Joanna Woo,Cynthia Koziol-White,Reynold Panettieri Jr et al.
Joanna Woo et al.
Obesity is emerging as a global public health epidemic. The co-morbidities associated with obesity significantly contribute to reduced quality of life, mortality, and global healthcare burden. Compared to other asthma comorbidities, obesity...
Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents [0.03%]
包衣技术在时辰治疗给药系统中的应用：近期文献和专利回顾
Buduru Gowthami,S V Gopala Krishna,D Subba Rao
Buduru Gowthami
In general, extended release systems have the ability to maintain the drug concentration with in therapeutic range for prolonged period of time, but this may not be the primary requisite for circadian rhythm diseases like asthma, hypertensi...
Reversal of TGF-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma by sorafenib, a VEGFR-2 and Raf kinase inhibitor [0.03%]
索拉非尼逆转转化生长因子-β诱导的肝细胞癌上皮间质转换现象
Siddharth J Modi,Anshuly Tiwari,Vithal M Kulkarni
Siddharth J Modi
The epithelial-mesenchymal transition (EMT) is considered an essential process for cancer development and metastasis. Sorafenib, a RAF kinase and VEGFR-2 inhibitor, exhibits efficacy against advanced hepatocellular carcinoma (HCC), renal ca...
Dina W Yakout,Nitheyaa Shree,Angela M Mabb
Dina W Yakout
Activity-regulated cytoskeleton-associated protein (Arc) is a brain-enriched immediate early gene that regulates important mechanisms implicated in learning and memory. Arc levels are controlled through a balance of induction and degradatio...
Perspective insights of repurposing the pleiotropic efficacy of statins in neurodegenerative disorders: An expository appraisal [0.03%]
他汀类药物在神经退行性疾病中多效性的再利用见解：一种解释性评价
Aditi Bhat,Harshita Dalvi,Harsha Jain et al.
Aditi Bhat et al.
Neurodegenerative disorders which affects a larger population pose a great clinical challenge. These disorders impact the quality of life of an individual by damaging the neurons, which are the unit cells of the brain. Clinicians are faced ...
Beclomethasone dipropionate and sodium cromoglycate protect against airway hyperresponsiveness in a human ex vivo model of cow's milk aspiration [0.03%]
贝氯米松和色甘酸钠通过体外实验模型保护牛奶误吸引起的气道高反应性
Beatrice Ludovica Ritondo,Paola Rogliani,Francesco Facciolo et al.
Beatrice Ludovica Ritondo et al.
Background: Recurrent cow's milk (CM) aspiration is often associated with gastroesophageal reflux in infants and toddlers and it seems to be implicated in the etiology of different inflammatory lung disorders. This study ...
Paola Rogliani,Beatrice Ludovica Ritondo,Bartolomeo Zerillo et al.
Paola Rogliani et al.
Chronic obstructive respiratory disorders uncontrolled by monotherapy should be given combinations of drugs that act by distinct mechanisms of action. The rationale for combining different classes of drugs should be to elicit a synergistic ...
Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases [0.03%]
红豆蔻素在慢性疾病预防和治疗中的新兴作用及其作为多靶标药物的潜力
Uzini Devi Daimary,Dey Parama,Varsha Rana et al.
Uzini Devi Daimary et al.
Although chronic diseases are often caused by the perturbations in multiple cellular components involved in different biological processes, most of the approved therapeutics target a single gene/protein/pathway which makes them not as effic...
Niccolò Riccardi,Diana Canetti,Paola Rodari et al.
Niccolò Riccardi et al.
Even if major improvements in therapeutic regimens and treatment outcomes have been progressively achieved, tuberculosis (TB) remains the leading cause of death from a single infectious microorganism. To improve TB treatment success as well...
Excellence paves the way with current research in pharmacology and drug discovery [0.03%]
药理学和药物发现领域的最新研究铺就卓越之路
Luigino Calzetta,Cynthia Koziol-White
Luigino Calzetta