Targeting c-Met in breast cancer: From mechanisms of chemoresistance to novel therapeutic strategies [0.03%]
乳腺癌中的c-Met靶向治疗：从化疗耐药机制到新型治疗策略
Emeka Eze Joshua Iweala,Doris Nnenna Amuji,Abimbola Mary Oluwajembola et al.
Emeka Eze Joshua Iweala et al.
Breast cancer presents a significant challenge due to its heterogeneity and propensity for developing chemoresistance, particularly in the triple-negative subtype. c-Mesenchymal epithelial transition factor (c-Met), a receptor tyrosine kina...
Alpha-lipoic acid: A promising pharmacotherapy seen through the lens of kidney diseases [0.03%]
α-硫辛酸：透过肾脏疾病视角观察的颇具前景的药物治疗方案
George J Dugbartey,Karl K Alornyo,Christabel O Dapaa-Addo et al.
George J Dugbartey et al.
Kidney diseases have rapidly increased in prevalence over the past few decades, and have now become a major global public health concern. This has put economic burden on the public healthcare system and causing significant morbidity and mor...
Exacerbation of atherosclerosis, hyperlipidemia and inflammation by MK886, an inhibitor of leukotriene biosynthesis, in obese and diabetic mice [0.03%]
一种白三烯生物合成抑制剂MK886加重肥胖和糖尿病小鼠动脉粥样硬化、高脂血症和炎症反应
Katherine Keever,Bardia Askari
Katherine Keever
Leukotrienes are potent mediators of the inflammatory response and 5-lipoxygenase, the enzyme responsible for their synthesis, is dependent on its interaction with 5-lipoxygenase activating protein for optimum catalysis. Previous studies ha...
Hepatoprotective effect of Nobiletin against 5-fluorouracil induce hepatotoxicity [0.03%]
芸香素对5-氟尿嘧啶致肝损伤的保护作用研究
Safa A Yahya,Nada N Al-Shawi
Safa A Yahya
5-florouracil is a widely used anticancer/anti-metabolite drug used to treat solid tumor like colon cancer, head and neck, rectum, stomach, pancreas and breast cancer; but, it can cause hepatotoxicity by induction of apoptosis through activ...
Farnoosh Saadati,Amir Modarresi Chahardehi,Negar Jamshidi et al.
Farnoosh Saadati et al.
Coumarin, a naturally occurring compound found in various plants, has a rich history of use in traditional medicine. Recent research has highlighted its anti-inflammatory properties, positioning it as a promising candidate for treating infl...
Quercetin prevents rats from type 1 diabetic liver damage by inhibiting TGF-ꞵ/apelin gene expression [0.03%]
芸香苷通过抑制TGF-β/aplin基因表达防止1型糖尿病肝损伤
Gholampour Firouzeh,Abbasi Susan,Karimi Zeinab
Gholampour Firouzeh
Background: Hyperglycemia-induced oxidative stress is a significant contributor to diabetic complications, including hepatopathy. The current survey aimed to evaluate the ameliorative effect of quercetin (Q) on liver func...
Characterization of 2-((4-(chloromethyl)benzoyl)oxy)benzoate acid for analgesic tablet dosage form formulation [0.03%]
苦味酸氯甲基苄酯的止痛片剂处方特性研究
Wuryanto Hadinugroho,Yudy Tjahjono,Kuncoro Foe et al.
Wuryanto Hadinugroho et al.
The 2-((4-(chloromethyl)benzoyl)oxy)benzoic acid (4CH2Cl) is a potential analgesic compound derived from salicylic acid and 4-chloromethyl benzoyl chloride. Characterization required 4CH2Cl for the formulation of tablet dosage forms. This s...
Zyad Al-Frejat,Nafiza Martini,Alia Esper et al.
Zyad Al-Frejat et al.
GERD is a very familiar diagnosis among health care providers due to its massive spread, and its symptoms can affect the quality of life for a respectable slice of its patients. Therefore, what can only be described as a logical consequence...
Scaling approaches for the prediction of human clearance of LNA-i-mir-221: A retrospective validation [0.03%]
用于预测LNA-i-mir-221人类清除率的缩放方法：回顾性验证
Massimiliano Fonsi,Jacques Fulbert,Pierre-Andre Billat et al.
Massimiliano Fonsi et al.
LNA-i-miR-221 is a novel microRNA(miRNA)-221 inhibitor designed for the treatment of human malignancies. It has recently undergone phase 1 clinical trial (P1CT) and early pharmacokinetics (PKs) data in cancer patients are now available. We ...
Samer Younes
Samer Younes
The part of sexuality in pharmacology research was not acknowledged, and it was not thought-out to be a determinant that could impact strength and disease. For decades research has mainly contained male, women and animals, leading to a lack...