OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis [0.03%]
OCE-205在大鼠和非人灵长类动物中的药代动力学和药效学分析
Stan Bukofzer,Geoff Harris,Edward E Cable
Stan Bukofzer
Treatment for complications associated with the hemodynamic consequences of decompensated cirrhosis remains suboptimal. Terlipressin, the latest pharmacological management of hepatorenal syndrome-acute kidney injury (HRS-AKI), targets the v...
Present status with impacts and roles of miRNA on Soil Transmitted Helminthiosis control: A review [0.03%]
土壤传播蠕虫病控制中的miRNA作用及其机制研究进展
Imon Mitra,Arijit Bhattacharya,Joydeep Paul et al.
Imon Mitra et al.
Soil-Transmitted Helminthiasis (STH) is one of the most widespread Neglected Tropical Diseases (NTDs), and almost 1.5 billion of the global population is affected, mostly in the indigent, countryside sectors of tropics/subtropics. STH, comm...
Retraction notice to "Myoinositol supplementation for the prevention of gestational diabetes in at-risk patients. Systemativ review and meta-analysis" [Curr. Res. Pharmacol. Drug Discov. 4C (2023) 100140] [0.03%]
有关“肌醇补充剂对高危妊娠妇女预防妊娠糖尿病的系统评价和荟萃分析”的撤稿声明[Curr. Res. Pharm. Sci. 4C(2023)100140]
Anthéa Bertrand,Denis Gallot,Bruno Pereira et al.
Anthéa Bertrand et al.
[This retracts the article DOI: 10.1016/j.crphar.2022.100140.]. © 2023 Elsevier B.V. All rights reserved.
Retraction of Publication
Current research in pharmacology and drug discovery. 2023 Jun 1:4:100154. DOI:10.1016/j.crphar.2023.100154 2023
Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice [0.03%]
阿普菲宁通过调节单胺氧化酶A活性缓解慢性应激小鼠的抑郁样行为
Juliet N Olayinka,Oluwole B Akawa,Emmanuela K Ogbu et al.
Juliet N Olayinka et al.
Chronic stress is a risk factor for depression and is characterized by elevated levels of brain monoamine oxidase A (MAOA). Mounting evidence has shown that MAOA is a biochemical link between stress and depression. Apigenin (API), a natural...
A PAM of the α1A-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer's disease mouse models without effects on blood pressure [0.03%]
一种α1A-肾上腺素受体PAM可挽救阿尔茨海默病小鼠模型中的生物标志物、长期增强和认知缺陷，且不影响血压
Robert S Papay,Shaun R Stauffer,Dianne M Perez
Robert S Papay
α1-Adrenergic Receptors (ARs) regulate the sympathetic nervous system by the binding of norepinephrine (NE) and epinephrine (Epi) through different subtypes (α1A, α1B, α1D). α1A-AR activation is hypothesized to be memory forming and co...
The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms [0.03%]
碳硫氨酯的治疗潜力：集中于细胞和分子机制
Giuseppe Caruso,Lucia Di Pietro,Vincenzo Cardaci et al.
Giuseppe Caruso et al.
Carnosine is a naturally occurring endogenous dipeptide composed by the ligation of β-alanine and L-histidine performed particularly by tissues with an increased oxidative metabolism such as muscles and brain. In the last 50 years differen...
Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter α/β to reduce bile acids reabsorption [0.03%]
岩藻糖甘露聚糖通过抑制有机阴离子转运蛋白减少胆汁酸回吸收以缓解肝肾综合征
Xiaojuan Zhao,Ting Yang,Jiayan Zhou et al.
Xiaojuan Zhao et al.
The high levels of bile acids are a critical factor in hepatorenal syndrome. Organic solute transporter α/β (Ostα/β) participate in bile acids reabsorption in the kidney. Fucoidan has the great potential in protecting against liver and ...
H T Rakshith,S Lohita,Anvil Preem Rebello et al.
H T Rakshith et al.
The prevalence, incidence, and severity of a wide variety of diseases and ailments are significantly influenced by the significant disparities that occur between the sexes. The way that men and women react to pharmacological treatment also ...
Recent advancements of miRNAs in the treatment of bone diseases and their delivery potential [0.03%]
microRNA在骨病治疗中的最新进展及其传递潜能
Ashish Ranjan Sharma,Yeon-Hee Lee,Sang-Soo Lee
Ashish Ranjan Sharma
Advances in understanding miRNAs as endogenous posttranscriptional regulatory units have projected them as novel therapeutics for several untreatable diseases. miRNAs are endogenous non-coding small single-stranded RNA molecules (20-24 nucl...
Arindam Mitra,Suman Mukhopadhyay
Arindam Mitra
Biofilm refers to microbes that associate with each other or to a surface via self-synthesized exopolysaccharides and other surface-related structures. The presence of biofilms consisting of pathogenic microbes in the food and clinical envi...