Ferroptosis induces nucleolar stress as revealed by live-cell imaging using thioflavin T [0.03%]
应用硫黄素T活细胞成像技术揭示铁死亡可引起核仁应激
Yoko Hirata,Hiroshi Takemori,Kyoji Furuta et al.
Yoko Hirata et al.
Nucleolar stress induced by stressors like hypoxia, UV irradiation, and heat shock downregulates ribosomal RNA transcription, thereby impairing protein synthesis capacity and potentially contributing to cell senescence and various human dis...
The novel inhaled dual PDE3 and PDE4 inhibitor ensifentrine for the treatment of COPD: A systematic review and meta-analysis protocol on trough FEV1 and exacerbation according to PRISMA statement [0.03%]
一种用于治疗慢性阻塞性肺病(COPD)的新型吸入性PDE3和PDE4双效抑制剂ensifentrine：以PRISMA声明为基础的稳态FEV1和急性加重期系统评价和meta分析方案
Luigino Calzetta,Mario Cazzola,Shima Gholamalishahi et al.
Luigino Calzetta et al.
The investigation of ensifentrine, an inhaled dual phosphodiesterase (PDE)3 and PDE4 inhibitor, for chronic obstructive pulmonary disease (COPD) maintenance therapy presents a significant clinical interest. Despite promising results from re...
Molecular mechanisms and therapeutic potential of natural flavonoids in diabetic nephropathy: Modulation of intracellular developmental signaling pathways [0.03%]
天然黄酮类化合物在糖尿病肾病分子机制及治疗潜能：调节细胞内发育信号通路
Mahaboob Khan Sulaiman
Mahaboob Khan Sulaiman
Recognized as a common microvascular complication of diabetes mellitus (DM), diabetic nephropathy (DN) is the principal cause of chronic end-stage renal disease (ESRD). Patients with diabetes have an approximately 25% risk of developing pro...
The potential of miRNA-based approaches in glioblastoma: An update in current advances and future perspectives [0.03%]
胶质母细胞瘤中基于miRNA的方法的潜力：当前进展和未来展望的更新
Edgar G Ordóñez-Rubiano,Nicolás Rincón-Arias,Sebastian Espinosa et al.
Edgar G Ordóñez-Rubiano et al.
Glioblastoma (GBM) is the most common malignant central nervous system tumor. The emerging field of epigenetics stands out as particularly promising. Notably, the discovery of micro RNAs (miRNAs) has paved the way for advancements in diagno...
The polyphenolic compound punicalagin protects skin fibroblasts from UVA radiation oxidative damage [0.03%]
茋类化合物punicalagin保护皮肤成纤维细胞免受UVA辐射氧化损伤
Giada Bianchetti,Patrizia Bottoni,Giuseppe Tringali et al.
Giada Bianchetti et al.
Polyphenols are a class of natural compounds that act as antioxidants, neutralising harmful free radicals that would damage cells and increase the risk of diseases such as cancer, diabetes and heart disease. They also reduce inflammation, w...
Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet [0.03%]
利拉鲁肽通过改善高脂饮食诱导的小鼠腹型肥胖模型的脂肪重塑和线粒体动态发挥抗肥胖作用
Vanessa Touceda,Florencia Fontana Estevez,Leonardo Cacciagiú et al.
Vanessa Touceda et al.
Central obesity is characterized by visceral adipose tissue (VAT) expansion, considered one of the main risk factors for metabolic complications. In recent years, new drugs have been studied for obesity treatment. Liraglutide (LGT), a GLP-1...
Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids [0.03%]
应激对胰岛β细胞功能的影响及其饮食类黄酮的潜在治疗作用研究
Kingsley C Mbara,Marthe C D Fotsing,Derek T Ndinteh et al.
Kingsley C Mbara et al.
Diabetes mellitus (DM) is a global health burden that is characterized by the loss or dysfunction of pancreatic β-cells. In pancreatic β-cells, endoplasmic reticulum (ER) stress is a fact of life that contributes to β-cell loss or dysfun...
Energy substrate supplementation increases ATP levels and is protective to PD neurons [0.03%]
能量底物补充增加PD神经元的ATP水平并发挥对其保护作用
Andrey Y Vinokurov,Marina Y Pogonyalova,Larisa Andreeva et al.
Andrey Y Vinokurov et al.
Alteration of mitochondrial metabolism by various mutations or toxins leads to various neurological conditions. Age-related changes in energy metabolism could also play the role of a trigger for neurodegenerative disorders. Nonetheless, it ...
Stem cell therapy as a promising approach for ischemic stroke treatment [0.03%]
干细胞治疗在缺血性脑卒中治疗中的应用前景
Sahar Yaqubi,Mohammad Karimian
Sahar Yaqubi
Ischemia as the most common type of stroke is the main cause of death and disability in the world. However, there are few therapeutic approaches to treat ischemic stroke. The common approach to the treatment of ischemia includes surgery-cum...
Mefloquine-curcumin combinations improve host mitochondrial respiration and decrease mitotoxic effects of mefloquine in Plasmodium berghei-infected mice [0.03%]
甲氟喹-姜黄素联合用药改善受疟原虫感染的小鼠宿主线粒体呼吸并降低甲氟喹的线粒体毒性作用
John Oludele Olanlokun,Oshireku Wisdom Abiodun,Adekunle Theophilus Adegbuyi et al.
John Oludele Olanlokun et al.
Plasmodium infection is a health challenge. Although, antiplasmodial drugs kill the parasites, information on the effects of infection and drugs on the expression of some genes is limited. Malaria was induced in two different studies using ...