Tissue distribution pharmacokinetics of intrathecal U1 adaptor oligonucleotide in mice [0.03%]
寡核苷酸药物腰椎给药后的小鼠组织分布药代动力学研究
Medha Satti,Kavita Prasad,Yash Patel et al.
Medha Satti et al.
U1 Adaptor is a novel gene-silencing technology, offering an innovative approach to target genes in the CNS for the treatment of diseases. Intrathecal delivery is a medically viable route of administration of CNS-bound nucleic acid drugs; t...
Real-world clinical utility (effectiveness) of omalizumab as add-on therapy in patient with difficult-to-treat severe allergic asthma [0.03%]
奥马珠单抗作为难治性重度过敏性哮喘附加疗法的现实世界临床应用价值（疗效）
Rowshne Jahan,Ziaul Huq
Rowshne Jahan
Background: Severe allergic asthma (SAA) requires high-dose inhaled corticosteroids and additional medications. It poses a substantial health and financial burden. Omalizumab, an antibody that targets IgE, has improved sy...
Probing into the chemopreventive properties of synthetic 1,3,6-tri-O-galloyl-α-D-glucose (α-TGG) against glioblastoma and triple-negative breast cancer-derived cell models [0.03%]
探究合成茋三棓酸酯(α-TGG)对胶质母细胞瘤及三阴性乳腺癌细胞模型化学预防作用机制
Carolane Veilleux,Jihane Khalifa,Alain Zgheib et al.
Carolane Veilleux et al.
Inflammation plays a significant role in cancer progression. Chemopreventive strategies against cellular response to pro-inflammatory cues may therefore contribute to inhibit the acquisition of an invasive phenotype. 1,3,6-Tri-O-Galloyl-β-...
Anti-inflammatory potential of quercetin: From chemistry and mechanistic insight to nanoformulations [0.03%]
槲皮素的抗炎潜力：从化学和机制见解到纳米制剂
Diwakar Aggarwal,Mayank Chaudhary,Sachin Kumar Mandotra et al.
Diwakar Aggarwal et al.
Flavonoids are hydroxylated polyphenols that are abundantly produced by plants as secondary metabolites. These flavonoids hold vast therapeutic potential as they possess numerous medicinal benefits encompassing anti-inflammatory, anti-oxida...
ABCC1 and ABCC10 as predictive biomarkers of docetaxel treatment response in prostate cancer [0.03%]
ABCC1和ABCC10作为预测多西他赛治疗前列腺癌反应的生物标志物
Nandi Ngesi,Beynon Abrahams,Aubrey Shoko et al.
Nandi Ngesi et al.
Prostate cancer (PCa) is a leading global health burden, with a particularly high prevalence in South Africa. Despite therapeutic advancements, chemoresistance remains a major challenge, limiting the efficacy of docetaxel and contributing t...
Corrigendum to "Metabolic and clinical effect of alpha-lipoic acid administration in schizophrenic subjects stabilized with atypical antipsychotics: A 12-week, open-label, uncontrolled study" [Curr. Res. Pharmacol. Drug Discov. 3 (2022) 100116] [0.03%]
《“α-硫辛酸对稳定服用非典型抗精神病药物的 schizophrenic 主体的代谢和临床影响：一项为期12周、开放标签、无对照的研究”[Curr. Res. Pharmacol. Drug Discov. 3 (2022) 100116] 的勘误》
注释：由于schizophrenic主体翻译可能不太恰当，我保留了其英文形式。在中文语境中，“schizophrenic”通常指患有精神分裂症的个体，可以视上下文具体要求进一步调整为“患有精神分裂症的受试者”。
Fiammetta Iannuzzo,Gianpaolo Antonio Basile,Domenica Campolo et al.
Fiammetta Iannuzzo et al.
[This corrects the article DOI: 10.1016/j.crphar.2022.100116.]. © 2025 Published by Elsevier B.V.
Mechanisms of nebivolol-mediated effects on bFGF-induced vascular smooth muscle cell proliferation and migration [0.03%]
奈比洛尔对bFGF诱导的血管平滑肌细胞增殖和迁移的影响机制
Elaina Seemann,Trevor Beeler,Mohammed Alfarra et al.
Elaina Seemann et al.
Background: Nebivolol is a β-adrenergic receptor antagonist that has intrinsic activity on β3-adrenergic receptors (β3-ARs). Previous studies suggest that nebivolol inhibits bFGF-induced vascular smooth muscle cell (VS...
The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib [0.03%]
SPHK1/S1P/S1PR3信号传导路径的抑制可减少EGFR活化并增加非小细胞肺癌对吉非替尼的敏感度
Jing Zhang,Zequn Wang,Xihua Wei et al.
Jing Zhang et al.
Non-small-cell lung cancer (NSCLC) represents a predominant histological subtype of lung cancer, characterized by high incidence and mortality rates. Despite significant advancements in therapeutic strategies and a deeper understanding of t...
Metformin's impact on asprosin and FBN1 expression: Potential mechanisms beyond insulin sensitivity in type 2 diabetes in rats [0.03%]
二甲双胍对asprousin和FBN1表达的影响：大鼠2型糖尿病中改善胰岛素抵抗的潜在机制
Ali Dashtkar,Mansour Karajibani,Mohsen Saravani et al.
Ali Dashtkar et al.
Background: Asprosin, a novel adipokine released under fasting conditions, may play a significant role in the pathophysiology of type 2 diabetes mellitus (T2DM). The objective of this study is to investigate the effects o...
Unveiling the chemotherapeutic potential of two platinum(IV) complexes in skin cancer: in vitro and in vivo Insights [0.03%]
两种铂(IV)复合物在皮肤癌化疗中的潜力：体内外研究见解
Amjad Slika,Christina Haydar,Joelle Bou Chacra et al.
Amjad Slika et al.
The present study investigates the chemotherapeutic potential of two platinum (IV) complexes, P-PENT and P-HEX, against skin cancer in vitro and in vivo. Both complexes exhibited potent cytotoxicity against HaCaT-II-4 cells with IC50 values...