Sildenafil prevents chronic psychosocial stress-induced working memory impairment: Role of brain-derived neurotrophic factor [0.03%]
西地那非预防慢性心理社会压力引起的-working记忆损伤：脑源性神经营养因子的作用
Tareq I Jibril,Karem H Alzoubi,Nizar M Mhaidat et al.
Tareq I Jibril et al.
Background: Psychosocial stress, a common feature in modern societies, impairs cognitive functions. It is suggested that stress hormones and elevated excitatory amino acids during stress are responsible for stress-induced...
Abelacimab: A leap forward in anticoagulation with FXI and FXIa Inhibition [0.03%]
阿贝西单抗：FXI和FXIa抑制的新型抗凝药物
Hisham A Badreldin,Nada Alsuhebany,Mohammed Alzahrani et al.
Hisham A Badreldin et al.
Direct Oral Anticoagulants (DOACs) have revolutionized the treatment of thromboembolic disorders, offering targeted, effective, and safer alternatives to traditional anticoagulants like heparins and vitamin K antagonists (VKAs). Despite the...
Analysis of survival rate and persistence predictors of baricitinib in real-world data from a large cohort of rheumatoid arthritis patients [0.03%]
大型类风湿性关节炎队列中真实世界数据中的巴瑞替尼生存率和持续预测因素的分析
Simone Parisi,Becciolini Andrea,Ditto Maria Chiara et al.
Simone Parisi et al.
Objectives: The persistence in therapy of rheumatoid arthritis drugs and particularly bDMARD is a limiting factor for their long-term use. The randomized controlled trials (RCTs) may not reflect real-world contexts due to...
Khawla Nuseir,Karem H Alzoubi,Ahmad Altarifi et al.
Khawla Nuseir et al.
Purpose: In neonatal intensive care units, applying sucrose solution for analgesia is now a routine treatment for mild procedural pain. Studies of animal and human infants provide clear evidence of benefits in the short t...
Papaverine attenuates the progression of alpha naphthylisothiocyanate induce cholestasis in rats [0.03%]
乳突紫堇碱减轻α-萘异硫氰酸酯诱导的大鼠胆汁郁积的发展进程
Doaa Adnan Atshan,Munaf Hashim Zalzala
Doaa Adnan Atshan
Cholestasis is a hepatobiliary condition that manifests as acute or chronic and results from disruptions in the bile flow, formation, or secretion processes. The Farnesoid X receptor (FXR) is a vital target for the therapy of cholestasis si...
Mujahed I Mustafa,Awad A Alzebair,Ahmed Mohammed
Mujahed I Mustafa
Recombinant antibodies have emerged as powerful tools in various fields, including therapeutics, diagnostics, and research applications. The selection of high-affinity antibodies with desired specificity is a crucial step in the development...
Suhail Ahmad Mir,Ashraf Dar,Laraibah Hamid et al.
Suhail Ahmad Mir et al.
Cancer continues to increase global morbidity and mortality rates. Despite substantial progress in the development of various chemically synthesized anti-cancer drugs, the poor prognosis of the disease still remains a big challenge. The mos...
Ananta,Swati Benerjee,Paul B Tchounwou et al.
Ananta et al.
Acute promyelocytic leukemia (APL)/blood cancer is M3 type of acute myeloid leukemia (AML) formed inside bone marrow through chromosomal translocation mutation usually between chromosome 15 & 17. It accounts around 10% cases of AML worldwid...
Kinetic conversion of BIOGF1K enriched in compound K from in vitro 3-D human tissue model [0.03%]
基于体外人体三维组织模型的富集化合物K的BIOGF1K的动力学转换研究
Woo-Hyun Kim,Won-Jo Choi,Jeong-Eun Kim et al.
Woo-Hyun Kim et al.
The purposes of current study were to investigate the effect of ginsenosides from BIOGF1K enriched in compound K (CK) and compound Y (CY) on the skin barrier function, the deposition in in vitro 3-D human tissue model (EpiDermFT™ Full Thic...
Exequiel O J Porta,Patrick G Steel
Exequiel O J Porta
Activity-based protein profiling (ABPP) is a chemoproteomic technology that employs small chemical probes to directly interrogate protein function within complex proteomes. Since its initial application almost 25 years ago, ABPP has proven ...