疗应用
Shuyuan Yang,Qun Chen,Hanluo Li et al.
Shuyuan Yang et al.
Hair follicle stem cells (HFSCs) have been studied for their role in developmental biology, hair cycling and transplantation. However, recent research reframes the hair follicle as a heterogeneous regenerative ecosystem capable of respondin...
Cell Therapy as Metabolic Rescue after Ischemic Stroke: Rewiring Bioenergetics, Redox Homeostasis, and Neurovascular Repair [0.03%]
细胞治疗在缺血性卒中后的代谢救援：重塑生物能量、氧化还原平衡及神经血管修复
Salar Bakhtiyari,Iraj Alipourfard
Salar Bakhtiyari
Ischemic stroke represents a dynamic metabolic disorder of the neurovascular unit (NVU) rather than a static vascular occlusion followed by neuronal demise. Immediate oxygen and glucose deprivation rapidly deplete ATP, disrupt the transmemb...
Nanotechnology-enabled precision targeting of lung cancer stem cells: Recent developments and therapeutic implications [0.03%]
纳米技术在肺癌干细胞精准靶向中的新进展及治疗意义
Yi Zhang,Jiaxin Fan,Yuhan Ye et al.
Yi Zhang et al.
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for more effective therapeutic strategies. Lung cancer stem cells (LCSCs) play critical roles in tumor initiation, metastasis,...
Measurable Residual Disease and the Unresolved Biology of Leukemic Stem Cells [0.03%]
可测量的残留疾病和白血病干细胞未解决的生物学问题
Deepa Bhartiya,Nitu Jha,Shruti Dutta et al.
Deepa Bhartiya et al.
Measurable residual disease (MRD) testing has transformed the management of hematologic cancers by enabling detection of residual malignant cells after therapy. Current approaches rely on qPCR and next-generation sequencing to monitor leuke...
Optimized Metabolic Conditions Reveal the Adipogenic Competence of Wharton's Jelly MSCs: Insight from Literature Review and Experimental Validation [0.03%]
优化的代谢条件揭示了沃顿胶间充质干细胞的向脂分化潜能：文献回顾与实验验证的见解
Cécile Pinault,Audrey Cras,Michel-Gabriel Cazenave et al.
Cécile Pinault et al.
Mesenchymal stromal/stem cells (MSCs) derived from distinct tissue niches exhibit marked functional heterogeneity, yet the determinants governing their adipogenic competence remain incompletely understood. Wharton's jelly MSCs (WJ-MSCs) are...
Mitochondrial Communication Networks in the Bone Microenvironment: From the Maintenance of Homeostasis to Translational Interventions for Bone Diseases [0.03%]
骨微环境中的线粒体通讯网络：从维护稳态到骨病的转化干预措施
Wentao Wang,Kun Wang,Wenjing Wang et al.
Wentao Wang et al.
Intercellular mitochondrial transfer has recently emerged as an important concept in bone biology, providing a new framework for understanding immune-metabolic cross-talk within the bone microenvironment. This microenvironment is a dynamic ...
GLP1 Mimetics and Stem Cells: An Intersection of Metabolic and Regenerative Medicine [0.03%]
GLP1 mimetics与干细胞：代谢与再生医学的交汇点
Mikhail G Kolonin
Mikhail G Kolonin
Glucagon-like peptide-1 receptor agonists (GLP1RAs) have transformed the treatment of obesity and type 2 diabetes, but their effects extend beyond metabolic regulation. Emerging evidence suggests that GLP1R signaling influences embryonic an...
Revitalizing Mesenchymal Stem Cells: Overcoming the Barriers of Diabetic Glucotoxicity in Regenerative Medicine [0.03%]
糖尿病糖毒性在再生医学中复苏间充质干细胞：克服障碍
Chengyuan Bao,Cunmin Zhou,Tongxu Zeng et al.
Chengyuan Bao et al.
Stem Cell-Derived Exosomes: A Cell-Free Frontier in Peripheral Nerve Regeneration [0.03%]
干细胞来源的外泌体在周围神经再生中的细胞因子作用
Lin Lin,Lin Yan,Yaqiong Zhu et al.
Lin Lin et al.