Tethered Antigenic Suppression Shields the Hemagglutinin Head Domain and Refocuses the Antibody Response to the Stalk Domain [0.03%]
束缚的抗原抑制作用可屏蔽红细胞凝集素头部结构域并重新聚焦抗体反应以针对茎部结构域发挥作用
Donguk Kim,Kathryn Loeffler,Yixin Hu et al.
Donguk Kim et al.
Influenza has been a global health concern for the past century. Current seasonal influenza vaccines primarily elicit an antibody response that targets the immunodominant head domain of the viral glycoprotein hemagglutinin (HA), which consi...
Transformation of Linear Alkenyl N-Alkoxy Carbamates into Cyclic Bromo Carbonates [0.03%]
线性烯丙基N-烷氧甲酰胺的衍生物转化为环状溴代碳酸酯
Shyam Sathyamoorthi,Steven P Kelley
Shyam Sathyamoorthi
We present a protocol for the facile conversion of linear alkenyl N-alkoxy carbamates into cyclic bromo carbonates. The reaction is operationally simple, uses widely available, inexpensive reagents, and requires no rigorous exclusion of air...
Photocyclization of Alkenes and Arenes: Penetrating Through Aromatic Armor with the Help of Excited State Antiaromaticity [0.03%]
烯烃和芳烃的光环化反应：激发态反芳香性协助穿越芳香“护甲”
Nikolas R Dos Santos,Judy I Wu,Igor V Alabugin
Nikolas R Dos Santos
This review focuses on photocyclization reactions involving alkenes and arenes. Photochemistry opens up synthetic opportunities difficult for thermal methods, using light as a versatile tool to convert stable ground-state molecules into the...
Ratiometric Detection of Zn2+ Using DNAzyme-Based Bioluminescence Resonance Energy Transfer Sensors [0.03%]
基于DNAzyme的生物发光共振能量转移传感器对Zn2+进行比例检测
Yuting Wu,Whitney Lewis,Jing Luen Wai et al.
Yuting Wu et al.
While fluorescent sensors have been developed for monitoring metal ions in health and diseases, they are limited by the requirement of an excitation light source that can lead to photobleaching and a high autofluorescence background. To add...
Mitu Sharma,Bhupendra Adhikari,Raymond Femi Awoyemi et al.
Mitu Sharma et al.
Arylboronic acids are commonly used in modern organic chemistry to form new C-C and C-heteroatom bonds. These activated organic synthons show reactivity with heteroatoms in a range of substrates under ambient oxidative conditions. This broa...
The Non-Anhydrous, Minimally Basic Synthesis of the Dopamine D2 Agonist [18F]MCL-524 [0.03%]
不含无机盐、极少量碱条件下合成多巴胺D2受体激动剂[18F]MCL-524的新方法研究
James A H Inkster,Anna W Sromek,Vamsidhar Akurathi et al.
James A H Inkster et al.
The dopamine D2 agonist MCL-524 is selective for the D2 receptor in the high-affinity state (D2high), and, therefore, the PET analogue, [18F]MCL-524, may facilitate the elucidation of the role of D2high in disorders such as schizophrenia. H...
hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties [0.03%]
基于配体竞争饱和和理化性质的hERG阻滞预测组合站点识别方法
Himanshu Goel,Wenbo Yu,Alexander D MacKerell Jr
Himanshu Goel
Human ether-a-go-go-related gene (hERG) potassium channel is well-known contributor to drug-induced cardiotoxicity and therefore an extremely important target when performing safety assessments of drug candidates. Ligand-based approaches in...
Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with Proteins and Amino Acid Nucleophiles [0.03%]
反应性甾醇亲电子试剂：形成机制及其与蛋白质和氨基酸亲核试剂的反应
Ned A Porter,Libin Xu,Derek A Pratt
Ned A Porter
Radical-mediated lipid oxidation and the formation of lipid hydroperoxides has been a focal point in the investigation of a number of human pathologies. Lipid peroxidation has long been linked to the inflammatory response and more recently,...