Dina W Yakout,Nitheyaa Shree,Angela M Mabb
Dina W Yakout
Activity-regulated cytoskeleton-associated protein (Arc) is a brain-enriched immediate early gene that regulates important mechanisms implicated in learning and memory. Arc levels are controlled through a balance of induction and degradatio...
Perspective insights of repurposing the pleiotropic efficacy of statins in neurodegenerative disorders: An expository appraisal [0.03%]
他汀类药物在神经退行性疾病中多效性的再利用见解：一种解释性评价
Aditi Bhat,Harshita Dalvi,Harsha Jain et al.
Aditi Bhat et al.
Neurodegenerative disorders which affects a larger population pose a great clinical challenge. These disorders impact the quality of life of an individual by damaging the neurons, which are the unit cells of the brain. Clinicians are faced ...
Beclomethasone dipropionate and sodium cromoglycate protect against airway hyperresponsiveness in a human ex vivo model of cow's milk aspiration [0.03%]
贝氯米松和色甘酸钠通过体外实验模型保护牛奶误吸引起的气道高反应性
Beatrice Ludovica Ritondo,Paola Rogliani,Francesco Facciolo et al.
Beatrice Ludovica Ritondo et al.
Background: Recurrent cow's milk (CM) aspiration is often associated with gastroesophageal reflux in infants and toddlers and it seems to be implicated in the etiology of different inflammatory lung disorders. This study ...
Paola Rogliani,Beatrice Ludovica Ritondo,Bartolomeo Zerillo et al.
Paola Rogliani et al.
Chronic obstructive respiratory disorders uncontrolled by monotherapy should be given combinations of drugs that act by distinct mechanisms of action. The rationale for combining different classes of drugs should be to elicit a synergistic ...
Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases [0.03%]
红豆蔻素在慢性疾病预防和治疗中的新兴作用及其作为多靶标药物的潜力
Uzini Devi Daimary,Dey Parama,Varsha Rana et al.
Uzini Devi Daimary et al.
Although chronic diseases are often caused by the perturbations in multiple cellular components involved in different biological processes, most of the approved therapeutics target a single gene/protein/pathway which makes them not as effic...
Niccolò Riccardi,Diana Canetti,Paola Rodari et al.
Niccolò Riccardi et al.
Even if major improvements in therapeutic regimens and treatment outcomes have been progressively achieved, tuberculosis (TB) remains the leading cause of death from a single infectious microorganism. To improve TB treatment success as well...
Excellence paves the way with current research in pharmacology and drug discovery [0.03%]
药理学和药物发现领域的最新研究铺就卓越之路
Luigino Calzetta,Cynthia Koziol-White
Luigino Calzetta
Prenatal and early postnatal food restrictions cause changes in brain oxidative status and orexigenic/anorexigenic hormones in the offspring of rats: prevention by quercetin and kaempferol [0.03%]
母体孕期和子代早期营养限制可引起大鼠后代脑内氧化状态以及摄食/抑食性激素的变化：芦丁和山奈酚对其具有预防作用
Kenneth Kelechi Anachuna,Goodies Emuesiri Moke,Cordilia Iyare et al.
Kenneth Kelechi Anachuna et al.
Brain oxidative signaling pathways have been identified as important targets for alleviating food deprivation-induced changes in metabolic gate-ways. Previous studies have shown that prenatal and early postnatal malnutrition alters leptin a...
Narges Abdoli,Issa Sadeghian,Khadijeh Mousavi et al.
Narges Abdoli et al.
Cirrhosis-induced renal injury or cholemic nephropathy (CN) is a serious clinical complication with poor prognosis. CN could finally lead to renal failure and the need for organ transplantation. Unfortunately, there is no specific pharmacol...
Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain [0.03%]
长效稳定靶向递送并评估家猪及大鼠脑内封装细胞分泌GDNF的效果研究
Lars U Wahlberg,Dwaine F Emerich,Jeffrey H Kordower et al.
Lars U Wahlberg et al.
Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 cells to del...