Can the application of graphene oxide contribute to the fight against COVID-19? Antiviral activity, diagnosis and prevention [0.03%]
氧化石墨烯在抗击COVID-19中能发挥什么作用？抗病毒活性、诊断和预防
Asmaa Rhazouani,Khalid Aziz,Halima Gamrani et al.
Asmaa Rhazouani et al.
COVID-19 is an infectious disease that affects the respiratory system and is caused by the novel coronavirus SARS-CoV-2. It was first reported in Wuhan, China, on December 31, 2019, and has affected the entire world. This pandemic has cause...
Devavrat Tripathi,Megha Sodani,Pramod Kumar Gupta et al.
Devavrat Tripathi et al.
The global spread of SARS-CoV-2 has necessitated the development of novel, safe and effective therapeutic agents against this virus to stop the pandemic, however the development of novel antivirals may take years, hence, the best alternativ...
Recent progress in the development of potential drugs against SARS-CoV-2 [0.03%]
对抗SARS-CoV-2潜在药物研发的近期进展
Jianmin Chen,Fayaz Ali,Imran Khan et al.
Jianmin Chen et al.
SARS-CoV-2, a newly emerged and highly pathogenic coronavirus, is identified as the causal agent of Coronavirus Disease (2019) (COVID-19) in the late December 2019, in China. The virus has rapidly spread nationwide and spilled over to the o...
Physiopathology and prospectives for therapeutic treatment of pulmonary fibrotic state in COVID-19 patients [0.03%]
COVID-19患者肺纤维化状态的生理病理及治疗前景
Antonio Vitiello,Francesco Ferrara
Antonio Vitiello
The COVID-19 global pandemic has caused about 4,30 Mln deaths. Recently the first vaccines have been licensed, representing the most powerful weapon available to stop the pandemic. The COVID-19 viral infection in the most severe cases can c...
Teriflunomide: A possible effective drug for the comprehensive treatment of COVID-19 [0.03%]
特立氟胺：一种可能对COVID-19综合治疗有效的药物
Amgad M Rabie
Amgad M Rabie
The coronavirus disease 2019 (COVID-19) pandemic has undoubtedly become a global crisis. Consequently, discovery and identification of new or known potential drug candidates to solve the health problems caused by the severe acute respirator...
Can NLRP3 inhibitors improve on dexamethasone for the treatment of COVID-19? [0.03%]
NLRP3抑制剂能否在COVID-19治疗上改善地塞米松的疗效？
Alexander Hooftman,Luke A J O&#x;Neill
Alexander Hooftman
Dexamethasone, a corticosteroid, has been approved for use in the treatment of severe COVID-19, which is characterised by hyperinflammation and associated lung damage. However, dexamethasone shows no clinical benefit in the treatment of les...
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside [0.03%]
瑞德西韦及其母核核苷的抗SARS-CoV-2活性和细胞内代谢比较研究
Sijia Tao,Keivan Zandi,Leda Bassit et al.
Sijia Tao et al.
Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment of moderate to severe COVID-19. It has been suggested to use GS-441524 instead of remdesivir in the clinic and in new inhalation formulatio...
Artificial intelligence-driven drug repurposing and structural biology for SARS-CoV-2 [0.03%]
用于SARS-CoV-2的人工智能驱动的药物重定位和结构生物学研究
Kartikay Prasad,Vijay Kumar
Kartikay Prasad
It has been said that COVID-19 is a generational challenge in many ways. But, at the same time, it becomes a catalyst for collective action, innovation, and discovery. Realizing the full potential of artificial intelligence (AI) for structu...
Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/ 3CLpro: molecular docking and simulation studies of three pertinent medicinal plant natural components [0.03%]
SARS-CoV-2 (COVID 19)蛋白酶PLpro和Mpro/3CLpro的潜在抑制剂：三种相关药用植物天然成分的分子对接与模拟研究
Devvret Verma,Debasis Mitra,Manish Paul et al.
Devvret Verma et al.
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - coronavirus disease 2019 (COVID-19) has raised a severe global public health issue and creates a pandemic situation. The present work aims to study the molec...
Pathophysiology and possible treatments for olfactory-gustatory disorders in patients affected by COVID-19 [0.03%]
COVID-19患者嗅味障碍的病理生理及可能治疗方向
Francisca Idalina Neta,Amélia Carolina Lopes Fernandes,Adson José Martins Vale et al.
Francisca Idalina Neta et al.
SARS-CoV-2 infects host cells mainly through the interaction between the virus's Spike protein and the viral receptors namely Angiotensin-Converting Enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Both are highly expressed in...