Prenatal and early postnatal food restrictions cause changes in brain oxidative status and orexigenic/anorexigenic hormones in the offspring of rats: prevention by quercetin and kaempferol [0.03%]
母体孕期和子代早期营养限制可引起大鼠后代脑内氧化状态以及摄食/抑食性激素的变化：芦丁和山奈酚对其具有预防作用
Kenneth Kelechi Anachuna,Goodies Emuesiri Moke,Cordilia Iyare et al.
Kenneth Kelechi Anachuna et al.
Brain oxidative signaling pathways have been identified as important targets for alleviating food deprivation-induced changes in metabolic gate-ways. Previous studies have shown that prenatal and early postnatal malnutrition alters leptin a...
Narges Abdoli,Issa Sadeghian,Khadijeh Mousavi et al.
Narges Abdoli et al.
Cirrhosis-induced renal injury or cholemic nephropathy (CN) is a serious clinical complication with poor prognosis. CN could finally lead to renal failure and the need for organ transplantation. Unfortunately, there is no specific pharmacol...
Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain [0.03%]
长效稳定靶向递送并评估家猪及大鼠脑内封装细胞分泌GDNF的效果研究
Lars U Wahlberg,Dwaine F Emerich,Jeffrey H Kordower et al.
Lars U Wahlberg et al.
Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 cells to del...
Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction [0.03%]
硫醇还原剂的口服给药可通过减轻胆道梗阻大鼠模型中的肠道屏障功能障碍而减少细菌脂多糖的移位
Mohammad Mehdi Ommati,Omid Farshad,Hossein Niknahad et al.
Mohammad Mehdi Ommati et al.
It has been well documented that cirrhosis is associated with the intestinal injury. Intestinal injury in cirrhosis could lead to bacterial lipopolysaccharide (LPS) translocation to the systemic circulation. It has been found that high plas...
Joshua Moody,Chalen Yang,Jessica Sedinkin et al.
Joshua Moody et al.
Atherosclerosis involves interactions between inflammation system and dyslipidemia. MCPIP1 (Monocyte Chemotactic Protein induced Protein-1) is induced by proinflammatory molecules and serves as a negative feedback loop in regulating inflamm...
Poppy O Smith,Peiqin Jin,Khondaker Miraz Rahman
Poppy O Smith
Repurposing regulatory agency approved drugs and investigational compounds with known safety profiles can significantly fast track the drug development timeline over de novo drug discovery, with lower investment requirements and improved at...
Potential value of pharmacological agents acting on toll-like receptor (TLR) 7 and/or TLR8 in COVID-19 [0.03%]
作用于Toll样受体（TLR）7和/或TLR8的药物在COVID-19中的潜在价值
Amani E Khalifa,Asser I Ghoneim
Amani E Khalifa
The COVID-19 pandemic is an ongoing global pandemic of coronavirus disease 2019 as an atypical type of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many potential pharmacotherapies are currently be...
Potential inhibitors of SARS-CoV-2 (COVID 19) spike protein of the delta and delta plus variant: In silico studies of medicinal plants of North-East India [0.03%]
东北印度药用植物中潜在的SARS-CoV-2（COVID 19）刺突蛋白(delta和delta plus变异体)抑制剂：计算机研究
Peter Solo,M Arockia Doss
Peter Solo
Phytochemicals of 38 Medicinal plants of North-East India, with anti-viral, anti-oxidant or anti-bacterial properties were screened for properties of drug likeness. 231 phytochemicals were screened with LIPINSKI rule of five to obtain 131 c...
The development of biologics to target SARS-CoV2: Treatment potential of antibodies in patient groups with poor immune response [0.03%]
针对SARS-CoV2的生物制剂的研发：抗体在免疫反应较差的患者群体中的治疗潜力
William Migo,Marko Boskovic,Robert Likic
William Migo
Development of novel antibodies to combat the novel SARS-CoV-2 virus is ongoing. Importantly, particular subgroups are more prone to severe disease, namely patients with poor immune responses. This includes cancer patients with solid and ha...
An updated review on potential therapeutic drug candidates, vaccines and an insight on patents filed for COVID-19 [0.03%]
针对COVID-19潜在的治疗药物和疫苗候选者最新评论及对已申请专利的一些见解
G S N Koteswara Rao,Buduru Gowthami,N Raghavendra Naveen et al.
G S N Koteswara Rao et al.
The outbreak of COVID-19 was recognized in December 2019 in China and as of October5th, the pandemic was swept through 216 countries and infected around 34,824,108 individuals, thus posing an unprecedented threat to world's health and econo...